Scientific Program

Keynote Talks

Abstract

Connectivity studies using resting-state functional magnetic resonance imaging (rsfMRI) data have enhanced our knowledge on the organization of large-scale structural and functional brain networks, which consist of spatially distributed, but functionally linked regions that continuously share information with each other. Brain's energy is largely consumed at rest during spontaneous neuronal activity (~20%), while task-related increases in metabolism energy are minor (<5%). Spontaneous low-frequency correlated fluctuations in blood oxygenation level dependent (BOLD) rsfMRI signals at the level of large-scale neural systems are not noise, but orderly and organized in a series of functional networks that permanently maintain a high level of temporal coherence among brain areas that are structurally segregated and functionally linked in resting-state networks (RSNs). Some RSNs are functionally organized as dynamically competing systems both at rest and during task-related experiments. The default mode network (DMN), the most important RSN, is involved in realization of tasks like memory retrieval, emotional process, and social cognition. Cortical connectivity at rest was reportedly altered in several neurological and psychiatric disorders. Most recently, human brain function has been imaged in fMRI, and thereby accessing both sides of the mind-brain interface (subjective experience and objective observations) has simultaneously been performed. As such, functional neuroimaging moves onto new potential applications like reading the brain states, brain-computer interfaces, lie detection, aso. The present contribution aims to highlight the fundamentals and review the up-to-date findings in imaging modalities dedicated to brain connectivity and, more generally, to connectomics on the basis of diffusion tensor imaging (DTI) for white matter (WM) and rsfMRI for grey matter (GM) studies, respectively.

Biography

Radu Mutihac is Chair of Medical Physics Section, University of Bucharest, and works in Neuroscience, Signal Processing, Microelectronics, and Artificial Intelligence. As postdoc/research associate/visiting professor/full professor he run his research at the University of Bucharest, International Centre for Theoretical Physics (Italy), Ecole Polytechnique (France), Institut Henri Poincare (France), KU Leuven (Belgium). Data mining and exploratory analysis of neuroimaging time series were addressed during two Fulbright Grants in Neuroscience (Yale University and University of New Mexico). His research in fused biomedical imaging modalities was carried out at the Johns Hopkins University, National Institutes of Health, and Walter Reed Army Institute of Research, MD, USA. Prof. R. Mutihac is member of the ISMRM, ESMRMB, OHBM, Romanian US Alumni Association, and fellow of Signal Processing and Neural Networks Society IEEE, as well as referee for several journals of the Institute of Physics (London, UK), Neural Networks (Elsevier), IEEE Transactions on Image Processing, and evaluator/expert for the ISMRM, OHBM, ARACIS, CNCSIS, UEFISCDI, The Romanian U.S. Fulbright Commission. and the European Commission (FP7, H2020). He published over 100 scientific papers, 12 monographs, and contributed with chapters in other 10 text books. He participated to more than 150 scientific meetings with posters and oral presentations, seminars, invited and plenary lectures, as well as acting as organizer, chairman, and keynote speaker. Following his scientific activity, Prof. Radu Mutihac was nominated member of the Editorial Board of six journals in the field of Neuroscience: Journal of the Romanian College of Medical Physicists, Epilepsy Journal, Journal of Childhood & Developmental Disorders, Journal of Neurology and Clinical Neuroscience, Medical and Clinical Reviews, The Neurologist - Clinical and Therapeutics Journal.

Speaker
Radu Mutihac University of Bucharest
Romania.

Abstract

Despite decades of investigations in both laboratory and clinic, the pathophysiological mechanism of Alzheimers disease (AD) still remains unknown. Current problem of developing AD research is that many treatments have been found to be very effective in AD animal models but they failed show significant effects in clinical trials. Thus, establishment of an effective treatment in a model, which represents pathophysiology of AD is needed. Previously, we were able to show improved cognitive function of aged, memory-impaired animals through the implantation of human neural stem cells (NSCs), which produced much excitement throughout the research world and the overall medical community; given the implication that this could lead to a cure for all neurodegenerative diseases, including AD. However, when we transplant NSCs to a transgenic animal model produces Amyloid-β (Aβ) plaque formation in the brain by expressing familial AD mutant amyloid precursor protein (APP), mimicking the pathological condition of AD, we did not find any new neuronal development formed from the donor cells. This indicates that transplantation of NSCs by itself may not be a cure for AD. Here we show that the combination drug therapy therapy of Posiphen (reduce APP level) and NBI-18 (increase endogenous neural stem cell) increased neurogenesis and significantly improved memory in the transgenic AD mouse model. This combination therapy could bring us an effective treatment for AD.

