Scientific Program

Keynote Talks

Abstract

Cell hydration determines its functional activity via “folding-unfolding” mechanism of intracellular macro-molecules and cell surface-dependent changes of protein molecules’ activity, having enzymes, receptors and ionic channels forming properties. Therefore, the metabolically controlled cell hydration is of vital importance for living cells. The facts that intracellular osmotic pressure exceeds the extracellular one and that the membrane permeability for water is much higher than for ions, the osmotically driven water influx is balanced by metabolically generated water efflux from the cell. Our data have shown that net water influx and efflux through membrane activate and inactivate inward going ionic current in membrane. Therefore, this makes the ability of metabolic compensation of osmotically driven water influx as a marker for estimation of beneficial and harmful effects of any physical and chemical factors on cells and organisms. Among the number of metabolic mechanisms involved in regulation of cell hydration, Na+/K+-pump has a central role, which is due to both generations of Na+ gradients on membrane, serving as energy sources for a number of secondary ionic transporters in membrane, and water efflux from the cells. Our recent study has shown that the dysfunction of Na+/K+-ATPase a3 isoform-dependent signaling system controlling cell hydration is the common primary mechanism for cell pathology. In may talk the suggestion on the use of a3 isoform-dependent signaling system controlling cell hydration as a novel therapeutic target for treatment of different diseases will be discussed.

Biography

Prof. Sinerik Ayrapetyan has completed his PhD in Cell Biophysics in the Institute of Physiology of Ukraine Academy of Sciences, Kiev. He is the head of Research Council and the coordinator of UNESCO Chair in Life Sciences at Life Sciences International Postgraduate Educational Center, Yerevan, Armenia. His current research interest is “Intracellular Signaling System in Norm and Pathology”. He has published 7 international books and 115 papers. He is an Editor in Chief of the journal “Bioavailability and Bioequivalence”, and a member of editorial board of the journals: "Electromagnetic Biology and Medicine", "Journal of International Dental and Medical Research", “ISRN Biophysics”, “Advances in Life Sciences", “Applied Pharmacy”, “European Journal of Biophysics”, “Biochimica et Biophysica Acta” etc. He is a member of International Coordination Council of WHO and number of professional international societies.

Speaker
Sinerik Ayrapetyan UNESCO Chair-Life Sciences International Postgraduate Educational Center
Armenia

Abstract

Peptide therapeutics have become very attractive drugs due to their high bioactivity, high specificity and low toxicity. However, these are difficult-to-administer drugs, since they show a short half-life, a low stability profile and a very low permeability through cell membranes. Due to their physicochemical characteristics, peptides are usually administered through the parenteral route, often several times daily. Injectable sustained-release peptide formulations based on biodegradable microparticles or implants have been very successful to enhance patient adherence and convenience, and increase safety and efficacy [1]. They are likely to remain a significant and important part of the new peptide products coming to the market. However, the tremendous developments in alternative non-invasive routes of delivery are likely to result in more and more peptides being delivered by the transdermal, nasal, inhalation and oral routes [2] in the next years. The main purpose of this talk will be to analyze and compare the various oral peptide delivery technologies progressing in the clinic, discussing the pros and cons of these technologies in regards to stability, bioavailability, excipient safety profile, impact on costs of goods and manufacturability [3]. A special emphasis will be put on future challenges anticipated for filing and launching new oral peptide products with systemic therapeutic effects in the next years.

Biography

Joel Richard is currently Senior Vice President, Peptides in IPSEN (France). He is globally leading all the CMC developmentactivities of both injectable peptide products and oral small molecules, including APIs and drug products, with major franchises in Oncology, Endocrinology and Neurology. Dr Richard has more than 25 years of experience in chemistry and biopharmaceutical RandD, including several global senior positions in various Biotech and Pharma companies, such as:Vice President, Drug Product Development in Ipsen (France) (2008-2011), Director, Pharmaceutical Development in Serono andMerck Serono (Italy, Germany) (2005-2008), Vice President Research, and Europe RandD Director at Ethypharm (France) (2001- 2004), COO at Mainelab (France), a drug delivery company he co-founded, which was specialized in developing solvent-free processes for protein delivery systems (1999-2001). Since 1996, Dr Richard has focused his research activity on new formulationtechnologies and drug delivery systems (such as microspheres, nanoparticles, nanocapsules, chemically-modified proteins,supercritical fluid technology . . .), especially for injectable protein and peptide formulations. Dr Richard has published 64 peer- reviewed scientific papers, 7 book chapters and 2 review editorials in various fields (colloids and interfaces, drug delivery, supercritical fluids, protein formulations, nanoparticles, sustained-release formulations . . .). He is the author of more than 100 international communications and 51 patent families.

Speaker
Joël Richard IPSEN
France

Abstract

Dr. Chandran has spent better part of the last 40 years contemplating the role of scientists in improving the quality of human life. During his scientific and business adventures, he realized that while his chosen field is intellectually satisfying, life beyond science could be more enthralling if science can be put to work to combat life’s idiosyncrasies. He will talk about a) significant scientific breakthroughs he achieved in understanding cardiovascular diseases and their treatment; b) how one of his drugs, a Propofol derivative would have prevented the premature death of famous pop/rock star Michael Jackson; c) serendipitous discoveries leading to the separation of racemic mixtures of wide chemical and therapeutic categories of drugs and the implications; d) first time development of a narcotic strength pain killer without any addiction potential; e) how to zero in on few right molecules for a given treatment quickly using guerilla innovation and a multi-disciplinary approach to drug discovery. From his life experiences he will demonstrate that harder you work, luckier you get. Why all talented scientists must experiment with business ideas to appreciate the validation of good scientific discoveries in the marketplace will be explored. Dr. Chandran will provide examples from his own life and present his case through a surprisingly unusual format.

Biography

Dr. Chandran is a distinguished alumnus of the University of Florida, USA, and spent more than 30 years in business, research and development. He has obtained numerous worldwide patents encompassing more than 9000 drugs (NCEs). He is a practitioner of research, interested in zeroing in on handful of molecules that will ultimately pass the regulatory hurdles to become best in class drugs in a short period of time. He had successfully built and sold profitable drug manufacturing and marketing businesses in the USA. He is also a commercial instrument rated pilot, enjoys flying both airplanes and helicopters as a hobby.

Speaker
V. Ravi Chandran Life Enhancing Technologies, LLC. Allen, TX 75002, USA

Abstract

Controlling the interaction of drug delivery systems (DDS) with biological tissues is critical for the success of therapies. Specifically in cancer, due to the high density of the tumors, tissue penetration of DDS is critical and may be challenging. We show that polymer nanoparticles can be used efficiently to deliver small molecule drugs into cancer cells and tissues. Our recent work show the effect of mechanical cues of drug vehicle on their interactions with tumor cells and tissue-like 3D structures ex-vivo. Using polymer micelles we compared flexible "Wet Polymer Micelles" (WPM) to semi-solid "Solidified Polymer Micelles" (SPMs) for their physiochemical properties and their interactions with cancer cells. The composition of the polymer micelles, both flexible and rigid remained the same while the only difference was their mechanical properties. For that we have performed detailed characterization of SPM compared to WPM, including examinations of particle size, stability, drug release kinetics and cell transcytosis, in melanoma cells. Cell uptake measurements show enhanced abilities of SPMs to penetrate cells and tissues. A simple physical model is presented that well agrees with the experiments and provides insight about the role of particle rigidity in the engulfment mechanism. We conclude that particle rigidity can enhances cellular uptake and tissue penetration and that mechanical properties of DDS be used as a selective principle for drug uptake. We also introduced SPMs as a promising and effective, highly permeable DDS. Our findings can be important in future rational design of DDS for particle adjustment to specific tissues and pathology, and for personalized Nanomedicine.

Biography

Dr. Benny received her Ph.D in Biotechnology Engineering from the Technion in Israel, and joined as a postdoctoral fellow the lab of the late Dr. Judah Folkman, in Boston Children’s Hospital and Harvard Medical School. Currently Dr. Ofra Benny headsthe research laboratory at the Institute for Drug Research, School of Pharmacy, and Faculty of Medicine in the Hebrew University in Israel. Her laboratory focuses on cancer research and drug development based on synthetic and natural compounds. Dr. Benny was awarded with the ERC-starting grant and holds many other grants and awards including the Marie Curie CIG and M-Era-Net.

Speaker
Ofra Benny The Hebrew University
Israel

Abstract

EllaOne® (micronized-UPA30mg) is marketed for emergency contraception; its mechanism of action is reported to be the inhibition/delay of ovulation (EMA-EPAR WC500023670,p.8). We acknowledged its anti-ovulatory effectiveness in the first fertile day, but this effectiveness is placebo-like in the most fertile pre-ovulatory days, in which most fertilizations occur (ReprodSci2014;21(6):678-85). Besides, the dose of UPA sufficient to affect endometrial receptivity is far lower than that used to try ovulation delay. The EMA-Assessment Report EMEA/261787/2009 states (p.8) that “UPA prevents progesterone from occupying its receptor, thus (omissis) the proteins necessary to begin and maintain pregnancy are not synthesized”. That means that UPA has both anti-implantation and abortifacient properties. Besides, UPA’sexperimental effectiveness (p.8) and off-label use as abortifacient are acknowledged (p.45-46). TheEMA-Assessment Report EMA/73099/2015 evidences that patients treated with ellaOne® every 7th or 5th day for two months ovulate in 91.7% and 72.7% cases, respectively, and the cervical mucus was permeable to sperms (pp.6-8). A recent paper (MolCell Endocrinol2017;447:1-11) confirms that in women taking ellaOne® in the pre-ovulatory days ovulationconsistently takes places, but the changes observed the expression of1183 genes in their luteal endometrial samples evidence a“non-receptive phenotype”. Our review shows that ellaOne®allows ovulation In the most fertile days, but, in case of fertilization, the embryo will find a non-receptive endometrium. The EMA-CHMP is aware of this, but repeats that ellaOne® delays ovulation (http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/001027/WC500023670.pdf)(pp.8,24) (June2017 EPAR-update). The information delivered to health operators and women through the Package leafletis evidently incorrect.  

Biography

Assistant Professor of Gynecology at the University of Padua Teacher of “Family Planning” in the post-graduate School of Gynecology and Obstetrics. Teacher of Obstetrics and Gynecology in the Degree Courses of Nursing and of Midwifery. Author of several papers in reputed journals and of the book “Da Vita a Vita”, 3rdEdition,SEU,Rome,2013 Chairman of SIPRe (Società Italiana Procreazione Responsabile), http://www.sipre.eu/the-association/ . SIPRe is a Scientific Association promoting conscious and responsible procreative choices, enabling people to preventfertilization. It promotes the divulgation of information concerning reproductive physiology, prerequisite to free choices, and that concerning the birth-control methods and their mechanism of action.

Speaker
Bruno Mozzanega University of Padua
Italy

Sessions:

Abstract

More than 80 years ago O. Warburg pointed out the loss of oxidative capacity of mitochondria by the cancerous cell. In these cells the glycolytic metabolism shifts relative to oxidative phosphorylation even under aerobic conditions (Warburg 1956). Later it is established that cancerous tissue is overhydrated and contains more than 90% of water (Kuricuta et al. 1973). This fact served as a background for developing the method of nuclear magnetic resonance (NMR) for early determination of tumor (Damadian 1971). However, the nature of metabolic mechanism controlling cell hydration and its functional relationship with Warburg phenomenon has not been elucidated yet. My talk will be dedicated to presenting experimental data on the role of α3 isoform-dependent signaling system controlling cell hydration in generation of cell overhydration and Warburg phenomenon. It is known that α3 isoforms of Na+/K+-ATPase, which are absent in non-excitable cells of healthy animals, are highly expressed in cancerous cells. On the basis of this, the expression of these isoforms is considered as one of the early hallmarks for carcinogenesis (Shibuya 2010, Weidemann 2012). However, by our recent work it has been shown that all 3 isoforms are present both in tumor and non-excitable tissues of mice carrying sarcoma-180. Therefore, it was hypothesized by us that the dysfunction of Na+/K+-ATPase α3 isoform-dependent intracellular signaling system controlling cell hydration could serve as a primary mechanism for carcinogenesis. In order to check this hypothesis we have studied the dose-dependent ouabain effect on intracellular cyclic nucleotides (cAMP and cGMP), glycolysis rate (lactate concentration in blood and lactate dehydrogenase activity), membrane permeability for protons, intracellular pH and Ca2+ in both healthy and mice carrying sarcoma-180 by means of electrophysiological, isotope, immunoassay and microscopic methods. The obtained data have brought us to conclusion that in normal tissue the metabolic control of cell hydration is realized by cGMP-dependent activation of Na+/Ca2+ exchange in forward mode, while in all tissues of mice carrying sarcoma-180 the decontrolling of cell hydration (overhydration) is due to activation of cAMP-dependent Na+/Ca2+ exchange in reverse mode, which activates glycolyse activity, increases intracellular Ca2+, decreases pH resulting in the increase of CO2 solubility and decrease of O2 solubility responsible for generation of Warburg phenomenon. Based on this, it is suggested that decontrolling of cell hydration (overhydration) could serve as a novel biomarker for early detection of carcinogenesis.

Biography

Prof. Sinerik Ayrapetyan has received his PhD in Cell Biophysics in the Institute of Physiology of Ukraine Academy of Sciences, Kiev. Currently, he is the coordinator of UNESCO Chair at Life Sciences International Postgraduate Educational Center, Yerevan, Armenia. His research has included the study of metabolic regulation of cell function in norm and pathology. He is serving as a Chief Editor for the Journal of “Bioequivalence and Bioavailability”, and an editorial member of several reputed journals like “Electromagnetic Biology and Medicine”, “ISRN Biophysics”, “European Journal of Biophysics”, “Advances in Life Sciences", “Applied Pharmacy”, “BBA General Subjects”, “International Dental and Medical Research", “International Journal of Basic and Applied Sciences”, “Insights of Medical Sciences”, “Chronicles of Pharmaceutical Science Journal”, “Clinical Investigations”, “Global Drugs and Therapeutics” etc. Prof. Sinerik Ayrapetyan is a member of a number of international societies, such as International Society of Invertebrate Neurobiology (ISIN), International Society for neurochemistry (ISN), European Society for Neurochemistry (ESN), International Brain Research Organization (IBRO), International Union of Pure and Applied Biophysics (IUPAB), Bioelectromagnetics Society (BEMS), WHO International Advisory Committee on Electromagnetobiology and the president of “All Armenian Research Council”. He has authored 7 international books and 115 research articles.

Speaker
Sinerik Ayrapetyan UNESCO Chair-Life Sciences International Postgraduate Educational Center
Armenia

Abstract

Inhaled medication is the cornerstone of the pharmacological treatment for patients with asthma and chronic obstructive pulmonary disease (COPD). Pulmonary drug delivery is relatively complex because the respiratory tract has evolved defence mechanisms to keep inhaled drug particles out of the lungs and to remove or inactivate them once deposited. In addition to these mechanical, chemical and immunological barriers, pulmonary drug delivery is adversely affected by the behavioural barriers of poor adherence and poor inhaler technique. Several inhaler devices exist, and each device has specific characteristics to achieve the optimal inhalation of drugs. The correct use of inhaler devices is not granted and patients may incur in mistakes when using pressurized metered-dose inhalers (pMDIs) or dry-powder inhaler (DPIs).Montelukast, a cysteinyl leukotriene type 1 receptor antagonist, exhibits secondary anti-inflammatory properties when used at higher concentrations. Low-molecular-weight heparin (LMWH) evokes pronounced anti-inflammatory effects by interrupting leukocyte adhesion and migration. Inhalable particles containing montelukast plus LMWH release both drugs in a sustained fashion and protect the lungs against allergen-induced inflammation.The incorrect use of inhaler devices can lead to a poorly controlled disease status. Unfortunately, guidelines provide limited guidance regarding the choice of devices. Each type of device has its own pro and cons. The age, cognitive status, visual acuity, manual dexterity, manual strength and ability to coordinate the inhaler actuation with inhalation may be as important as the disease severity in determining the correct approach to delivery of respiratory medication. The administration of effective therapies via a device that is simple to use and accepted by patients may help to improve treatment outcomes in patients with COPD. Owing to the advantages offered by the pulmonary route, the challenges that the route poses are worth addressing, and if successfully addressed, the pulmonary route offers huge opportunities fulfilling clinical needs.

Biography

Dr Mohammed Shamssain has Ph.D from Loughborough University, United Kingdom. He has been working at various universities world-wide and has significant number of published articles and international conference presentations. He is the founder of Sunderland ISAAC Centre (the International Study of Asthma and Allergies in Childhood). He is an Associate Professor at Ajman University, UAE.

Speaker
Mohammed Shamssain Ajman University,br> UAE

Abstract

Objective: Obesity is one of important challenging problem in developed and developing countries .In this work we designed a low fat base cream with active ingredient licorice extract. Experimental: Standardized 2% Glycyrrhetinic acid in low fat cream base was applied on the upper side of thighs of 20 young healthy girls volunteers students for one month two times daily.On another thigh the placebo of the same formulation cream base was used for comparison. The circumference of the thighs and thickness of the skin fat were measured each week at the three points by mean of ruler and a caliper respectivelyand the records were averaged . To check the level of the blood cortisol and pressure, they were measured weekly to detect the probable side effect of the cream containingcortisol like effect Glycyrrhetinicacid . Results: after two weeks ,the entire thighs for tested cream showed significant reduction in the fat while the placebo never reduced the fat any more. How ever after four weeks the circumference showed significant reduction compare to the placebo. Conclusion: this cream would reduce the fat topically, in reasonable period of time and potentially effective in weight losing for long time particularly for abdomen, and for body thinness on selective area only for beauty with no side effects.

Biography

He has completed his PhD from department of pharmacy,victoria university of Manchester,UK . He is professor of industrial pharmacy as a lecturer and researcher in basic and applied topic of faculty of pharmacy, Mashhad university of Medical Sciences ,Mashhad ,IR IRAN, and meanwhile the director of some projects and advisor in Iran industries and Pharm D and PhD students. He has published more than 15 papers in reputed and local journals and has been serving as an editorial board member of some Iranian journal.

Speaker
Hossein M Orafai Mashhad university of Medical Sciences
Iran

Abstract

Within the field of pharmacologically active biological macromolecules the area of stable polyethers seems rather new and attractive. A new series of linear and regular caffeic acid-derived polyether, namely poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene] or poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDPGA) was isolated and identified in the water-soluble, high molecular weight fractions obtained from Symphytum asperum, S.caucasicum, S.officinale, S.grandiflorum and Anchusa italica (Boraginaceae). According to data of 13C, 1H NMR, 1D NOE, 2D 1H/13C HSQC and 2D DOSY experiments the polyoxyethylene chain is the backbone of the polymer molecule. The 3,4-Dihydroxyphenyl and carboxyl groups are regular substituents at two carbon atoms in the chain. The repeating unit of this polymer is 3-(3,4-dihydroxyphenyl)glyceric acid residue. Most of the carboxylic groups of PDPGA from A. italica and S.grandiflorum unlike the polymer of S.asperum, S.caucasicum and S.officinale are methylated. PDPGA is endowed with intriguing pharmacological properties as anticomplementary, antioxidant, anti-inflammatory, burn and wound healing effect. The synthesis of racemic monomer of PDPGA 2,3-dihydroxy-3-(3,4-dihydroxyphenyl)propionic acid (DDPPA) was carried out via Sharpless asymmetric dihydroxylation of trans-caffeic acid derivatives using a potassium osmate catalyst. PDPGA and DDPPA exerted anti-cancer efficacy in vitro and in vivo against human prostate cancer (PCA) cells via targeting androgen receptor, cell cycle arrest and apoptosis without any toxicity, together with a strong decrease in prostate specific antigen level in plasma. However, our results showed that anticancer efficacy of PDPGA is more effective compared to its synthetic monomer. Overall, this study identifies PDPGA as a potent agent against PCA without any toxicity, and supports its clinical application.

Biography

Vakhtang Barbakadze has completed his Ph.D. and D.Sci. in 1978 and 1999 from Institute of Organic Chemistry, Moscow, Russia and Institute of Biochemistry and Biotechnology, Tbilisi, Georgia, respectively. He is the head of department of plant biopolymers and chemical modification of natural compounds at the Tbilisi State Medical University I.Kutateladze Institute of Pharmacochemistry. 1996 and 2002 he has been a visiting scientist at Utrecht University (faculty of pharmacy), The Netherlands, by University Scholarship and The Netherlands organization for scientific research (NWO) Scholarship Scientific Program, respectively. He has published more than 86 papers in reputed journals.

Speaker
Vakhtang Barbakadze Tbilisi State Medical University
Georgia

Abstract

The strategy of price liberalisation and privatisation had been implemented in Sudan over the last decade, and has had a positive result on government deficit. The investment law approved recently has good statements and rules on the above strategy in particular to pharmacy regulations. Under the pressure of the new privatisation policy, the government introduced radical changes in the pharmacy regulations. To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this study. Also, it highlights the current drug supply system in the public sector, which is currently responsibility of the Central Medical Supplies Public Corporation (CMS). In Sudan, the researchers did not identify any rigorous evaluations or quantitative studies about the impact of drug regulations on the quality of medicines and how to protect public health against counterfeit or low quality medicines, although it is practically possible. However, the regulations must be continually evaluated to ensure the public health is protected against by marketing high quality medicines rather than commercial interests, and the drug companies are held accountable for their conduct.

Biography

Abdeen Mustafa Omer (BSc, MSc, PhD) is an Associate Researcher at Occupational Health Administration, Ministry of Health and Social Welfare, Khartoum, Sudan. He has been listed in the book WHO’S WHO in the World 2005, 2006, 2007 and 2010. He has published over 300 papers in peer-reviewed journals, 200 review articles, 7 books and 150 chapters in books.

Speaker
Abdeen Omer Occupational Health Administration
Sudan

Abstract

The development of antibiotic resistance in pathogenic microorganism is a global health concern due to the emergence of multidrug resistant organism (MDRO). It is essential to synthesise novel antimicrobial agents to deal with increased number of multidrug resistance organisms (MDRO) and limited antimicrobial agent. Literature survey showed that quinazolin-4(3H)-one possess varied biological activities and 2nd and 3rd positions are the target for substitution with other moieties. On the other hand, isatinand sulphanilamide pharmacophore also exhibits wide range of pharmacological activities especially significant antibacterial activity though competitive inhibition of dihydropteroatesynthetase enzyme. Hence, it was thought worthwhile to study the effects of these pharmacophoric moieties in one molecule with the base of quinazolin-4(3H)-one nucleus for better the antibacterial activity. A series of mannich bases, 2-(substituted phenyl)-3-[1-(substituted aminomethyl)-2-oxoindolin-3-ylideneamino] quinazolin-4-(3H)-one derivatives and 2-(4’-substitutedphenyl)-3-[(N-2-oxoindolin-3-ylidene)-4”-sulphonamidophenyl]-quinazolin-(3H)-onewas synthesised from the intermediate schiff bases which is prepared by reacting 2-(substituted phenyl)-4H-benzo[d][1,3]-oxazin-4-one with hydrazine hydrate and the required benzoxazinone derivate has been prepared by reacting anthranilic acid with substituted benzoyl chloride. All the synthesised compounds structures were characterised by using H1 Nuclear Magnetic Resonance Spectroscopy. The intermediate schiff base and final mannich base compounds were evaluated for their antibacterial activity against Staphylococcus aureus, Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa at a concentration of 50 µg/mL and 100 µg/mL by agar well diffusion method using Norfloxacin (50 µg/mL) as standard drug. From the study, it has been observed that the sulphanilamide substituted derivatives did not showed any inhibition against all the organism whereas amino substituted shciff and mannich base showed significant degree of inhibition. Finally, it has been concluded that mannich base derivatives of amino substitution at 3rd position in quinazolinone nucleus exhibited a higher degree of inhibition and also superior in its antibacterial activity against gram positive bacteria S. aureus and B. cereus.

Biography

Dr. Gopal Natesan is Professor of Medicinal Chemistry and Deputy Dean (Research & Innovation) at MAHSA University, Kuala Lumpur and also Fellow of Higher Education Academy (FHEA) United Kingdom. He has completed his Doctoral degree (PhD) in Pharmaceutical Chemistry from JamiaHamdard, New Delhi, India in 2000 His research focuses on the synthesis of newer small chemical entities, quinazolinones heterocyclic pharmacophore and their preliminary screening in both in-vivo and in-vitro models mainly focusing on pain & inflammation and also for newer microbial agents. He has published >40 articles in indexed journals and presented >80 papers in conferences and received number of honors including “Edward Kennedy Memorial Award” in 2017 by Malaysian Medical Association, Malaysia and BioGenesis Health Cluster, India and “Young Scientist Award” in 2013 by International Society of Nature & Health Care Inc, USA and University of Colombo & University of Kelaniya, Sri Lanka. He was invited speaker at international scientific meetings and conferences and serves as reviewer for several scientific international journals and also as Editorial/Advisory board of various journals.

Speaker
Gopal Natesan MAHSA University
Malaysia

Abstract

Venlafaxine is a serotonin nor-epinephrine reuptake inhibitor used in the management of anxiety disorders, hot flushes and attention defects. Venlafaxine has poor bioavailability and short half-life, which suggests multiple frequent administrationand is considereda rational for the development of extended release formulation of venlafaxine.Development of sustained release formulation of highly water-soluble drugs, as venlafaxine HCl, is considered a challenge to the pharmaceutical technologist. Low molecular weight chitosan and beeswax is a very useful combination in food technology and this work investigated the possible use of this combination in sustaining the release of venlafaxineHCl.Low molecular weight chitosan was prepared from high molecular weight chitosan by acid depolymerization. Low molecular weight chitosan and beeswax were mixed, at different ratios, and subjected to cross-linking reactions using sodium tripolyphosphate. Venlafaxine HCl tabletswere then preparedby direct compression and characterised. In vitro release was performed using USP dissolution apparatus II at pH 6.8 and 37 ˚C. Increasing beeswax content resulted in increase in tablet thickness and hardnessand decrease in friability, disintegration and drug release. All tablets had acceptable compressibility. Tablets containing beeswax ≥70%were acceptable in terms of hardness and friability. Tablets containing beeswax ≤50% disintegrated within 30 minutes while those containing beeswax≥70% did not disintegrate throughout the study. Tablet containing 70% beeswax showed 85% drug release at 5 hours. Tablets containing ≥90% beeswax were floating during the time of experiment.

Biography

Shereen M. Assaf is currently an associate professor of Pharmaceutical Sciences, and previously a chairperson of the Department of Pharmaceutical Technology and Clinical Pharmacy and assistant dean of the Faculty of Pharmacy at Jordan University of Science and Technology - Jordan. She has a BSc in Pharmacy from Yarmouk University (Jordan) and MSc in Pharmaceutical Analysis and PhD in Pharmaceutical Sciences from Strathclyde University (Glasgow-UK). Dr. Assaf research interest is in the field of drug delivery and pharmaceutical technology. She has several publications in her field in peer-reviewed journals. She is involved in research and educational activities. She had several funded research projects; she supervised more than 20 research projects for graduate students (MSc and PhD), mostly in pharmaceutical technology and in chemistry, and is currently supervising another four projects for MSc students. Dr. Assaf is also involved in community services and is an active member in different local committees.

Speaker
Shereen M. Assaf Jordan University of Science and Technology
Jordan

Abstract

Sulfonamide derivatives are well known for their proven medicinal uses in treatment of various diseases like hypertension, inflammatory bowel disease, diabetes etc. In the current study we synthesized the variety of new sulfonamide derivatives and their copper complexes, all the synthesized materials were structurally characterized using sophisticated techniques like spectroscopy and single crystal X-rays diffraction. The synthesized compounds were used to target DNA and some protein. Prior to the biological applications, In DNA targeting studies, results anticipate the transfer of metal (Copper) in between the base pairs. The probing of metal transfer has been detected by UV-visible spectroscopy, electrochemistry and hydrodynamic studies. Further the protection of DNA from reactive oxygen has been observed.