Biography

Sugaya is a professor in University of Central Florida. He have interests in treating neurodegenerative diseases by stem cell technologies, and his work at UCF has been introduced by Wall Street Journal and other media. He is a Director of the Stem Cell Laboratory and Director of the Neuroscience Consortium for Central Florida. He is also serving as a Council member of the Florida State organization, the Center for Universal Research to Eradicate Disease. His laboratory, which consists of 26 people in the Biomolecular Science Center, College of Medicine, is very active. His team published 16 papers, and filed 31 patents since he moved to UCF. Now they are conducting totally new research in the animal to treat neurodegenerative diseases including Alzheimers disease, Parkinsons disease and stroke in animal studies using adult human stem cells, which eliminate ethical issues and many other concerns associated with embryonic stem cells. One of the research goals is to produce brain cells from the patients own adult stem cells, and another is to increase endogenous stem cells by systemic administration of a drug. The research teams also recently succeeded in producing retina and inner hair cells from adult human stem cells to treat blindness and deafness. Dr. Sugaya is collaborating with many institutions including the National Institutes of Health, Florida hospital and the Karolinska Institute in Sweden and is aggressively investigating cures for diseases associated with aging.

Speaker
Kiminobu Sugaya University of Central Florida
USA

Abstract

Will be update soon...

Biography

Rajendra D. Badgaiyan is a psychiatrist and cognitive neuroscientist. He is Chairman of the Department of Psychiatry and Behavioral Sciences at Richmond University Medical Center, and Professor of Psychiatry at Icahn School of Medicine at Mount Sinai in New York. He received formal training in psychiatry, psychology, cognitive neuroscience, molecular imaging and neuroimaging. He was awarded the prestigious BK Anand National Research Prize in India and Solomon Award of Harvard Medical School. His research is focused on the study of neural and neurochemical mechanisms that control human brain functions. He developed the single scan dynamic molecular imaging technique (SDMIT) to detect, map, and measure neurotransmitters released acutely in the human brain during task performance. This technique is now used in laboratories all over the world. Using this technique, he studies dopaminergic control of human cognition and behavior. He is also interested in learning the nature of dysregulated dopamine neurotransmission in psychiatric and neuropsychiatric conditions. His research is funded by NIMH, NINDS, VA, and various foundations. Previously he served in the faculty of Harvard Medical School, SUNY Buffalo and University of Minnesota. He has published extensively in peer-reviewed journals.

Speaker
Rajendra D. Badgaiyan Richard University Medical Center
USA

Abstract

Will be updated soon...

Biography

Janna GLOZMAN is a full professor at Psychology Department of Moscow State University (Russia). Disciple of A.R. Luria she works there from 1970 till now, teaching neuropsychology, neurogeriatrics, neurolinguistics, learning disabilities, communication disorders. Scientific Director of Moscow Research Center of Developmental Neuropsychology, named after A.R. Luria. President of the International Society of Applied Neuropsychology (ISAN). Honorary Member of Polish Neuropsychological Society. Janna Glozman is the author of 40 books and 450 articles and abstracts of reports in Russian, English, German, Polish, Spanish, French, and Portuguese. J. Glozman took part more than in hundred international congresses. Emerite Scientist of Moscow University.

Speaker
Janna Glozman Moscow State University
Russia

Abstract

The book, The Intuitive Rational-Choice Theory: Schizophrenia, Criminal Inanity & Neuroses, presents a new theory which explains the development and treatment of schizophrenia and criminal insanity as rational coping mechanisms. Based on the strong relationships between schizophrenia and neurological impairments, medical models took for granted that all cases of schizophrenia result from neurological impairments, even when there was no evidence, as in the case the Unabomber and John Nash. The new theory, termed also Psych-Bizarreness Theory, demonstrates that it can explain all cases of schizophrenia, regardless whether they suffer from neurological damages or not, as well as criminal insanity and neurotic disorders, by conscious-rational terms. According to the new theory, when individuals are confronted with extreme levels of stress, irrespective of whether the source of the stress is neurological or environmental, their behavioral options become limited: They can commit suicide, develop a drug abuse, use aggression to eliminate the stressor, or intuitively choose certain mad/bizarre behaviors diagnosed by five empirical criteria (Rofe, 2000, 2016), that suite their coping demands. Madness is seen primarily as a repressive coping mechanism, which individuals intuitively choose when confronted with unbearable levels of stress. Thus, contrary to psychoanalysis, madness cause repression rather than visa versa. The choice of a specific mad behavior is determined by the same three principles which guide the consumer's decision-making process when purchasing a certain product. The major principal is the need controllability: The specific mad behavior must increase the patient's ability to exercise control over the stressor and\or provide certain desired privileges. The second guiding principle is availability: The choice of the specific symptom is affected by various channels of information, such as the media, personal experiences, genetic predispositions, family and peers that increase the saliency of certain suitable behaviors. The third principle is cost-benefit analysis: The mad behavior is chosen only if the individual intuitively feels that it will reduce the level of his or her emotional distress. Although the decision to implement the intuitive/unconscious choice is conscious, patients become unaware of the Knowledge of Self-Involvement (KSI) through a variety of cognitive processes that disrupt the encoding of this knowledge and a number of memory inhibiting mechanisms that cause its forgetfulness. Subsequently, utilizing their socially internalized beliefs regarding the causes of psychological disorders, patients develop a self-deceptive belief which attributes the cause of their symptoms to factors beyond their conscious control. The new theory proved its ability to integrate all therapeutic methods pertaining to neurosis into one theoretical framework (Rofe, 2010), explaining all data relevant to the development and treatment of conversion disorder, including neurological findings, which seemingly support the medical explanation of this disorder (Rofe & Rofe, 2013), and resolves the theoretical confusion regarding the explanation of phobia by distinguishing between bizarre (e.g., agoraphobia and chocolate phobia) and non-bizarre phobia, such as dog phobia (Rofe, 2015). Robert Aumann, the Nobel Prize-winning economist, noted in a letter of recommendation to publishers of the present book (2017), Rofes theory is as "revolutionary as it sounds, fits well into the frameworks of economics, game theory, and evolution".

Biography

Yacov Rofe is a professor of psychology and former chair of the Interdisciplinary Department of Social Sciences at Bar-Ilan University in Ramat Gan, Israel. He taught for the Department of Psychology at Washington University in St. Louis, Missouri, and was a visiting professor at Rutgers Medical School in New Jersey. He has published many articles in leading academic journals of psychology, including a theory entitled Stress and Affiliation: a Utility Theory, published by Psychological Review in 1984. An additional influential article, published in Review of General Psychology, 2008, is a review that refutes the existence of repression and the Freudian Unconscious.

Speaker
Yacov Rofe Bar-Ilan University
Israel

Abstract

Cdk5 is a proline-directed serine/threonine kinase that is increasingly implicated in various nervous system functions during nervous system development and function. It is a multifunctional kinase, however, upon deregulation due to neuronal insults induces neurodegenerative diseases such as, AD, PD and ALS. Cdk5 is a member of cyclin-dependent kinases. It is unique among its family; it is not activated by cyclins but is regulated exclusively by the brain-specific activator proteins p35/p39, p25, p67. Emerging evidence suggests that abnormal and hyper Cdk5 activity is implicated in the accumulation of neurofibrillary tangles in AD, synuclein in Lewy bodies in PD, and in inclusions of aberrant phosphorylation of neurofilament and Tau proteins the hallmarks of AD patients. Our recent studies have shown that a modified truncated 24-aa peptide (TFP5/TP5), derived from the Cdk5 activator, p35, penetrates the blood-brain barrier upon i.p. injections, inhibits abnormal Cdk5 hyperactivity, and significantly rescues AD pathology (up to 70 to 80%) in 5XFAD and P25Tg AD model mice. In this study, the mutant mice were injected with TFP5 and exhibited behavioral rescue and reduced pathological markers significantly; decreased inflammation, amyloid plaques, NFTs, cell death, and extended life by 2 months. However, no toxic side effects were observed. Interestingly, Cdk5 has been also demonstrated to exhibit a critical role in mitochondrial function, autophagy induction and neuronal loss in MPTP and other neurotoxic reagents-mediated neuronal toxicity mitochondrial dysfunction. These results point to TFP5/TP5 as a potential therapeutic, toxicity-free neuroprotective drug candidate. Cell biological neuroprotective protective and restoratives role of TP5/TFP5 will be presented and discussed.