Biography

Professor Dr. Muhammad Danish is a famous name in the field of synthetic chemistry at University of Gujrat, Gujrat, Pakistan. He earned his PhD under split program (DAAD) between Germany and Pakistan. He has two post-doctoral studies on his credit: one from Quaid-e-Azam University, Islamabad, Pakistan and second from The University of Sydney, Australia. His main domain of research is based on antimicrobials, anticancer drugs, nanomaterials and catalysis. As PI he is running two National projects funded by Higher Education Commission of Pakistan and has completed different projects as Co-PI. Since long, he has been working on the synthesis of metallic/organometallic carboxylates and platinum based anticancer compounds. He has numerous publications in the journals of international repute.

Speaker
Muhammad Danish University of Gujrat
Pakistan

Abstract

Pharmacovigilance refers to all scientific and data gathering activities relating to the detection, assessment, and understanding of adverse events. These activities are undertaken with the goal of identifying adverse eventsand understanding, their nature, frequency, and potential risk factors. The aim of this study to evaluate the educational needs (knowledge gap) of health professionals in Yaoundé, Cameroon towards adverse drug reactions reporting. The study design was a cross sectional study conducted from November to April 2014, in 3 hospitals in Yaoundé, Cameroon, in 13 community pharmacies. A pre-tested self- administered questionnaire was used to assess knowledge, attitudes and practices of participants. The data were analyzed using SPSS Version 18.0 and Microsoft Excel 2007 software. A total of 330 health professionals were enrolled in the study. One hundred and eighty-eight participants with 50 physicians (26.6%), 14 pharmacists (7.4%), 2 dentists (1.1%), 112 nurses (59.6%) and 10 midwives (5.3%) completed the questionnaire. 78 respondents out of 180 knew about the existence of a National Pharmacovigilance Centre. 77 nurses and 6 midwives were aware of the adverse drug reactions reporting system. The knowledge score of 147 (782 %) health professionals in our sample was poor and 45 health professionals (23.9%) who had a very low level of knowledge. Respondents recognized almost unanimously (94.7%) that adverse drug reactions reporting were necessary. Similarly, 171 practitioners (91 %) believed that adverse drug reaction reporting was obligatory. The knowledge, attitudes and practices of health professional towards adverse drug reactions reporting were poor in our study population.

Biography

Prof FOKUNANG obtained his PhD in 1995 in Phytopathology (option pesticide chemistry and toxicology). He has taught and did post doctoral research in Nigeria and the Athlone Institute of Technology IRELAND, In 2003 he obtained an MSc in Biotechnology,at the University of Reading, UKworked forPFIZER UK as a genetic and genomic toxicologist, and in 2006,hereturned to his country Cameroon. He belongs to many international bodies, and has won many international awards. He is currently the Director of Students’ Affairs in the University of Bamenda, Cameroon. He has published over 100 peer reviewed publications, two books and over 10 book chapters.

Speaker
Charles Fokunang University of Yaounde 1
Cameroon

Abstract

Preformulation is the connection between drug discovery and drug delivery and consists of all studies enacted on a new drug substance in order to produce useful information for subsequent formulation of a stable and biopharmaceutically suitable drug product. The lungs have the largest surface area in the human body (~100 m2of the gaseous exchange surface of the alveoli) and the airways is the route of administration of medicines, mainly but not limited topulmonary diseases like Asthma, COPD and Cystic Fibrosis.Feedback to drug discovery includes the recommendedpKa and salt form suitable for lung delivery.Solid-state characterization is crucial for dry powder inhalation compoundswhich need to be micronized and formulated into a pressurized metered dose inhaler (pMDI) or dry powder inhaler (DPI), an energy-intensive process which generates amorphous contentthat affects stability. Good stability is more important for nebulizerswhich require a solution formulation. Biomolecules as medicines can be delivered by inhalation and preformulation studies address their physical and chemical stability. Most of the drug product stability surprises are due to excipients, in particular the impurities in excipients. The elemental impurities for inhalationhave stricter limits than any other routes of administration. Of great importance are the buffers and the buffer selection needs to address the lung characteristics. Citrate and phosphate buffers are not suitable for systems that are highly Ca-dependent. TheUSP perspective on dissolution testing for aerosolsis that there are no immediate plans for aerosol dissolution methods to be added to the Expert Committee.

Biography

Andrei Blasko, Ph.D., FRSC, is a Senior Fellow and member of the Senior Leadership Team at Novartis Pharmaceuticals Corp., working inInhalation Technical Development. Previously Dr. Blasko was Director of Analytical Method Development and co-lead a Drug Discovery & CMC Development program at Pain Therapeutics, Inc.,where he managed projects in drug discovery, structural biology, and analytical method development up to NDA submission. Other companies he worked with include Celera (inflammation/oncology), Pfizer/Pharmacia/Sugen (oncology) and Roche Bioscience (neurobiology), after finishing postdoctoral work at the University of California Santa Barbara.Dr. Blasko has 30 years of experience in physical-organic and bioorganic chemistry with diverse background in drug discovery, CMC development, screening, lead optimization, and clinical candidate selection. His expertise is in analytical, preformulation, formulation, and chemical development. Dr. Blasko is Editor-in Chief for the Journal of Applied Pharmacy, a Fellow of the Royal Society of Chemistry (FRSC) and a member of the American Chemical Society (ACS), American Association of Pharmaceutical Scientists (AAPS), and International Pharmaceutical Federation (FIP).

Speaker
Andrei Blasko Novartis Pharma
USA

Abstract

Ritonavir, a BCS class II drug, used in the treatment of HIV/AIDS. The drug has shorter biological half-life (t½) of 3-5 hours, thus requires multiple/frequent dosing, and found to be an ideal candidate for controlled release formulation. In the present investigation an attempt has been made to formulate controlled release tablets of ritonavir using HPMC as release retarding material by direct compression method. The excipients employed in the formulation did not alter the physicochemical properties of the drug as confirmed by the FTIR/DSC techniques. The tablets showed good mechanical properties in terms of hardness and friability. The release of the drug from the tablets was modulated by employing varying concentrations of polymer. Mathematical analysis of drug from the tablets exhibited non-fickian diffusion obeying zero order kinetics. In vivo pharmacokinetic study of the developed controlled release tablets of ritonavir exhibited prolonged Tmax, t½ and enhanced oral bioavailability.

Biography

Dr.D.Nagasamy Venkatesh has completed his Ph.D from The Tamil Nadu Dr.MGR Medical University, Chennai, Tamil Nadu in 2011 under the Faculty of Pharmacy. Presently, He is working as Assistant Professor at JSS College of Pharmacy, Ooty. Tamil Nadu. He has published more than 45 papers in reputed journals and has been serving as an editorial board member of peer reviewed international and national journal.

Speaker
D.Nagasamy Venkatesh JSS College of Pharmacy
India

Abstract

Cyperusesculentus (tiger nut) starch is a potential source of direct-compression excipient for use in tableting but has not been commercially explored. The aim of this study was to modify and characterize the starch isolated from C. esculentus tubers and investigate its incorporation as filler/binder/disintegrant in metronidazole tablet formulation. Starch was isolated from the tubers by milling, defatting and steeping in sodium metabisulphite solution and modified via enzyme hydrolysis (ECS). Physicochemical and functional characteristics of ECS were evaluated in relation to the native starch (NCS) and microcrystalline cellulose (MCC). Tablets were formulated by direct compression and evaluated by mechanical and compaction properties. The results showed that ECS starch samples gave the best flow properties (ECS>MCC>NCS). Tablets formulated with ECS showed acceptable mechanical and compaction properties and gave the fastest onset of plastic deformation as evidenced by its low mean yield pressure, Py (62.79 MN/m2) and inverse measure of plastic deformation, Pk values (3.344). ECS tablet batches also gave a higher compressibility index (0.539) in comparison to MCC (0.461).Hence, enzymatic hydrolysis of C. esculentus starch produced a good directly compressible filler/binder that may provide a viable alternative to MCC for use in direct compression.

Biography

Ogbonna Okorie is a Nigerian and a Professor of Pharmaceutics and Pharmaceutical Technology in the University of PortHarcourt Nigeria. He earned his PhD from University of Nigeria in 2005, a place where he was a lecturer till 2007 when he rose to the rank of a senior lecturer. He has over 50 published journal articles. He has researched so much in Pharmaceutical raw materials … Sourcing, characterization and standardization for pharmaceutical excipients. Currently his research interest is in Nanotechnology. He has widely travelled and has visited Japan, China, USA, Israel, Cameroon, Monrovia, etc for academic related pursuits and paper presentations. He is a member of many organizations some of which include: RSC, GA, ASP, PSN, etc. Ogbonna is happily married to Ngozi and has five loving children.

Speaker
Ogbonna Okorie University of Port-Harcourt
Nigeria

Abstract

The hepatitis C virus is an essential agent to hepatitis infection and identified human proteins EIF2AK1, NFKBIA, IKBKB, MAPK14, ARAF and TRAF3 are vital in the life cycle of this virus and also an important target for the study of anti-viral drugs. The enzymes were identified by using KEGG database and network analysis through Cytoscape software. A novel and very promising strategy for viral drug discovery consists in blocking the multiple functional interactions with EIF2AK1, NFKBIA, IKBKB, MAPK14, ARAF and TRAF3 enzymes. In the present study, a series of novel quinazoline structures were designed and these compounds were taken along with marketed available drug Cidofovir for insilico modeling. Some of the designed quinazoline analogues exhibited significant scoring similar to that of the standard drug, thus gaining further imminent into the structure activity relationship studies as well as synthetic approach.

Biography

Panner Selvam is working as a Research Faculty in International Research Center, Kalasalingam University, Krishnankoil, Tamilnadu. He received his PhD degree in 2013 from Acharya Nagarjuna University, Guntur, India and he earned Young Faculty Award 2014 from EET CRS presents Academic Brilliance Award-2014, Noida and has 08 years of teaching experience, scientific research and development. He has published 21 Books and 52 scientific research articles in international and national journals. His research has focused on the Graph Theoretical Analysis, Design, Insilico Modelling, Synthesis, Formulation and Analytical/Biological Screening of Novel Nano-composites.

Speaker
Panneer Selvam Kalasalingam University
India

Abstract

Transient receptor potential (TRP) cation channels are the largest group of sensory detector proteins expressed in the nerve terminals of many receptors including nociceptors, and are activated by temperature and chemicals that elicit hot or cold sensations. Antagonists of these channels are likely promising targets for new analgesic drugs at the peripheral and central levels. Because some non-steroidal anti-inflammatory drugs (NSAIDs) are structural analogs of prostaglandins and NSAIDs attenuate heat nociception and mechanical allodynia in models of inflammatory and neuropathic pain, we investigated whether three widely used NSAIDs (diclofenac, ketorolac, and xefocam) affect thermal and mechanical hyperalgesia following the activation of TRPA1 and TRPV1 channels. We measured nociceptive thermal paw withdrawal latencies and mechanical thresholds bilaterally at various time points following intraplantar injection of the TRPA1 agonists, cinnamaldehyde (CA) and allyl isothiocyanate (AITC) or the TRPV1 agonist capsaicin, or vehicle. When pretreated with vehicle, intraplantar injection of CA, AITC and capsaicin each resulted in significant decreases in thermal withdrawal latency and mechanical threshold in the ipsilateral hindpaw that did not return to baseline for more than 2 hr. To test effects of NSAIDS either diclofenac, ketorolac or xefocam was pre-injected in the same hindpaw 35 min prior to CA, AITC or capsaicin. Pretreatment with each of the three NSAIDs produced strong antinociceptive and antihyperalgesic effects lasting approximately 60 min. Thus, we show for the first time that local administration of NSAIDs suppresses thermal and mechanical hyperalgesia following TRPA1 or TRPV1 activation.

Biography

Merab Tsagareli has graduated from Tbilisi State University, Georgia (1977) and has completed his PhD from Lomonosov State University of Moscow, Russia (1982) and then postdoctoral studies from Serbsky Research Institute for General and Forensic Psychiatry in Moscow, Russia (1985-1990). He is the Director of the Pain and Analgesia Laboratory at Ivane Beritashvili Center for Experimental Biomedicine in Tbilisi, Georgia. His research focuses on the behavioral studies of TRP channels and analgesic and tolerance effects of NSAIDs in relation with the descending pain modulation system. He has published more than 100 papers in peer-reviewed journals.

Speaker
Merab Tsagareli Ivane Beritashvili Center for Experiemntal Biomedicine
Georgia

Abstract

Solid lipid nanoparticles (SLNs) are very potential formulations for topical delivery of antifungal drugs. Hence, the purpose of this research was to formulate the well-known antifungal agent Fluconazole (FLZ)-loaded SLNs topical gel to improve its efficiency for treatment of Pityriasis Versicolor (PV). FLZ -SLNs were prepared by modified high shear homogenization and ultrasonication method using different concentration of solid lipid (Compritol 888 ATO, Precirol ATO5) and surfactant (Cremophor RH40, Poloxamer 407). The physicochemical properties and the in vitro release study for all FLZ - SLNs were investigated. Furthermore, the optimized FLZ-SLN formula was incorporated into gel using Carpobol 934. A randomized controlled clinical trial (RCT) of potential batches was carried out on 30 well diagnosed PV patients comparing to market product Candistan ® 1% cream. Follow up was done for 4 weeks by clinical and KOH examinations. The results showed that FlZ-SLNs were almost spherical shape having colloidal sizes with no aggregation. The drug entrapment efficiency ranged from 55.49 to 83.04 %. The zeta potential values lie between -21 to -33 mV presenting good stability. FLZ showed prolonged in vitro release from SLNs dispersion and its Carbapol gel following Higuchi order equation. Clinical studies registered significant improvement (P < 0.05) in therapeutic response (1.4fold; healing%, 4 fold; complete eradication) in terms of clinical cure and mycological cure rate from PV against marketed cream. Findings of the study suggest that the developed FLZ loaded SLNs topical gels have superior significant fast therapeutic index in treatment of PV over commercially available Candistan® cream.