Biography

Pant received his M.A. and Ph.D. degrees in Physics from Agra University, Agra, India. His postdoctoral studies were conducted on the mechanisms of electron and ion transport in model membrane systems at the Department of Biophysics at Michigan State University. He joined the Laboratory of Neurobiology in the NIMH as a senior staff fellow in 1974 with Dr. Ichiji Tasaki where he studied the function of the axonal cytoskeleton in the squid giant axon. In 1979 he moved to the NIAAA extending his studies on the neuronal cytoskeleton and the effects of alcohol on its regulation. Dr. Pant moved to the NINDS, Laboratory of Neurochemistry in 1987 where he is presently chief of the section on Cytoskeleton Regulation. His laboratory is studying the mechanisms of topographic regulation of neuronal cytoskeleton proteins by post-translational modification, including the role of kinase cascades in normal brain and during neurodegeneration.

Speaker
Harish C. Pant National Institute of Health
USA

Abstract

The currently dominant hypothesis for the pathogenesis of Alzheimer disease (AD) is that either amyloid itself or oligomers derived from the amyloid precursor peptide (APP) are causal. Strong data support their roles. Nevertheless, there are reasons to doubt their unique importance. Not only are there exceptions to their having sole participation, but there is also much evidence for contributions to pathogenesis by several subcellular reactions in neurons, astrocytes and endothelial cells. Moreover, for almost no disease is there only one pathogenetic factor; it is usually a + b + c .etc. The model for AD proposed in this lecture is that both amyloid and APP oligomers are important yet alone, without co-factors, are inadequate to reach the threshold for causing dementia; that threshold is reached with the addition of one or more subcellular reactions. Those subcellular reactions involve tau protein, mitochondria, the unfolded protein response, the ubiquitin/proteasome system, the Wnt/catenin and notch signaling systems, and calcium homeostasis. Thus, the pathogenesis of AD is multifactorial. Eight available drugs might benefit the involved subcellular systems; they should be used in combinations of three or four of them because in any particular case of AD it is not possible to know which system or systems are at fault. Finally, no scientific hypothesis has worth unless testable; the structure of a clinical trial to test the proposed model will be described.

Biography

Prof. W Jeffrey Fessel born in London 1932. University College HospitalMedical School, London. Fellowship in Rheumatology, University of California, San Francisco. Chief, Dept of Medicine, Kaiser Permanente Medical Care Program, 1979-1989. Director, Clinical Trials Unit, Kaiser Permanente Medical Care Program, 1991-present. Professor of Clinical Medicine, University of California, San Francisco, 1983-present. Listed in "Whos Who in America", 2005-present (Marquis).Listed in "Whos Who in the World", 2005-present (Marquis). Research in schizophrenia, Dept Psychiatry, University of California 1959-65. Since 1991, conducted clinical trials in gout, osteoarthritis, rheumatoid arthritis, HIV/AIDS, hepatitis C, hepatitis B. >140 publications concerning schizophrenia, autoimmune diseases, HIV/AIDS, hepatitis C, hepatitis B, and Alzheimers disease. Fessel WJ, Concordance of several subcellular interactions initiates Alzheimers Dementia: their reversal requires combination treatment,Amer J Alzheimer's Dis Other Dementias, 2017;32:166-181.Fessel J, Amyloid is essential but insufficient for Alzheimer causation: addition of subcellular cofactors is required for dementia, Internat J Geriatr Psychiatry, 2018;33:e14-e21.Fessel WJ, Alzheimer's disease may require combination treatment, Neurobiology of Aging, 2017;Nov 8.Fessel WJ, Imbalance between multiple factors, none having sole importance, instigates Alzheimers disease. (Presented at the Alzheimer Association International Conference, Toronto, Canada, July 24-29, 2016).Fessel WJ, Alzheimers Disease. Combination treatment for the mitochondriopathy. (Presented at the Alzheimer Association International Conference, Toronto, Canada, July 24-29, 2016).

Speaker
Jeffrey Fessel University of California
San Francisco, USA

Abstract

Will be updated soon...

Biography

Dr Nabhit Kapur is a Psychology expert, social sector entrepreneur, pioneer, professional mentor and a global champion of positive mental health and well-being among all sections of society. Despite his humble beginnings, he has pioneered and successfully directed mainstreaming mental health as an acceptable, addressable and a real form of ailment for humanity. At a young age of 28, he founded Peacful Mind Foundation, to empower individuals to take charge of their own wellness and to make Psychology a household term. Since then, his efforts have impacted the lives of millions across more than two dozen countries from various strata of society including pilots, army officers, policemen, teachers, students, mothers and young professionals. He has been granted recognition as Chairperson of Global Psychology and Language Research Association and Ambassador-at-Large, Spokesperson (Mental Health) for the United Refugee Green Council as well as Global Ambassador of Healthcare, Canada. He also holds a World Record for his efforts towards revolutionising Psychology and making it a household term in over two dozen countries in a short span of 1 year 6 months. He has also lectured on prestigious platforms like TEDx. His recognitions from across the globe makes him one of the most authentic psychologists to which people can rely. Titles like Ratan e Hindustan, Most enterprising psychologist etc. proves an example for the same.He has been awarded for more than 40 times in 2 years worldwide. Dr Kapur is a visionary and a true thought leader, whose devotion and hard work have ushered new ways of Psychological well-being across nations, age-groups, ethnicities and cultures. From young children to policymakers across the globe, he continues to strive to make human minds perceive and acknowledge the importance of psychological wellness as an imperative for better day-to-day living

Speaker
Nabhit Kapur Founder of Peacful Mind
India

Abstract

Introduction and description: Heritage and trends in the countries of South East Europe have led to defeating facts. These facts are: inadequate and unprofessional care, inadequate living conditions, solitary or lonely life, life without diagnosis and therapy. The society awareness about dementia is at a low level, and dementia is followed by a great stigma. Families seek help when a person with dementia is in late stage III or even stage IV of disease. Then is difficult to nurture or to live with a person with dementia. Goals: Representation the ways and opportunities of good care with representation of good practice in pictures. How to help the affected person and family and improve the condition of the affected person? Is it possible to rehabilitate such a person at all? Can the process be brought back and slow the progression of the disease? Conclusion: Rehabilitation program for people with dementia gives answers to these questions and through this presentation we will present some positive examples of rehabilitation.

Biography

Will be updated soon...

Speaker
Osman Kučuk Director of center for dementia
Bosnia and Herzegovina

Sessions:

Abstract

The calorie sensitive gene Sirtuin 1 (Sirt 1) determines nitric oxide (NO) homeostasis and immunosenescence relevant to the induction of various chronic diseases in human and other species. Appetite control is essential to Sirt 1 function for preventing adipose tissue transformation (adipocytokine release), non alcoholic fatty liver disease (NAFLD) and the development of epilepsy. The global antimicrobial and epileptic drug market is expected to cost 80 billion dollars by the year 2020 with the critical role of Sirt 1 in the maintenance of immunocompetence. Sirt 1 repression by bacterial lipopolysaccharides (LPS) leads to delayed hepatic clearance of anti-microbial drugs with relevance to mitophagy, neuron apoptosis and interference with antimicrobial/antiepileptic drug therapy. Increased absorption of LPS from food/water induces magnesium deficiency with inactivation of antimicrobial/antiepileptic drug therapy. Heat and cold stress alters Sirt 1s role in cell cholesterol dyshomeostasis associated with increased heat shock proteins (HSP) involved with inactivation of antimicrobial proteins such as amyloid beta and promotion of the cytotoxic immune response.