Biography

From May 1994-March 1996, worked as Quality Control Analyst (El-Nile Pharmaceutical Comp.), March 1996-August 1997,as Medical Representative (GlaxoWellcome Pharmaceutical Comp. ), August 1997- May 2002,as Demonstrator of pharmaceutics (Al-Azhar University , Faculty of Pharmacy, Pharmaceutics Department) May 2002-January 2005,as Lecturer Assistant of pharmaceutics(Al-Azhar University , Faculty of Pharmacy, Pharmaceutics Department ), January 2005-August 2005, as Lecturer of pharmaceutics ( Al-Azhar University , Faculty of Pharmacy, Pharmaceutics Department ), September 2005- February 2007, as Lecturer of pharmaceutics (October University For Modern Sciences & Arts (MSA) Faculty of Pharmacy ), April 2007 – September 2007 , as Honorary lecturer of Pharmaceutics (Manchester University, UK School of Pharmacy), February 2009- June 2009, as Lecturer of Pharmaceutics (Part Time) (Misr International University (MIU) Faculty of Pharmacy), April 2010-August 2010, as Assistant Professor of Pharmaceutics (Al-Azhar University , Faculty of Pharmacy, Pharmaceutics Department ), September 2010- August 2013,as Assistant Professor & Head of the Pharmaceutics Department (Modern University for technology and information (MTI), Faculty of Pharmacy), September 2013 join British University in Egypt BUE as Associate Professor and Acting Head of Pharmaceutics and Industrial Pharmacy Department, September 2015 as Professor and Head of Pharmaceutics and Industrial Pharmacy Department current

Speaker
Dalia AbdelRhman Ahmed Attia The British University in Egypt
Egypt

Abstract

Modafenil is a wakefulness promoting agent was initially investigated for the treatment of excessive daytime sleepiness (EDS) associated with narcolepsy and excessive day-time sleepiness (and fatigue). Modafinil is a white to off-white crystalline powder that is practically insoluble in water. This will affect its absorption and bioavailability. Most formulation in the market utilized the reduction of particle size to enhance solubility and bioavailability. In this study a slugging technique was used to develop a new formula with larger particle size possesses similar dissolution behavior as well as being bioequivalent to the commercially available modafenil (Provigil). Three slug weights were investigated primarily to evaluate effect on particle size. Slug weight 681mg was the best since no significant difference in the effect of the 3 weights. The effect of slugging (using slug weight 681mg) was investigated, to compare the single slugging process with the double and triple slugging processes. The double slugging technique gave faster dissolution than the single slugging technique while had no significant difference compared to triple.

Biography

DrOmari has completed his PhD in Industrial Pharmacy from Cairo University, Egypt 2003, MSc in Pharmaceutical Technology from Jordan University of Science and Technology 1995, Jordan and BSc in pharmacy from Yarmouk University, Jordan 1985. As an Assistant Prof.of Pharmaceutical Technology and Pharmaceutics in Faculty of Pharmacy/Yarmouk University since 2014, he currently, teaches different courses in Pharmaceutical Technology, Pharmaceutics and Physical Pharmacy. His main research interests are film coting technology, drug delivery systems and drug-excipient interactions. Currently he leads many researches in solventless coating, formulation of modafinil and mucoadhesive vaginal DDS. His experience was diverse and include both academic and industrial fields: Project manager in STD Co, asubsidary of Hikma PLC, Jordan 2003-08, Assistant Prof in Pharmaceutical Technology in Al-Israa University 2009-10, Al-Zaytoonah University 2011-12 and Al-Ahlyah Amman University 2013-14. Before, he was an officer pharmacist in Royal Medical Services, Jordan Armed Forces 1985-90 and Chief Pharmacist in many community and hospital pharmacies in private sector. He published many papers in reputed journals.

Speaker
Derar Omari Yarmouk University
Jordan

Abstract

Acute conjunctivitis (AC) is a common disease in both developing and industrialized countries. Conjunctivitis is an inflammation of the conjunctiva usually occurs as a result of infection or allergy, resulting in a so-called “red eye” or “pink eye.” Acute conjunctivitis can be viral in nature; however, as many as 78% of cases in children and half of cases in adults are caused by bacteria. Worldwide, there are an estimated 5 million cases of neonatal infectious conjunctivitis per year. It is usually a benign, self-limited condition. Two drugs though from different groups, both exerting antimicrobial action and are extensively used in acute bacterial conjunctivitis in Nepal Medical College. It will therefore be of interest to know the difference between the efficacies of these two widely utilized drugs. Ciprofloxacin ophthalmic solution (fluoroquinolones) and Tobramycin ophthalmic solution (aminoglycosides), which are the most commonly used as topical antimicrobial agent in context of Nepal.

Biography

I obtained MD in Clinical Pharmacology from Nepal Medical College Teaching Hospital (NMCTH), Kathmandu, Nepal in 2015. I obtained MBBS from Kathmandu Medical College Teaching Hospital (KMCTH), Kathmandu, NEPAL in 2006. Currently working as Lecturer at Patan Academy of Health Sciences (PAHS), Kathmandu Nepal. Worked as a tutor in Clinical Pharmacology before starting MD for 3 months in NMCTH. My trainings include Neonatal advanced life support in KMCTH, Interdepartmental clinical meeting on “Diabetics and Anesthesia” in KMCTH and advanced cardiac life support in Anesthesia in NMCTH. I have also done oral presentation at Las Vegas, USA in 2016.

Speaker
Mayuri Gupta Pathak Patan Academy of Health Sciences
Nepal

Abstract

Dyskeratosiscongenita (DC) is a rare genetic disorder in which patients suffer from progressive failure of highly proliferative tissues including the skin, blood, and intestinal epithelium. At the root of this disorder are loss-of-function mutations in genes critical for the function of the telomerase complex, resulting in critical telomere shortening and stem cell failure. Currently there are no therapeutic options for this debilitating disorder, and patients are treated primarily with bone marrow transplantation to restore hematopoietic function. Here, we generate mutation-corrected intestinal cells from DC patients by using CRISPR/Cas9-mediated homologous recombination in iPS cells followed by directed differentiation. We demonstrate that DC mutant cells have sub-optimal activity of the Wnt pathway resulting in intestinal stem cell failure, and that ectopic activation of the telomere capping protein and Wnt target gene TRF2 can alleviate the DC phenotype. Furthermore, using isogenic DC cell lines, we demonstrate that Wnt agonists restore TRF2 expression and reverse gastrointestinal phenotypes associated with DC, including intestinal organoid formation in vitro, and intestinal maturation in vivo. Thus, our isogenic DC cell model provides a platform for therapeutic discovery and identifies Wntagonism as a potential therapeutic strategy for treatment of DC patients.

Biography

Dr. Dong-Hun Woo is a Chief Technology Officer (CTO) at NEXEL Co., Ltd. Dr. Woo received his Ph. D. in stem cell biology from the Korea University. During this time, he worked on tissue regeneration through directed differentiation of human pluripotent stem cells into hepatocytes. After Ph.D. course, he initially extended his research into cancer stem cells, studying the molecular mechanisms underlying tumorigenicity of cancer stem cells in glioblastoma at the Lerner Research Institute of Cleveland Clinic in Cleveland, OH, USA. Then, he built on his expertise in stem cell biology human pluripotent cell fate specification by bringing genome editing strategies to bear on induced pluripotent stem (IPS) cell models of human genetic diseases in the University of Pennsylvania, PA, USA. His current project involves the generation of functional cells from human pluripotent stem cells for drug screening and toxicity tests as head of research programs in NEXEL Co., Ltd.

Speaker
Dong-Hun Woo Dong-Hun Woo
Korea (South)

Abstract

Crystallization is a widely used unit operation in the pharmaceutical and chemical industries. “Ibuprofen” which is a very popular analgesic. However, commercially available ibuprofen particles are needle like with rough surfaces and show poor flowability, poor compaction behavior and a tendency to stick to the tablet punches. To overcome these problems, a suitable size and shape of ibuprofen crystal is desirable that could be directly compressed with fewer operation steps (usually from 6 down to 2) but still having good product stability and therapeutic efficacy. A controlled crystallization process would be useful in producing such particles. Therefore to design a crystallizer to produce a desire size ibuprofen particle, the following information is needed, 1. Solubility diagram 2. Metastable zone limits 3. Crystal growth rates 4. Nucleation rates The methods used, the results obtained and the use of the data to design a crystallizer will be presented. It is shown that the solubility increases greatly with temperature, which means cooling crystallizers can be used industrially. The metastable zone (for secondary nucleation) is narrow yet growth rates in the zone are significant. The crystals show GRD (growth rate dispersion) while the growth kinetics are first order and probably kinetics controlled. Also a first order dependence of nucleation rate on supersaturation was found.

Biography

Speaker
Abdur Rashid Buraidah College of Pharmacy and Dentistry
Saudi Arabia

Abstract

Molecular cloning and structure-function studies on the Golgi-glycosyltransferases (GTs) and lactose synthase enzyme, a complex between beta-1,4-galactosyltransferase (b4-Gal-T1) and a protein alpha-lactalbumin (LA) that modulates the activity of b4-Gal-T1, has revealed that GTs have flexible loops. Upon binding of the sugar donor substrate the flexible loops of GT undergo a marked conformational change from an open to a closed conformation, repositioning the amino acid residues to lock the sugar donor ligand in place. This conformational change, in which the loop acts as a lid covering the bound donor substrate, creates an acceptor-binding site and the binding site for LA in the case of lactose synthase enzyme. After the glycosyl-unit is transferred from the sugar donor to the acceptor, the saccharide product is ejected and the loop reverts to its native conformation there by releasing the remaining nucleotide moiety. Generally the specificity of the sugar donor is determined by a few residues in the sugar-nucleotide binding pocket of the GT, conserved among the family members from different species. The mutation of these residues has allowed us to design new and novel glycosyltransferases which can transfer donor sugar with a chemical handle that have vast applications for the bioconjugation of drugs to antibodies via glycan chains and the detection of glycans on cell surface. The therapeutic cargo molecules conjugated to the glycan moiety of a monoclonal antibody generating antibody-drug conjugates (ADCs), are becoming powerful therapeutic tools for cancer treatment.

Biography

Dr. Qasba has completed his PhD from Muich University, Germany USA and postdoctoral studies from Max-Plank Institute of Biochemistry, Munich, Germany and from National Cancer Institute, NIH, USA. After working for 40 years at NIH he Retired as Chief of Structural Glycobiology Section, National Cancer Institute, NIH, USA and is currently working as a Special Volunteer Scientist. He has published more than 150 papers in reputed journals, written review articles, published a book on Conformation of Carbohydrates and has been serving as an editorial board member of BMC Biochemistry.

Speaker
Pradman Krishen Qasba National Cancer Institute
USA

Abstract

Fibrin has an important and vital role in blood coagulation. As a key protein in coagulation cascade, inhibition of fibrin activity is the goal of many therapeutic procedures. Peptides in recent years attract attention of researchers in medicine area. Mimicking the natural behavior of human body functions or inhibition of it for diagnostic or curing illnesses, peptides are now available in the market and searching for other ones is a hot research subject. In the field of molecular modeling, docking is a method which predicts the preferred orientation of one molecule to a second one when bound to each other to form a stable complex. In this research, six peptides are designed and docking performed for all of them using Hex software. The peptides are listed below: 1) Gly/pro/Arg/Pro/Ile/Leu/Glu/ 2) Cys/Gly/pro/Arg/Pro/Ile/Leu/Glu/Cys 3) Gly/Pro/His/Pro/Val/Val/Ser 4) Cys/Gly/Pro/His/Pro/Val/Val/Ser/Cys 5) Gly/Pro/Lys/Gly/Ala/Ala/Asp 6) Cys/Gly/Pro/Lys/Gly/Ala/Ala/Asp/Cys Docking results with Hex software for 6 designed peptides are shown in the table below. Molecule E Total E Shape H-bond RMS Peptide 1 -0.01 -0.01 -1 -1 Peptide 2 -0.06 -0.06 -1 -1 Peptide 3 -0.01 -0.01 -1 -1 Peptide 4 -0.02 -0.02 -1 -1 Peptide 5 -0.01 -0.01 -1 -1 Peptide 6 -0.02 -0.02 -1 -1 As it shown in table, E total and E shape of designed peptides are nearly the same as references' ones. It shows that designed peptides will have the ability to bind to fibrin and inhibit its function.

Biography

AtefehHajiagha Bozorgi has completed her PharmD from Tabriz university and her PhD from ShahidBeheshtiuniversity,Tehran,Iran. She is an assistant professor in Alborz University now and teaches medicinal chemistry courses for pharmacy student. She also manages hospital and educational pharmacies.

Speaker
Atefeh Hajiagha Bozorgi Alborz University of Medical Sciences
Iran

Abstract

The conduction of clinical drug trials involving patients leads to an understanding of previously not studied mechanisms of development, manifestations and consequences of diseases. Prior to the initiation of the research, the clinical trials project data is used by the Council on Ethics (CE) for the assessment of safety, effectiveness, accessibility and quality of new drugs produced either domestically or abroad.For the purposes of this study, a classification of the identified inconsistencies with ethical principles and the requirements of the current legislation on the nature, frequency and significance has been created based on the CE’s analysis of clinical trial data in 1690 casesthroughout 2016. Most of the concerns expressed by CE deal with medico-ethical problems (feasibility’s assessment of invasive procedures conduction: needle biopsy of the primary melanoma's tumor; possibility’s participationpatients in the post-natal period, etc.). The phone calls of patients received by CE have been processed with the causes of violation of the safety and legitimate interests of research participants properly marked.The analysis of errors and deviations makes it possible to generally outline the progress of preparation of clinical trial materials and how the trials are carried out in Russia. Hence the need arises for significant improvement of the quality of clinical trials organization, which is designed to properly secure the rights and dignity of the participants.

Biography

Khokhlov A. - MD, Professor, Head of the Department of Clinical Pharmacology of YSMU. Prof. Khokhlov completed the medical faculty and postgraduate education at the course of pharmacology of YSMU, furthermore he graduated from the Law faculty of International Institute of Economics and Law and is currently (the Vice Chair of the Ethics Council, Chief Editor of the journal of Medical Ethics, member of the Scientific Society of Clinical Pharmacologist of Russia). Chudova N. - Head of the Department review of clinical research FSBI«SCEEMP», Moscow. Tsyzman L. - Senior research associate of the Department review of clinical research FSBI«SCEEMP», Moscow.

Speaker
Lubov Tsyzman The Council on Ethics of the Ministry of Healthcare of the Russia
Russian Federation

Abstract

Introduction: The study was conducted to evaluate therapeutic efficacy of Artemether-lumefantrine (Coartem®) for the treatment of uncomplicated falciparum malaria in Wondogenet Woreda, Sidama Zone, Ethiopia. Since the spread of Plasmodium falciparum, parasite resistance to almost all antimalarial monotherapies is a serious impediment to malaria control. Artemether-lumefantrine (Coartem®) therapy has been in use as the first-line treatment for uncomplicated falciparum malaria since 2004 in Ethiopia. Methods: The study was designed according to WHO, 2003 study protocol. The study outcomes were classified into early treatment failure (ETF), late clinical failure (LCF), late parasitological failure (LPF) and adequate clinical and parasitological response (ACPR). Results: Primary study was conducted on ninety-nine P. falciparum mono-infected consenting patients who were enrolled in the 28-day in vivo Coartem® treatment followup study. Based on this, the overall cure rate for Coartem® was 98.9% (PCR uncorrected). The study also demonstrated 4.3% Plasmodium vivax and 2.2% P. falciparum/P. vivax co-infections at the end of followup period. Following Coartem® treatment, fever was cleared rapidly on days 1 and 2 and parasite clearance was high on days 1 and 3. Therefore, the study showed a high therapeutic efficacy of Coartem® for the treatment of uncomplicated falciparum malaria in Wondogenet Woreda. Conclusions: Coartem® had high efficacy for the treatment of uncomplicated falciparum malaria. It also had high efficacy with respect to clearance of fever and elimination of gametocytes within short period of time. The tolerability of Coartem® was very good with persistence of only minor adverse effects. The 1.1% LPF detected by the study and the occurrence of P.vivax / P.falciparum co-infection at the end of 28 follow up days require PCR confirmation.

Biography

Speaker
Esmael Besufikad Mizan Tepi University
Ethiopia

Abstract

Introduction In the oral inhalers, the particle size plays an important role in defining where the particles will deposit in the lung. Symbicort® Turbuhaler® is a combination of budesonide and formoterol[3]. Budesonide is provided as a mixture of two epimers, 22R and 22S. The budesonide epimer R is known to be 2 to 3 times more potent than the budesonide epimer S. In addition, formoterol is a long-acting selective beta-2 adrenoceptor agonist[3]. The Symbicort® Turbuhaler® shows flow–dependency for aerodynamic characteristics[5]. Also, the rate flow of each component may be different and therefore the pharmacological ratio may vary in delivery to the patient. As a result, it is essential to keep the combination ratio constant. The study aimed examine the effect of the flow rate on this combination. Methodology. In this experiment Anderson Cascade Impactor (ACI) has been used to assess the performance of Symbicort®. The ACI is an eight-stage cascade system intended for measuring the particle size distribution[2]. The amount of drug deposited in each stage was measured using the HPLC method of analysis which was developed and published. Result There are statistically significant differences for formoterol, budesonide R and budesonide S between 28.3L/min and 60 L/min in total emitted dose, fine particle dose (FPD) and the mass median aerodynamic diameter (MMAD). However, the ratio between the Symbicort combinations was constant at all flow rates. The effect of this was more obvious for the FPD and the throat deposition

Biography

DR. Mohammed Almeziny obtained his PhD, Pharmacy school, University of Bradford, Bradford, UK, he hold Essential Skills in Medical Education (ESME) certificate, Association for Medical Education in Europe, Dundee, UK and International Medication Safety Mentorship, Institute for Safe Medication Practices (ISMP), Horsham PA, USA Master of Sciences in Clinical Pharmacy, College of Pharmacy, King Saud University (KSU) Riyadh, Saudi Arabia. Bachelor of Pharmacy (BSPharm), College of Pharmacy,KSU He is currently the director of pharmacy services at Prince Sultan Medical Military City and he is an adjunct clinical assistant professor, college of pharmacy KSU. He is a consultant clinical Pharmacist Respiratory Unit

Speaker
Mohammed Almeziny Prince Sultan Military Medical City
Saudi Arabia

Abstract

Onosmabulbotrichum(OB)is a member of boraginaceae that well- known as a rich source of worthful secondary metabolites.Shikonin and alkanin derivatives have been identified as the bioactive constituents of this plant. This medicinal plant is used as suitable medicine for treatment of many disorders such as tumors, bronchitis, tonsillitis, hemorrhoids.However, biotechnological researches as a powerful tool have been applied in order to production and increasing of these valuable substances.Over the last decades, research projects have been studied for production of shikonin and its derivatives by tissue culture. In this study, according to rare geographical growing places of OB and farming problems large scale and economic shikonin production were impossible. We have investigated different methods of tissue culture of seeds of OB, prepare nano-fiber of shikonin extracted from callus culture of OB and evaluated their impacts on cancer cell line MCF7 and natural cell line HUVEC. Furthermore a semisolid dosage form has been prepared from callus culture and wound healing clinical animal studies was performed. The results established that shikonin and its derivatives production by callus culture were much more economic and they had good therapeutic effects on wound healing in rats. Shikonin extracted of callus loaded nano fiber also had more growth inhibiting effects on cancer cell lines in comparison to shikoninpresented in natural roots.

Biography

Reza Tahvilian, Ph.D. of pharmaceutics is an associate professor and member of school of pharmacy Kermanshah University of Medical Sciences, working on research pharmaceutical center and pharmaceutical department. Previously Dr. Tahvilian was vice president of Kermanshah University of Medical Sciencesin food and drug organization. He was also the chief manager of educational pharmacies in faculty of pharmacy. He is a lecturer and researcher in pharmaceutical technology and director of some projects and advisor in pharm D students. He has more than 10 patents and several paper publications about pharmaceutical sciences designed and prepared from herbal and synthetic medicines. Preparing novel drug delivery systems using herbal medicine and evaluation of their properties are main research project field.

Speaker
Reza Tahvilian Kermanshah University of Medical Sciences
Iran

Abstract

SodaSulphanecobalamin (Na4S5 CoC69N15H89O26) is an antidote for Chemical weapons mainly Classical chemical agent threat categories include vesicant or blister agents (e.g., sulfur mustard), blood agents (e.g., cyanide), respiratory agents (e.g., phosgene), and nerve agents (e.g., GA or Tabun, GB or Sarin, GD or Soman, and VX).It dissociate the toxic components in each chemical weapons, either nerves agent, blister agent or mustard gas to a non toxic substance when administered. It displaces the Cyanides to a free toxic compound, thiocyanocobalamin .It also added the amide group of protein when used. However, recent studies shows that this antidote can serve as a replacement for the antidote of Orange agent (2,3,4,7-tetra chlorobenzodioxin) which displaced millions of Vietnam Citizens during the world war II. Though Mercury (I) Oxalate is been used for this antidote for the orange agent, but we all know that Mercury is highly toxic and poisonous to the human. (Na4S5 CoC69N15H89O26) is produce by Hydroxocobalamin with the decomposition of Sodium nitrite and Sodium thiosulfate, which led to a faster return to baseline mean arterial pressure compared with sodium nitrite with sodium thiosulfphate; however, there was no difference between the antidote combinations in mortality, serum acidosis, or serum lactate (TERTSodium1,2-diithiosulphite-3,4diiintroso Co-α(α-5,6diimethlybenzylmizazonly)co-β-hydroxocobalamin) NO + Hocbl +2NaoH + NO2 +3Na2SO4 + Na2S5 2Na2S2O3 + 2NaNO2 + 4NaOH +HOSCb1 +SO2(g) Na4(S2O3)2 (NO2)2 C62H87 SCON13O16P The Antidotes develops the concepts, therapeutic regimens and procedures for the management of chemical warfare agent casualties; developing diagnostic and prognostic indicators for chemical warfare agent casualties; and developing life-support equipment for definitive care of chemical warfare agent casualties. Recent changes in the security situation facing the U.S. have not materially reduced the threat that chemical weapons present to American Forces in the field. Many countries and terrorist groups have the capability of producing and delivering chemical warfare agents, thus posing a substantial and serious threat to the Armed Forces of the U.S. Classical chemical agent threat categories include vesicant or blister agents (e.g., sulfur mustard), blood agents (e.g., cyanide), respiratory agents (e.g., phosgene), and nerve agents (e.g., GA or Tabun, GB or Sarin, GD or Soman, and VX). The most efficient and reliable way to treat chemical weapons is by using SodaSulphaneCobalamin. It is non-carcinogenic, non-mutagenic and non tarotogenic compound which is composition doesn’t has any toxicity and health effect when administered.It can also be used as any chemical based threat T his can been used against any chemical based threat

Biography

Expertise in quantum physics, also on determination of numerical value of dimension on physical quantities. Root mean square velocity and molecule velocity of all chemical elements which is never done before. stoichiometry and periodic properties table that shows the” INTRINSIVE AND EXTRINSIVE PROPERTIES” of all chemical elements. Determination of Molecular Mass and Formula for Air. Computational Mathematics and Application of Small organic Molecules. Antidote of chemical mass weapon (2,3,7,8 - Tetrachlorodibenzo-p-dioxin). Critical cGMP and ICH regulations for Pharmaceutical Laboratory. Pollution or environmental remediation studies, anthropogenic effect on petroleum. Synthetic of compound for biological evaluation. Synthetic of helium compound, which is another source of sun. Research on Oil Dispersant. Production of antidote of Cyanide Poisoning

Speaker
Salako N. Olatunji Federal Institute Of Industrial Research Oshodi
Nigeria

Abstract

Pulmonary drug delivery is a developing technology. Mainly, by using inhalation therapy via pressurized metered dose inhalers (pMDI) or dry powder inhalers (DPI). It is used mainly in treating some respiratory diseases including asthma, chronic obstructive pulmonary disease and cystic fibrosis. The lung provides an enormous surface area and relatively low enzymatic, controlled environment for systemic absorption of medications. As a result, the lung may be considered as a perfect site for drugs to pass into the systemic circulation. More recently, the inhalation of drugs were used as a new method of treatment for some of systemic diseases e.g. intranasal desmopressin. Usually, the inhaled drugs are more acceptable to patients than the injectable. A wide range of pulmonary delivery devices are currently available on the markets to carry drugs into systemic or local drug delivery systems in order to maximise drug delivery with low variability. Due to the drug formulation and the design of devices, different pulmonary delivery devices do not show the same performance. Therefore, healthcare providers need a basic understanding of aerosol science, inhaled formulations, delivery devices, and bioequivalence of products to prescribe these therapies optimally. The lecture will review the anatomy and physiology of the respiratory system, introduction to inhalation technology, lung deposition, methods of studying deposition, pulmonary delivery devices and the test methods that are specified by the regulatory bodies for approval of pulmonary delivery devices.

Biography

DR. Mohammed Almeziny obtained his PhD, Pharmacy school, University of Bradford, Bradford, UK, he hold Essential Skills in Medical Education (ESME) certificate, Association for Medical Education in Europe, Dundee, UK and International Medication Safety Mentorship, Institute for Safe Medication Practices (ISMP), Horsham PA, USA Master of Sciences in Clinical Pharmacy, College of Pharmacy, King Saud University (KSU) Riyadh, Saudi Arabia. Bachelor of Pharmacy (BSPharm), College of Pharmacy,KSU He is currently the director of pharmacy services at Prince Sultan Medical Military City and he is an adjunct clinical assistant professor, college of pharmacy KSU. He is a consultant clinical Pharmacist Respiratory Unit

Speaker
Mohammed Almeziny Prince Sultan Military Medical City
Saudi Arabia

Abstract

Cancer is the second leading cause of death globally, and was responsible for 8.8 million deaths in 2015. The development of novel molecules and targeted therapies has gained attention because of currently available chemotherapeutic methods of limitations such as side effects / toxicity of existing drugs, high metastatic rates, and drug resistance. The improvement of the design of metal-based therapeutic agents which have a very important role in cancer treatment, have been accelerated by the development of platinum complexes. In the treatment of anticancer properties of metal complexes many studies have been carried out on the development of new compounds with less toxic effect. Ruthenium is thought to have a lower side-effect profile, especially in platinum-resistant cancers and all other cancers, due to the greater accumulation of ruthenium, especially in cancer cells and hypoxic environments as well. Studies of anticancer and antimetastatic properties of ruthenium complexes have been published. Ruthenium complexes have been shown to be effective compounds in many cancers such as melanoma, lymphoma, breast and gastrointestinal cancers. It has been emphasized in many research articles that ruthenium complexes of phenanthroline-like compounds’ toxicity is lower and show higher cytotoxic and apoptotic activity as compared with cisplatin. In cancer, activation of tyrosine kinases and intracellular pathway increases proliferation and angiogenesis and prevents apoptosis. Sorafenib is a multikinase inhibitor that has been approved for renal cell carcinoma, hepatocellular carcinoma, thyroid cancer, and the study of Sorafenib continues in other types of cancers. Sorafenib, which inhibits tumor proliferation and angiogenesis, in addition to Raf kinase also inhibits receptor tyrosine kinases such as VEGFR, PDGFRβ, c-KIT, RET. Receptor tyrosine kinases play a role in many cellular events such as proliferation and differentiation, cell survival and metabolism, cell cycle control. The fact studies that obtaining new metal complexes of the known drug active substances and investigation of their activities enable to reach the new drug substance in a shorter time and a lower cost has led to a remarkable increase in the researches in this field. Based on this data, in this study, firstly Sorafenib and ruthenium complexes of Sorafenib bearing hetrocyclic structures prepared as regards to valuable literature datas. The structures of the obtained compounds elucidated by elemental analysis, NMR, UV-Vis, FT-IR and APCI-LC / MS methods. Biological activity studies of the obtained products performed. In this part of the study, MTT assay, cell cycle assay, apoptosis / cell death assay, in vitro tyrosine kinase assay, Western blot assay will be conducted. In addition, copolymers of poly (ethylene glycol) methyl ether-block-poly (D, L-lactate) (PEG-b-PLA) obtained to prepare polymeric micelles with active Sorafenib / metal complexes and drug release profiles examined. Finally, molecular modeling studies conducted by utilizing project outputs.