Biography

Ian Martins is a Reveiwer for international journals. Chief Editor for International Journal of Diabetes Research (2014-2017), Research and Reviews: Neuroscience (2016-2017), Journal of Diabetes and Clinical Studies. BIT Member (BIT Congress. Inc) with H-index of 43, (ResearchGate STATs (23), Mendeley STATS (20). Scientist for Science Advisory Board (USA)/Academic with Academia.edu. Citations > 3000. ResearchGates analysis available on google, Tweet, Facebook, Lindekin under Ian James Martins name > 96% of the international SCIENTISTS. Lifetime Membership by International Agency for Standards and Ratings as Fellow for Diabetes, Medical Science (Nutrition). Conferred with the RICHARD KUHN RESEARCH AWARD-2015 ENDOCRINOLOGY AND METABOLISM

Speaker
Ian Martins Edith Cowan University
Australia

Abstract

We report the use of random walk theory (DRW) to assess autism spectrum disorder (ASD) and Rett syndrome. The ASD is not a degenerative disorder, characterized by brain disorders that influence the communication skills and social interaction: deficiencies in verbal and non-verbal communication; the development; the maintenance and understanding of relationships. The detriment of communication skills and social interaction are accompanied by the restriction of interests in a particular topic, activity, academic interest, etc., and may present repetitive patterns of behavior. All of these restrictions are aspects that are part of the spectrum of symptoms which identify individuals with ASD in routine neurological exams. Another disorder that promotes neurodevelopmental damage - Rett syndrome, has a genetic cause qualified by mutations in the MECP2 gene, located on the X chromosome. Rett syndrome consists of the fact that the mutation in the MECP2 gene encodes a defective protein - it does not have the capacity to exercise its biological function adequately. Consequently, genes that should remain inactive during specific phases of neuronal development are conveyed to the active state, resulting in impairments in the development of the central nervous system. From the perspective of the development of new diagnostic tools, we report the use of discrete random walks (DRW) as a diagnostic mechanism for degenerative disorders that characterize autism and Rett syndrome. These disorders are analyzed in two different contexts. In the first context, for autism, we aim to use DRW for the analysis of social behavior, when it has restricted interests or not, with impact on the diffusive regimes, characterizing the different levels of autism. To analyze the Rett syndrome, we used a different context, we sought to understand the mechanisms of translation of defective proteins, indirectly, by means of discreet random walks. We chose mRNA sequences related to Rett syndrome and used them to characterize the dynamics of random walks, besides obtaining measurements of physical observables, analyzed in the representation of the Shannon entropy.

Biography

Thiago Rafael da Silva Moura holds a PhD in Physics from the Federal University of Rio Grande do Norte. He is currently a professor of physics at the Federal University of Para (UFPA) in Salinopolis-PA. He is a Research Associate at the Laboratory of Interdisciplinary Innovation - LabX, Federal University of Para. He carries out research on the following topics: electronic transport in DNA / RNA, magnetic systems, epidemic processes, random walks and non-Markovian processes.

Speaker
Thiago Rafael da Silva Moura Federal University of Para
Brazil

Abstract

Acute subdural haematoma is the most lethal condition among the traumatic brain injury patients. Associated with more severe generalized brain injury, these often occur with cerebral contusions. ASDH are seen in 10-20% of all TBI cases and occur in upto 30% of fatal injuries. Mortality ranges from 50-90% if not operated in indicated cases. Favourable outcomes are expected in patients with GCS score 5 and above, reactive pupils, young adults and time-honoured intervention. Bangladesh is a very densely populated area having 170 million people. We, about 150 Neurosurgeons serve this whole population. A major share of our daily workload is to manage TBI patients. 96 cases of acute subdural haematoma patients were surgically treated in Medical College Hospital (Government) and other private hospitals in Chittagong from January 2009 to December 2016. Male were 70 (73%) while female were 26 (27%). The age incidence ranges from 20 years to extreme ages. Morbidity and mortality were assessed using GCS and GOS scales. 28 (29%) out of 96 patients died postoperatively. Internists and physiatrist were parts of our management team.

Biography

Anisul Islam Khan is graduated from Rangpur Medical College, Bangladesh in 1986. During Under graduate period he was the Founder President of Shandhani of his college as a voluntary Blood and Eye donation organization run by the medical students. After compulsory 2yrs duty in rural area he was posted as a lecturer of Anatomy at Chittagong Medical College, then he was posted as Assistant Registrar and Registrar in the Department of Neurosurgery in Chittagong Medical College and Hospital. After completion of his MS in Neurosurgery in 2009, Now he is working as Associate Professor till date. He presented scientific papers in many national and international conferences and took part in a good number of workshops. He was the past member of executive committee of Bangladesh Society of Neurosurgeons.