Biography

Kadriye Benkli has completed his PhD from Anadolu University Institute of Health Sciences, Turkey and postdoctoral studies from Leiden University, The Netherlands. He was the Dean of Inonu University Pharmacy Faculty, and now Professor at BezmialemVakifUniversity, Pharmacy Faculty, Pharmaceutical Chemistry Department. He has published more than 40 papers in reputed journals and has been serving as an editorial board member of repute.

Abstract

Since first introduction of topical steroids (TS) “in an early 1950’s”, it recorded the highest and most powerful impact to treat several dermatological problems other than group of drugs used in this case.(1). A study been conducted in UK revealed that 50% (out of 315 clients) used OTC topical steroids to treat eczema and dermatitis but they exceeded the limit of authorized treatment (2). Interruption of “nonmedical advisers” like friends and relatives has an effect on recommending TS as cosmetics in case of hyperpigmentation, acne or any skin irritation, without getting a proper advice from healthcare providers. Sharing the diagnosis and self-treatment with one who shares similar symptoms also has a great impact on topical steroids to be misused. Few studies have been done in UAE on the heavy use and mis-consumption of topical steroids in community pharmacy. This study is intended to examine the prevalence of topical steroids Vs. Emollients consumption in community pharmacy among 7000 clients in north region of UAE. Up on conclusion, 307 out of 7000 clients (4.3%) used topical steroids varied from betamethasone, cholesterol, mometason and hydrocortisone. 30% of topical steroids were prescribed by a doctor while 69.7% were taken without a prescription. Betamethasone was the highest topical steroids used (54.7%). 183 (2.6%) used emollients instead of topical steroids. 46.5% of 183 used prescription while 53.5% of them were self-medicated. Healthcare providers need to give full attention towards the increments in the consumption of topical steroids through proper counseling and use “Bioethics” concepts

Biography

Aya r. lafta has completed her Msc program from Ajman University of Science & Technology, UAE. She is pharmacist in charge at Medicina pharmacy-UAE .She has published 4 papers in reputed journals.

Speaker
Aya Rahman Lafta Medicina pharmacy
UAE

Sessions:

Abstract

Dynamic Light Scattering (DLS) is an analytical method that has been highly successful in analyzing colloids, proteins and other Nano-materials for 50 years. Detractors to the technology will say that it has several main failings, the predominant one being the need to dilute the sample before measurement. This is a major issue as many scientists/technicians historically have taken little or no care in how they dilute the sample. It is a prevalent tool for determining particle size distributions in fine particulate material suspensions, emulsions and colloids in general. Usually optical arrangements are used that demand dilution of samples. 180° backscattering, however, allows for considerably higher concentrations and is the right choice for concentrated samples which can occur in processes. The 180° backscattering we collect is especially suitable for direct in-line use in reactors, because the handling of the measurement probe head with a diameter of 8mm is just as easy as the insertion of a pH probe. A newly developed probe sheath effectively shields the natural Brownian motion from the process fluidics. At higher concentrations, where particle-particle interactions are present, on-line systems with automated dilution have been successfully implemented. External control of the DLS measurement software also allows for using robots in High-Throughput Screening (HTS) and fully automated formulation stations. Thus DLS has finally arrived as an automatized tool for both in and on line process and HTS.

Biography

David Pugh has completed his BSc from Aston University Chemical Engineering Department, Birmingham UK. He is the European Business Development Director of Microtrac GMBH,thetechnologically premier organization for providing solutions in particle characterization. He has been published and presented in more than 25 papers in reputed journals and international conferences on many multi-disciplinary subjects ranging from cosmetics, cement, coal, chocolate emissions to pharmaceutics. He has more than 35 years’ experience in providing technical solutions both in the laboratory and in real time process monitoring.

Speaker
David Pugh Microtrac GmbH
Germany

Abstract

The melanocortin system is composed of five receptors that are found throughout the body and are involved in many of the critical biological functions related to survival, health and disease. Despite its critical importance, there are only 2 drugs on the market, in large part because the ligands for these receptors are derived from a single gene POMC, which produces the hormones and neurotransmitters for these receptors, including alpha, beta and gamma–MSH and ACTH, all of which are highly nonselective and have short half-lives. Selective nonpeptides for these receptors have all failed in the clinic. To overcome these problems, we have developed a highly multidisciplinary approach, involving peptide and peptidomimetic design in three dimensional space, using both conformational and topographical considerations in phi, psi and chi space computational methods, and careful studies of downstream signaling. Using this comprehensive approach, we have designed potent, highly receptor selective, stable and bioavailable orthosteric and allosteric agonist and antagonist ligands for the MC1R, MC3R, MC4R and MC5R receptors, none of which interact with MC2R. Their application to pigmentary disorders, melanoma cancer detection and treatment, neurodegeneration and other biological functions will be discussed

Biography

Victor J. Hruby received his Ph.D. from Cornell University and did Postdoctoral studies with Noble Laureate Vincent du Vigneaud. He currently is Regents Professor at the University of Arizona, with major research interests in peptide hormones and neurotransmitters and their GPCR receptors, and their relationships to health and disease. He has over 1300 publications, chapters and reviews and over 25 patents. He has received numerous awards for his research, has been an editor and associate editor and on the editorial boards of several journals. He has served on several NIH Study Sections and been a consultant for many drug companies

Speaker
Victor J. Hruby University of Arizona
USA

Abstract

Background: Drugs have played a major role in defining the sub cultural and counter cultural influences in society. The pervasive availability of psychotropic chemicals can cause a direct physiological and psychological change in the body. The present work is aimed to use laboratory-based analyses to determine the prevalence and use pattern of some substances of abuse among a group of acute overdosed patients. Materials and Methods: The study was conducted on patients (n=390) with acute poisoning by some drugs of abuse (Cannabis, benzodiazepines, barbiturates, opiates and ethanol).The patients were from Dakahlia governorate and surrounding governorates. They were admitted to poison unit, emergency hospital, Mansoura University in the period between November 2009 and April 2014. In this study all patients were subjected for detection of drugs of abuse in urine by EMIT system and Gas Chromatography / Mass Spectrometry (GC/MS) for confirmation of the obtained results. Results: The study showed that approximately 75% of patients were encountered in the age group 20–40 years. Cannabis was the first abused drug (37.69%) followed by opioids (27.18%). Female patients were likely to abuse benzodiazepines (57.14%). The study revealed that the percentages of positive urine samples by EMIT were; (27.18%, 14.87%, 11.54% 9.74% and 1.79%), for cannabis, opiates, benzodiazepines, barbiturates and ethanol, respectively and by GC/MS were; 16.15%, 10.25%, 8.97% and 8.46% for cannabis, benzodiazepines, barbiturates and opiates, respectively. Conclusion: Presence of these drugs has a serious effect on man health (mental and physical functioning), consequently his environment.

Biography

Dr. RafaatAbd El-Dayem is an associate consultant (Professor) of Toxicology at the Emergency Hospital in the Faculty of Medicine at Mansoura University, Egypt. He obtained a PhD of hydro geochemistry in 2004, at Mansoura University and previously completed an MSC in hydro geochemistry in 2001 at the same institution. He also has a Diploma of toxicology and forensic chemistry (1996) from the Faculty of Medicine and a Diploma of applied chemistry (1993). Dr. Rafaatspecializes in medical analysis, toxicology & forensic chemistry as well as water pollution. He has published papers over 10 local paper and 13 in international publications. He has spoken at 55 local conferences and workshops and 15 international meetings. He is currently a member of eight international scientific societies.

Speaker
RAAFAT ABDELDAYEM Mansoura University
Egypt

Abstract

Background and the purpose of study. At present, pharmaceutical researchers are focusing on instantaneous intraoral dispersible technologies as novel drug delivery systems because; they have outstanding advantages over the traditional oral and parenteral routes of drug administration. Some essential natural drugs have low oral bioavailability due to extensive first pass metabolism and pre systemic degradation in the gastrointestinal tract. Aim. Now, a cheap rice paper Intraoral Dispersible Film (IDF) has been developed Objectives. In this study, formulation was optimized using the experimental factorial design. The IDFs were loaded with model, natural, anti-cancer drugs, Resveratrol and Curcumin with low oral bioavailability. Methods. They were evaluated for thickness, folding endurance, swelling behaviour, among others. These related to their drug release properties. Permeation was evaluated using the pig mucosal membrane mounted on a Franz diffusion cell. Taste testing was done to determine acceptability using a taste panel. Results and Discussions. Sixteen formulations showed variations in their profiles. Formulation 16 proved optimal. The dissolution rate at steady state concentrations of Resveratrol was 29mg per second and the Permeability coefficient was 389 mg/sec.cm2. Curcumin dissolution rate at steady state concentrations was 0.25mg per second and the Permeability coefficient was 42.71 mg/sec.cm2. Resveratrol permeability rate was 0.42 mg/sec. and that of Curcumin was 0.14 mg/sec. Resveratrol Flux was 0.21 mg/sec./cm2. Curcumin Flux was 0.14 mg/sec. / cm2. Drug entrapment was 80% for both molecules. The 20 mg of Resveratrol and Curcumin dissolved in 47.6 sec. and 71.4 sec. respectively. In this study, after permeation, a concentration of 6.73mg/ml of Resveratrol and 0.061mg/ml of Curcumin were detected after 2 hours of the experiment on administering only 20 mg of each of the drugs suggesting that Curcumin is 100 times less permeable than Resveratrol. The release profile was a “Burst release”. On contrast, Curcumin oral dose of 2 g/kg to rats yielded 1.35±0.23 µg/ml in 0.83 hours and in humans, given the same dose yielded either undetectable or extremely low (0.006±0.005 µg/ml after 1 hour in blood. Two separate mono-glucuronide metabolites yielded a Cmax of ~7.5 µM following a single 5.0 g oral dosage of Resveratrol. Conclusion. The key finding was, ex vivo release profiles of the optimized formulation revealed first order release and later zero order. Therefore, it is evident that rice paper IDF could efficiently deliver natural drugs into the systemic circulation intraorally. However, further studies need to be performed to prove increased bioavailability in human subjects

Biography

Mr. Mukasa Eliphaz is a Ugandan National and has worked at Medipharm Industries EA Ltd. Uganda factory as a Production supervisor for 15 years. He is specialized in cGMP and Oral Rehydration Salts Manufacture. He has studied at Mulago National Referral Hospital School of Dispensing for a Higher Diploma Pharmacy in 1988. He taught at Mulago Hospital Paramedical School for 2 years. He has attended a Clinical Instructor’s course at Mbale Health Manpower Development Centre in 1999 and worked as an Assistant Drugs Inspector at Uganda National Drug Authority for 7 years. He has also attended NIPER Chandigarh India for Assessment of quality of Pharmaceuticals. He did his B Pharm in 2012 at Nelson Mandela Metropolitan University (NMMU) Port Elizabeth South Africa and his M Pharm at the University of The Witwatersrand Johannesburg South Africa in 2016. He has worked at Johannesburg General Hospital Charlotte Maxeke for his Pharmacist Internship in 2013. He is an Honorary member of the Golden Key International South Africa. He presented his Research work at the 11th. World Drug Summit in Baltimore Maryland USA, 2017. Presently, he is doing his Pharmacist community service in the rural areas at Nessie Knight Hospital Sulenkama Qumbu in the Eastern Cape South Africa, where he is also a member of the clinical audit team.

Speaker
Mukasa Eliphaz Nessie Knight Hospital
Eastern Cape South Africa

Abstract

Many diseases, such as cancers, immune diseases, neurological and cardiovascular disorders, are the results of uncontrolled cell proliferations that escape Programmed Cell Death (PCD) regulation. Remarkable progresses have been made since 20 years to unravel, at the molecular level, the mechanisms by which an abnormal cell can escape PCD. However, decoding the human protein-protein interactome network highlighted the limit of therapeutic agents designed to interact with a single pathway, inevitably resulting in the activation of compensatory mechanisms, allowing diseases progression. Regardless, addressing an extracellular target located upstream of a signaling pathway and able to irreversibly trigger PCD might be efficient. With this aim, many studies are focusing on the multifaceted functionalities of thrombospondin 1 (TSP-1), identified as one of the endogenous ligand of CD47. The TSP-1/CD47 complex, for which a mechanistic calculation study has been reported,is implicated in diverse biological functions,including the direct induction of PCD. The design of TSP1 agonist peptide mimics therefore appears as a promising approach to restore PCD with applications to treat cancers and chronic inflammation related diseases.

Biography

Speaker
Philippe Karoyan University Pierre and Marie Curie
France

Abstract

The objective of this present work was to improve the aqueous solubility of poorly water soluble drug carvedilol. The major drawback of carvedilol is its aqueous solubility (25-30%), which results in poor bioavailability. To overcome these drawbacks, an attempt has been made to formulate solid dispersions of carvedilol using various ratios of β-Cyclodextrins by kneading method. The prepared solid dispersions have complied with the pharmacotechnical parameters. The FTIR and DSC studies revealed that there was no major interaction between the drug and carrier. The XRD results indicated that the drug was in amorphous form with little crystalline in nature. The in vitro studies for pure drug and solid dispersions were carried out in XXIII using double distilled water as dissolution media. The results revealed that the rate and extent of dissolution of drug from the solid dispersion were found to be faster than the pure drug. This could be due to lack of crystallinity, increased wettability and reduction in particle size of the drug in solid dispersion complex. The batch using drug carrier ratio (1:5) showed the maximum dissolution of drug (99.42%) as compared to pure drug (13.28%) at the end of 60 minutes. The results revealed that the prepared solid dispersions were found to follow first order kinetics. From the study it can be concluded that the formulated solid dispersions could enhance the aqueous solubility of carvedilol, which in turn it may increase the oral bioavailability of the drug.

Biography

Dr.D.Nagasamy Venkatesh has completed his Ph.D from The Tamil Nadu Dr.MGR Medical University, Chennai, Tamil Nadu in 2011 under the Faculty of Pharmacy. Presently, He is working as Assistant Professor at JSS College of Pharmacy, Ooty. Tamil Nadu. He has published more than 45 papers in reputed journals and has been serving as an editorial board member of peer reviewed international and national journal.

Speaker
Nagasamy Venkatesh JSS college of Pharmacy
India

Abstract

Buprenorphine and Fentanyl transdermal patches are used for the management of chronic intractable pain in both malignant and nonmalignant patients. Both Buprenorphine and fentanyl are potent opioids, but they have different pharmacology and toxicology properties. It is important to understand the difference in these properties as this information is useful for clinicians and pharmacists to use the opioid patches safely and effectively. Opioid analgesics mimic endogenous opioid peptides by causing a prolonged activation of opioid receptors (usually μ receptor). This receptor medicate analgesia, respiratory depression, euphoria and sedation. Fentanyl is potent, highly lipid soluble, rapidly acting μ-opioid receptor full agonist. Buprenorphine is a highly lipophilic semisynthetic opioid. It has complex pharmacology which is different from Fentanyl. Buprenorphine is a partial μ-opioid receptor agonist which binds to and activates a receptor but has only partial efficacy compared to a full agonist. This means that it may have ceiling effect and demonstrate both agonist and antagonist effects. In human studies using clinical effective analgesia doses, buprenorphine does not have a ceiling effect to analgesia. However, Buprenorphine does have a ceiling effect for respiratory depression. Hence, higher doses can be given with fewer respiratory depression side effect compared with higher doses of Fentanyl. The primary side effects of buprenorphine are similar to Fentanyl (eg, nausea, vomiting, and constipation), but the intensity of these side effects is reduced significantly compared to full agonist, Fentanyl. The most severe and serious adverse reaction associated with opioid use is respiratory depression, the mechanism is behind fatal overdose. Buprenorphine behaves differently than Fentanyl in this respect, as it shows a ceiling effect for respiratory depression. Buprenorphine has slow off rate (half-life of association/dissociation is 2–5 hours). The slow dissociation from μ-receptor accounts for its prolonged therapeutic effect for treatment of pain. Respiratory depression is rare with buprenorphine, but If occurs, it can be reversed by Naloxone, often larger doses are required than Fentanyl because buprenorphine dissociates slowly from the receptors. In conclusions, the pharmacology profile of buprenorphine is complex but unique, and contributes to its distinct safety and efficacy when it is used under appropriate clinical indications.

Biography

Christina Leung completed two Bachelor degrees in England, BSc Management Sciences degree followed by the BPharm Pharmacy degree. Following the registration as a pharmacist in the UK, she worked in different London Teaching Hospitals for 16 years. In the last 12 years in UK, she specialised in Paediatrics (especially in PICU and Paediatric Liver), Obstetrics and Gynaecology. She published two articles relating to drugs use in paediatric liver diseases in the UK Children Liver Diseases Magazine. Ms Leung is also a registered pharmacist in Hong Kong and she is currently working as the Senior Pharmacist (Clincial Pharmacy in Charge) at the HKU-SZH in China. She is also the Honorary Lecturer at the University of Hong Kong. She delivers lectures to the Master and Undergraduate Pharmacy students relating to Paediatrics, Obstetrics and Gynaecology.

Speaker
Christina Yuen Ki Leung The University of Hong Kong- Shenzhen Hospital
China

Abstract

Purpose This study aimed to determine university students’ knowledge, behavior and beliefs about breast cancer and breast self-examination (BSE). Method This is a cross-sectional and descriptive study. It was conducted in six universities in Palestine. The study sample involved950 female medical and non-medical university students who were randomly recruited to participate in the study. Forms for demographic characteristics data, knowledge and beliefsaboutbreast cancer and related risk factors, and knowledge and practice of breast self-exam were used for data gathering. Results Most participating students had low level of awareness of breast cancer risk factors. The most widely identified risk factor by the participants was smoking (72%) followed by genetic factors (51.7%) and oral contraceptive use (43.3%). Most of the participants (90.2%) identified breast lump as a symptom for breast cancer while only between 20% and 40% were aware of other warning signs. The most reported source for information regarding breast cancer was internet (64%) followed by friends (52%). Twenty two percent of participants correctly identified the suitable time to perform breast self-examination and only 4% reported performing it habitually every month. The most commonly reported reasons for not performing BSE were not having any signs of breast cancer (50%) and embarrassment (29%). Only 2% of participants believed that breast cancer is a punishment from God and most participants agreed that breast cancer patients should be provided with support and home care by the community (88%). Conclusion A profound gap of knowledge about breast cancer and its risk factors and BSE was seen among female university students. Awareness campaigns and educational programs have to be intensified to encourage women to engage in regular BSE.

Biography

Speaker
Mohammad Dweib Hebron University
Israel

Abstract

Introduction:Pressurised Metered Dose inhalers (pMDIs) emit an aerosol at high velocity and to be used properly they require co-ordination of inhalation and pMDI actuation. Spacer devices were introduced to improve the efficacy of inhaled therapy with pMDIs by decreasing the need for coordination between actuation and inhalation, so decreasing oropharyngeal deposition. In addition, particle size is obviously a crucial factor in inhaled drugs, affecting both the lung dose and delivery location and therefore clinical efficacy. However, there is considerable discussion about Spacer devices use and operation. AIM The aim of the study is to examine the effect of different type of spacers on pulmonary delivery to the patient from Qvar®. METHOD In this experiment Anderson Cascade Impactor (ACI) has been used to examine the impact of the type of spacer on pulmonary delivery to the patient. The ACI is an eight-stage cascade system intended for measuring the particle size distribution. The amount of drug deposited in each stage was measured using the HPLC. RESULTS Results showed that there were different effects on aerodynamic characterisation and the amount of drug available for inhalation when different spacers are used as inhalational aids. CONCLUSION The study results showed that experiments with one spacer cannot be extrapolated directly to other spacers or drugs, therefore it is necessary to test specific drugs and device combinations. In addition, the spacer leaflet should include the brand names of acceptable pMDIs with which it has been tested.

Biography

Biography DR. Mohammed Almeziny obtained his PhD, Pharmacy school, University of Bradford, Bradford, UK, he hold Essential Skills in Medical Education (ESME) certificate, Association for Medical Education in Europe, Dundee, UK and International Medication Safety Mentorship, Institute for Safe Medication Practices (ISMP), Horsham PA, USA Master of Sciences in Clinical Pharmacy, College of Pharmacy, King Saud University (KSU) Riyadh, Saudi Arabia. Bachelor of Pharmacy (BSPharm), College of Pharmacy,KSU He is currently the director of pharmacy services at Prince Sultan Medical Military City and he is an adjunct clinical assistant professor, college of pharmacy KSU. He is a consultant clinical Pharmacist Respiratory Unit

Speaker
Mohammed Almeziny Prince Sultan Military Medical City
Saudi Arabia

Abstract

We used organic liposomes (LP) to achieve specific delivery of anti-angiogenic tyrosine kinase inhibitor (sunitinib), targeting the expression of (Arg-Gly-Asp) RGD recognizing alphavbeta3 integrins by cancer cells and endothelial cells (ECs). Cytofluorimetric analysis and immunofluorescence studies highlighted that sunitinib cell-internalization was highly enhanced by the use of RGD-LP. ECs adhesion to vitronectinwas strongly inhibited by RGD-LP compared to the isolated RGD antagonist, pointing out the important role of multivalency of the nanocarrier. We found a synergistic inhibition of cell proliferation by the RGD-LP-sunitinib and a strong inhibition of VEGFR2 phosphorylation compared to untreated cells. Moreover, we found that RGD-LP-sunitinib strongly reduced in vitro tubulogenic activity of ECs and, in addition, RGD-LP-sunitinib reduced in vivo angiogenesis in mice exposed to RGD-LP-sunitinib compared to mice exposed to sunitinib or to the combinatorial treatment. Finally, we also found a RGD-dependent cell-internalization of sunitinib in mice bearing subcutaneous tumors of alphavbeta3 expressing B16 murine melanoma. In summary, the RGD-LP targeted delivery system has the potential for selective inhibition of angiogenesis and tumor growth. Moreover, the delivery mechanism presented here might be extended to different chemotherapeutic agents used for the treatment of different types of cancer.

Biography

Dr Bianchini has completed her PhD in Experimental Pathology at the University of Florence. Visiting Researcher at theCenter for Experimental Therapeutics & Reperfusion Injury, Brigham & Women's Hospital Boston, MA.Researcher at the Department of Biomedical, Experimental and Clinical Sciences, University of Florence. Dr Bianchini has published more than 60 papers in reputed journals.

Speaker
Francesca Bianchini University of Florence
Italy

Abstract

Getting better efficacy in bio-molecule interaction and biological properties by tuning the ligands in metal complexes is an important research area in metal based anticancer drug designing. In the present work, four [Co(L')(L'')2](ClO4), where, L' is acacen or phacacen Schiff base and L'' is heptylamine or dodecylamine, have been synthesized and characterized by various spectroscopic techniques. The DNA binding studies have revealed that the presence of phenyl group in Schiff base has made the complexes to effectively insert between DNA base pairs. Further the presence of long chain aliphatic amine at axial positions has induced intercalation to DNA via hydrophobic interaction. In the case of BSA binding, the electron withdrawing effect of phenyl moiety has increased the positive charge on metal center so phenyl group containing complexes have shown strong binding affinity with BSA. However long chain aliphatic amines have undergone more turn and twist during interaction with BSA. Therefore as the chain length increases BSA affinity decreases in phenyl group containing complexes. Theoretical results have well agreed with experimental results. Further their anticancer studies have shown that all the complexes are more potent than cis-platin and induce the cell death via apoptosis. The apoptotic cell death has been confirmed by various staining techniques such as AO/EB, hoechst and and Annexin V- Cy3. Furthermore the cell cycle analysis also determined by flow cytometry. The anti-angiogenesis study has indicated that all the complexes have inhibited the angiogenesis. Hence overall results warrant the present metal complexes for further in-vivo and clinical studies.

Biography

Dr. Sankaralingam Arunachalam has expertise in field of biophysical and biological studies of polymer drug conjugates and metallo-surfactants. More than 30 years, he has contributed remarkable ideas to the rational designing of polymer anchored metal complexes and surfactant metal complexes for chemotherapeutic designing. So for, he has published 77 publications with international repute. Fourteen students have obtained PhD under his supervision. He has actively participated and delivered his talks in various seminars and conferences.

Speaker
S Arunachalam Bharathidasan University
India

Abstract

The study of the stability of medicines is mandatory by International Conference on Harmonisation and World Health Organization. Rifaximin, an antimicrobial marketed in the form of tablets, has no record of stability studies. Thus, the objective of this work was to investigate the behavior and stability of rifaximin tablets for 6 months by the simultaneous conditions of temperature and humidity through UV, IR, HPLC and Turbidimetry techniques. After 6 months of stability study, rifaximin tablets showed to obey zero-order kinetics if analyzed by physico-chemical methods and second-order if analyzed by microbiological method. However, the UV method was not suitable for evaluation of rifaximin. Already, IR, HPLC and Turbidimetry methods can be used to evaluate the stability of rifaximin tablets. It is important to analyze products with more than one type of method before releasing results mainly in the case of antimicrobial products, in which the association of physico-chemical and microbiological techniques must be a rule. Rifaximin tablets may be considered stable after 6 months under conditions of 40 ºC ± 2 ºC and 75 % UR ± 5 % UR. Incompatible results in the analysis of doxycycline tablets and fluconazole capsules by different techniques are other examples of the importance of combining analytical methods for the correct and reliable evaluation of the quality of the final product.

Biography

Ana Carolina Kogawa graduated in Pharmacy-Biochemistry in 2008, and received her Master’s in 2012 and PhD in Pharmaceutical Sciences in 2015 from the Universidade Estadual Paulista – UNESP, Brazil. She has experience in managing people, lectures, quality tools and pharmaceuticals activities of industry with emphasis on quality control. She has published more than 30 papers in renowned journals and has been serving as a reviewer of manuscripts in more than 10 international journals.

Speaker
Ana Carolina Kogawa Universidade Estadual Paulista
Brazil

Abstract

Nano drug delivery systems are catching attention in biomedical applications because the drugs are at nano level, and are exposed more to the local site for better interactions. As a result the nano system functions efficiently for the desired application. Bulk wound healing materials are available in various forms to enhance the rate of wound healing. However faster and efficient wound healing is always anticipated. This can be achieved by nano systems, though people are working on the nanosystems, a new system with improved properties is being investigated. Our group is working on new and efficient wound healing materials using various eco-friendly polymers, to sustain the environment and patient compliance. Simple and easy technique was used for developing non-woven nanofiber mats. Gelatin, egg albumin, shellac, oil based polyesteramides, poly (curcumin acrylates), polyhydroxyalkonates, human serum albumen, poly(L-lactide), poly(ε-caprolactone), etc were designed and developed in the form of nanofiber mats immobilizing drugs. Evaluated morphology of the nanofibers, in vitro drug release kinetics and in vivo wound healing studies were done. Some of our findings in relation to wound healing material will be discussed.

Biography

Speaker
Rathna VN Gundloori National Chemical laboratory
India

Abstract

The use of metal complexes in antineoplastic chemotherapy has been continuously growing since the discovery of cisplatin by Rosenberg in 1965 and its FDA approval as a chemotherapeutic agent in 1979. According to the recent reports, cisplatin is one of the most widely used and world’s best-selling metal-based anticancer drugs. In spite of great success of cisplatin and similar compounds, they display cross resistance and several undesirable side effects. Another limitation of most chemotherapeutic drugs is poor water solubility.The major consequence of poor water solubility is the very low bioavailability of drugs. Therefore, one of the fundamental goals in current medicinal chemistry isnew approaches in designing of new anticancer drugs. On the other hand, metal complexes show ability to condense long strands of DNA into higher ordered three–dimensional structures which can be used in gene therapy.This aspect is a very important step in the design of efficient agents for DNA interactions. DNA condensation can be induced in vitro either by applying external force to bring the double helices together, or by inducing strong interactions between DNA andaffinitive materials. Consequently, nano-structured metal complexes have attracted increasing interest as a novel class of DNA condensing agent. According to the above explanations, one of the new, attractive, and promising approaches in both chemotherapy and gene therapy is the nanosuspension formulation of metal complexes.The use of nanoparticles for pharmaceutical applications have been investigated and reportedby our research group. The micro-particulate powder is transformed into nanoparticles by sonication. Suchnanosuspensionsconsistsonly the pure poorly water-soluble metal complexfree from any additional matrix material.