Speaker
Anisul Islam Khan Chittagong Medical College Hospital
Bangladesh

Abstract

Alzheimer disease (AD) and Alzheimer disease-related dementias (ADRD) are the major causes of disability and dependency among older people worldwide. Despite extensive research, the molecular mechanism underlying the development and progression of the AD/ADRD in aged population is poorly understood. CDKN1A interacting zinc finger protein 1 (CIZ1), a nuclear protein, plays a critical role in DNA replication and cell-cycle progression at the G1/S checkpoint. Recently, we have reported that germline knock-out of Ciz1 in mice is associated with behavioral, and hematological abnormalities in young adult mice. However, it remains unknown whether CIZ1 deficiency is involved in age-related neurodegenerative disease, particularly in AD. Mouse embryonic fibroblasts from Ciz1-/- mice showed abnormal sensitivity to the effects of γ-irradiation with persistent DNA breaks, aberrant cell-cycle progression, and apoptosis. Aged (18-mo-old) Ciz1-/- mice exhibited marked deficits in motor and cognitive functioning, and, in brain tissues, overt DNA damage, NF-κB upregulation, oxidative stress, vascular dysfunction, inflammation, and cell death. These findings indicate that the deleterious effects of CIZ1 deficiency become more pronounced with aging and suggest that defects of cell-cycle control and associated DNA repair pathways in post-mitotic neurons could contribute to global neurological decline in elderly human populations. Accordingly, the G1/S cell-cycle checkpoint and associated DNA repair pathways may be targets for the prevention and treatment of age-related neurodegenerative processes.

Biography

Khan is a Staff Scientist in the Department of Neurology at University of Tennessee Health Science Center, Memphis USA. Over the past 10 years, Dr. Khan is working on regulation and resolution of neuroinflammation and neurodegeneration in broad spectrum of human neurodegenerative diseases. Dr. Khan has published more than 45 research articles in preclinical CNS models. His research work has been recognized both at national and international levels and has received over 2,000 citation scores with h-index 27 by other scientists. Dr. Khans works has been highlighted by Editorial commentary and captured by several electronic media. Dr. Khan been served as Academic Editor for several manuscripts submitted for the peer review process. He is an active member for several professional societies related to neuroscience and officially review the manuscripts, case reports, and Data sheet for several journals of high impact and international repute. He has been enlisted as Lead editor and editorial board member of many journals in his field.

Speaker
Mohammad Moshahid Khan University of Tennessee Health Science Center
USA

Abstract

This preliminary study has examined ways in which social media may help cause stalker murder by individuals with personality disorders and a strong sense of sexual propriety. A public display on social media by the intended victim was felt to be a trigger that instigated interpersonal violence. To identify behavioural paradigms, case studies of intimate partner murders were explored using news media sources and documentaries. In all of the case studies social media interaction and social media postings occurred shortly before the murder. The evidence suggested a preponderance of correlations between the social media postings, stalking behaviours, personality disorders, and the murder of an intimate partner. In addition to this, a profile for of Facebook/social media murder was gleaned from the paradigms of behavior found in the case studies. The evidence showed a complex relationship between severe violence, stalking, borderline personality, and intimate partner violence was identified through the study. The struggle clients have in dealing with the: public, ambiguous and unrelenting nature of social media postings was also observed. The murderers anguish and rage appeared to be further intensified by attitudes of sexual propriety and entitlement. These attitudes were evident in all the case studies. The study concluded with further research on how the public can protect themselves from entering situations where social media postings might trigger a violent response. Further to this, psychological approaches were identified that might support clients with personality disorders to cope with perceived provocative and distressing data on the internet. Thus, the findings of this study will be of interest to: therapists, psychologists, nurses, criminologists and social workers.