Biography

Bagher Amirheidari has completed his PharmD in Kerman University of Medical Sciences (KMU), Kerman, Iran and his PhD from the University of Manchester, Manchester, UK. He is the founder of the department of Pharmaceutical Biotechnology in the Faculty of Pharmacy, KMU. Dr. Amirheidari is also the CEO of Kerman Daroo Pajohesh (KDP), a start-up at Kerman incubator center. KDP is involved in development of API and pharmaceutical formulations. He has published more than 15 papers in reputed journals and has served as referee for many reputable journals.

Speaker
Bagher Amirheidari Kerman University of Medical Sciences
Iran

Abstract

Fast-dissolving formulations represent excellent opportunities for life cycle management to the pharmaceutical companies. Fast dissolving technologies have many advantages like ease of swallowing, administration without water, quick onset of action for improving both patient convenience and compliance as benefits for the patient; extended life cycle, product differentiation, patent protection as benefits for pharmaceutical companies... But there are some challenges for formulation development studies like taste-masking, disintegration time, moisture sensitivity, friability, packaging and intellectual property issues, especially for the generic companies. The technologies are under patent protection like Zydis ® , Flashtab®, OraSolv® and DuraSolv™, WOWTAB®.... One of the major issues is a taste-masking problem may be overcome with using cyclodextrins, polymer coating, flavoring&sweetening agent, microencapsulation techniques... There are some modified excipients for providing both tastemasking and productability properties in the formulation like Ludiflash®, Pharmaburst®... From the analytical development point of view, there are a number of different methods from conventional dosage forms which are determined in the Pharmacopoeias. And for comparison and assessment of taste masking, electronic tongue may be a good opportunity which was developed by Alpha M.O.S. In the sense of generic companies, developing a fast dissolving tablets version of an existing immediate-release product means that the two formulations must be bioequivalent and this can be challenging for in-vivo studies especially if the method of taste masking retards the dissolution rate of the active ingredient after disintegration. What about the future of fast dissolving technologies? Orally disintegrating extended Release (ODT-ER) dosage forms are providing all of the benefits of these two drug delivery technologies in a single pharmaceutical product. And oral rapid films also may be a good alternative, especially for the OTC market.

Biography

Gulay Yelken Demirel has a degree in Department of Chemistry from University of Gazi (Ankara, Turkey) followed by a master degree in Medicinal and Pharmaceutical Chemistry (faculty of pharmacy) from the same university and studied Executive Master of Business Administration at Istanbul University. Currently, She has an ongoing PhD in Medicinal and Pharmaceutical Chemistry(faculty of pharmacy) at Yeditepe University. She is also a Turkish Patent Attorney. She has eleven years experience in R&D department of generic pharmaceutical companies. She worked as formulation scientist at the Pharmaceutical Technology Department of Nobel Pharmaceuticals. Presently, She owns the R&D Project Group Executive position at Sanovel Pharmaceuticals. She has several published papers in the academic areas and over 100 patents&patent applications in the industrial areas on pharmaceutical dosage forms.

Speaker
Gülay Yelken Demirel Yeditepe University
Turkey

Abstract

This examination intends to research the inhibitory effect of soaker roots extricate s of Zingiber officinale on the increment of Staph. aureus that has been secluded from vaginal contaminations in vitro, in which it ended up noticeably drawn of Zingiber officinale, the utilization of ethanol 95%, wherein the furrow equip offer of extraction of 8% of the heaviness of dry powder has gone to a consideration slope of the drunk concentrate (10-100 ml/ml ) had been Picked successfully by agar gel diffusion method and utilization of microorganism Staphylococcus aureus in examination with ethylene glycol , wherein the outcomes confirmed that the breadths of the hindrance of advance of bacterial development raise with the consideration of alcoholic concentrate minimization, have been 10-20mg/ml low productivity and concentrations40-60 mg/ml medium conveying without hesitation, even as fixations 80-100 mg/ml changed into entirely effective and powerful contrary to the expansion of microorganism of Staphylococcus aureus

Biography

Speaker
Atheer Abdulhameed Khashan University of Anbar
Iraq

Abstract

The present work highlights the synthesis of a newer biologically active Mannich bases (4a-o) derived from (E)-4-((4-fluorobenzylidene)amino)-5-(pyridin-4-yl)-4H-1,2,4-triazole-3-thiol contributing benzo[d]thiazole, 1,3,4-thiadiazole and aminopyridine via N-Mannich reaction by conventional method as well as microwave heating approach as a part of an environmental benign synthetic protocol. All the synthesized compounds were characterized by spectral analysis and were screened for in vitro antimicrobial, antitubercular and antiprotozoal activity. Compound (4h) was found to be most active against E. coli and M. tuberculosis with MIC value 50 µM in the primary screening and were found to have encouraging activity against L. mexicana with MIC value 5.38 µM. Whereas N-Mannich derivative (4i) showed potency against L. mexicana and T. cruzi with MIC value 1.01 and 3.33 µM better than reference drug Miltefosina and Nifurtimox. To provide understandable evidence to predict binding mode and approximate binding energy of a compound to a target in the terms of ligand-protine interaction, all synthesized compounds were docked against an enoyl-[acyl-carrier-protein] reductase of M. tuberculosis (PDB ID: 4COD) and long peptide chain biotin carboxylase of E. Coli (PDB ID: 3JZF) as a biological target for docking study with the help of Schrodinger software using Glide, in which 4h docked with -9.19 and -8.620 docking score for PDB: 4COD and 3JZF respectively. Moreover, molecular dynamics (MD) simulations are performed for up to 50 ns simulation time investigating the stability of a ligand–protein complex. The computational studies revealed that Mannich derivatives have a high affinity toward the active site of enzyme which provides a strong platform for new structure-based design efforts. The Lipinski’s parameters showed good drug-like properties and can be developed as oral drug candidate.

Biography

Dr Navin Patel is a Professor and Head, Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat(India). Vice president: Indian Council of Chemists. 33 years of teaching and research experience, working with quinolones, quinazolinones, triazoles, oxadiazoles, thiadiazoles, pyridine, pyrimidinen etc related heterocycle by random synthesis, Microwave synthesis, molecular docking & stimulation studies moreover testing their biological activities. Guided 33 Ph. Ds. & 16 M. Phils. In synthetic medicinal Chemistry, published more than 130 research papers in national & International journals, reviewers of many reputed journals. Presented and given talks also chaired in many conferences.

Speaker
Navin B Patel Veer Narmad South Gujarat University
India

Abstract

Four polyketides were isolated from the algal-derived endophytic actinomycete Streptomyces sundarbansensis, which represents the lacking member in the recently reported series of phaeochromycins A–E. We also proposed a method based on the comparison of experimental IR spectra with the DFT ones calculated in order to establish the tautomeric forms for these metabolites. The results indicated a γ-pyrone structure for these compounds, in analogy to the related polyketides mutactin and SEK34. Due to this study, it is possible to suggest that also the known phaeochromycins were isolated mainly in this tautomeric form, differently by the structures reported until now. Evaluation of IC50 values on the pure and structurally defined metabolites as inhibitors of Gram positive and Gram negative bacteria, from where the new compound showed the highest and selective antibacterial activity against MRSA

Biography

Speaker
Mouloud KECHA A.MIRA University
Algeria

Abstract

In terminally ill cancer patients approaching the dying phase, liberal use of antimicrobials is often viewed by palliative care experts as irrational. No previous reports have reviewed current antimicrobial use in palliative care settings in Saudi Arabia. The objective of this study was to explore the pattern of antimicrobial use in a tertiary palliative care unit (TPCU) during the last week of patients’ life. Medical records of all patients who died in the TPCU over a 14-month period were reviewed for demographics as well as the frequency and rationale of antimicrobial use during the patients’ last week of life. Information on antimicrobial use was obtained from a computerized pharmacy database. Of 138 patients who died with advanced cancer in the TPCU, 87 (63%) were on one or more antimicrobials during their last week of life. Antibiotics were more frequently used as compared to antifungal and antiviral agents, 64 (46.4%); 45 (32.6%); and 2 (1.5%), respectively. About one third (31.3%) of patients who received antibiotics during their last week of life were prescribed more than one antibiotic. Antimicrobials were mostly given systemically (79%) rather than topically (21%). The most common rationales for antimicrobial prescribing were oral thrush in 36 patients (25.4%), wound care in 29 patients (20.4%), and on empirical basis in 29 patients (20.4%). Conclusions: The current practice of antimicrobial prescribing, especially for patients who are eminently dying, may need to be reviewed. Initiation of antimicrobial treatment in this group of patients should be based on clear treatment goals and desired outcomes, considering views of patients and families.

Biography

Mohammed Abduh Alshaqi is a Consultant and Head of Palliative Medicine, division of Oncology Department at Prince Sultan Military Medical City at Riyadh, Saudi Arabia. He completed his MBBS from King Saud University 1992/1993, Arab Board of Family Medicine 2001, then Palliative Care from Canada and King Faisal Specialist Hospital & Research Center at 2006 and 2008. He is a member of many affiliations and societies like American Academy of Family Physicians and Saudi Society of Family and Community Medicine since 2001. In addition to that, he is a Member of Middle East Academy of Medicine of Aging (MEAMA) since 2003, Member of International Association for Hospice and Palliative care since 2006, Member of Saudi Oncology Society since 2008, member of Saudi Pain Society since 2009, Member of Group on Educational Affairs (GEA) for Medical Education Research Program (MERC) since 2011, and Member of Arab Society of palliative care since 2014 till present. Dr. Alshaqi is a trainer and external examiner of Palliative Medicine of Saudi Commission for Health Specialties and Acting director of Saudi Society of Palliative Care since 2013 till present.

Speaker
Mohammed Abduh Alshaqi Prince Sultan Military Medical City
Saudi Arabia

Abstract

Statement of Problem:Oral antiplatelet and anticoagulant drugs are commonly prescribed to patients with cardiovascular diseases. Despite being life-saving, these drugs have one major adverse effect that they can cause spontaneous hemorrhage, which can be fatal. Development of a hemostatic agent can help in quick and effective management of drug-induced hemorrhages. Objective:This study was devised to observe the effect of leaf extract of Justicia adhatoda on coagulation profile in mice and to evaluate its effect on in-vitro platelet aggregation. Methods:The study was divided into three parts. First part was designed to evaluate the effect of different doses of leaf extract of J. adhatoda on bleeding time in mice. Dose that produced maximum decrease in bleeding time was chosen for further in-vivo coagulation studies.Second part of the study was to observe the effect of J. adhatoda leaf extract on coagulation parameters. Three drugs were used to induce coagulopathy viz., warfarin, aspirin and dabigatran. Bleeding time, platelet count, PT, INR and APTT were estimated.Third part of this study was devised to observe the effect of J. adhatoda leaf extract on in vitro platelet aggregation. Percent aggregation was recorded by light transmission aggregometer for three minutes. Results:Leaf extract of J. adhatoda decreased bleeding time in mice. There was no effect on the coagulation parameters. Platelet count increased significantly only in the aspirin treated group that received the extract. Platelet aggregation increased in a dose dependent manner. Conclusion:J. adhatoda leaf extract is effective in controlling excessive bleeding due to aspirin induced platelet dysfunction, but has no role in reversing the anticoagulant effect of warfarin and dabigatran.

Biography

Dr Sehrish Zaffar (MBBS, M. Phil) has an outstanding professional record. Best graduate of her MBBS class with 12 gold medals and 2 silver medals. Completed her M. Phil degree with 81% marks. She is currently working as Assistant Professor of Pharmacology in CMH Medical College, Lahore, Pakistan. She has immense passion and potential towards pharmacological teaching and research. She has 2 years’ experience in teaching and research. During this time, she has published two articles and completed research work of the above mentioned abstract. She is also currently working on two other research papers. In near future, she is interested in applying for PhD in Pharmacology and has prepared the research proposal for that. Therefore, excellence in career with utmost hard work and continuous efforts is her topmost priority.

Speaker
Sehrish Zaffar CMH Medical College
Pakistan

Abstract

Management is a social process manifested on the market. Rather than in an isolated vacuum, organizations operate in a complex dynamic environment. Organizations’ efforts are aimed at using business opportunities and averting (or neutralizing) dangers. A substantial number of top organizations are engaged in continuous efforts to influence a large number of factors from their environment so as to channel (or harmonize) their state and movement with their own interests. Within any organization, marketing bears the greatest responsibility for making insights into the environment and responding to challenges they face. A substantial part of sources dealing with the basics or principles of marketing is devoted to the analytic definition of environmental forces making a direct or indirect impact on business operations.

Biography

Speaker
Veselin Dickov Institute for the Health Protection of Students
Novi Sad
Serbia

Abstract

Self-medication (SM) is highly prevalent in the Middle East. However, regulations in the Middle East are not always enforced and therefore many prescription medicines can be purchased as SM, resulting in potential abuse of many medicines. The aim of this article, therefore, was to undertake a comprehensive review to identify the different types of self-medications involved in abuse in the Middle East and to identify harms related to SM abuse. Method: An extensive review of the published literature pertaining to the subject (1990–2015) was conducted using PubMed, Web of Science, Cochrane and Google Scholar databases for OTC medication abuse in the Middle East. Results: Twenty-two papers were identified. Medications involved in SM abuse included: psychoactive prescription-only medicines, codeine-containing products, tramadol, anabolic steroids, sedative antihistamines, decongestants and laxatives. Moreover, studies in the region rarely reported harms related to SM abuse and strategies to limit this abuse. Conclusion: Potential SM abuse involving a range of medicines is a public health problem in the Middle East. Future interventions and regulations should be applied to limit the expansion of SM use and potential abuse.

Biography

Speaker
Malak Khalifeh Bordeaux University
France

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