Biography

Will be update soon

Speaker
Amanda Maitland Eisner Institute for Professional Studies
China

Abstract

Although suicide cases are subjected to underreporting in Lebanon, it is apparent from available statistics, that suicide is a public health issue in Lebanon. Data from the Internal Security Forces show that 1 person dies of suicide every 3 days and 1 person attempts suicide every 6 hours. In response, Embrace, a Lebanese NGO and mental health awareness network, has established the first national suicide prevention and emotional support helpline, Embrace Lifeline. Embraces helpline provides over-the-phone emotional support and referrals to necessary community resources and treatment programs. Methods: The helpline was established in 2017, within a framework of a non-interventionist approach, under the guidance of the Centre for Research and Intervention for Suicide and Euthanasia in Canada (CRISE). Results: Phase I of the helpline establishment, consisted of planning and partnering with key-stakeholders in Lebanon and worldwide. Phase II focused on training telephone operators and trainers in Suicide Risk Assessment and Crisis Intervention, and establishing structured protocol to evaluate suicide risk, develop hope, engage the caller in collaborative problem solving, and refer to appropriate community resources when needed. Phase III, in September 2017, saw the soft launch of the helpline, operating from 12 pm till 2 am, and receiving a total of 50 calls. Preliminary data was used to improve services, and develop electronic data-capturing plan. We expect to launch Phase III in January 2018. Social and clinical implications will be discussed.

Biography

Mia Atoui holds a Master degree in clinical psychology and a Master degree in public health from the American University of Beirut (AUB). As a psychologist who is continuously engaged in patient care, Mia has always appreciated the need to practice psychology not only in the private setting of the clinic and hospital, but also to be immersed in the community and bring direly needed psychological services into the community. Founding Embrace has been an opportunity to reach out to the community, spread awareness where it is needed, and allow others who are in need to reach out to us as well.

Speaker
Mia Atoui Co Founder and Board member of Embrance
Lebanon

Abstract

The article discusses the hypothesis of possibility of a model for prognosticating a text based on the field of emergence. It is assumed that on the base of a communicative situation there caused a field of emergence, which denotes the boundary of structural and semantic models, prognosticated as verbal forms of the communicative situation. The cause of the field of emergence is observed in the analysis of different translations of the same text, because any text that should be interpreted verbally can be assumed as a model of the communicative situation. The main task, which is placed in the article, is an attempt to determine a fuzzy model, which is capable in maximal degree of probability to calculate the volume of linguistic fuzzy sets potentially useful as language material for a communicative situation within the field of emergence.

Biography

1988-1993 - Department of Romano-Germanic Philology of the Chechen-Ingush State University, specializing in Teaching English and French. Qualification by diploma is "Philologist, Teacher of English and French". 2009 - defense of the thesis for the degree of Candidate of Philology on the topic: "Emergence as a component of invariantly-variable structures of translated texts" (10.02.19). Work experience: 1993-2003. - Worked in different organizations. 2003-2006 - Assistant Professor of General Linguistics chair philology department of Chechen State University. 2006-2009 - Senior Lecturer of General Linguistics chair, 2009-2015. - Associate Professor of the of General Linguistics chair. From 2015 to present day - Dean of the Foreign Languages department of Chechen State University.

Speaker
Albekov Nurvadi Chechen State University
Russian Federation

Abstract

Tau protein plays a crucial role in many neurodegenerative diseases including Alzheimer's disease (AD). Tau inclusions and amyloid beta (AB) deposition have been described in the post-mortem retina exams of AD patients. Cryo- electron microscopy ( Cryo- EM ) was recently used to detect the detailed structure of Tau filaments. Methods and Result : We examined the retinas of PET-proven live AD patients by spectral domain optical scanning tomography ( SD- OCT ) and fundus autofluorescein ( FAF ). The hyper or hypo- fluorescent lesions in the retina were scanned by OCT and images that completely corresponded with the histopathological and Cryo- EM shapes of Tau filaments were observed. Conclusion : Retinal Tau is a very promising target to detect early changes in AD and retinal imaging may be an exciting and trustable technique to predict and monitor the disease.

Biography

Umur Kayabasi is a graduate of Istanbul Medical Faculty. After working as an assistant in Ophthalmology, he completed his clinical fellowship program of Neuro- ophthalmology and electrophysiology at Michigan StateUniversity in 1995. After working as a consultant neuro- ophthalmologist in Istanbul, he worked at Wills Eye Hospital for 3 months as an observer. He has been working at World Eye Hospital since 2000. He has chapters in different neuro- ophthalmology books, arranged international symposiums, attended TV programs to advertise the neuro- ophthalmology subspecialty. He has also given lectures at local and international meetings, plus published papers in neuro ophthalmology

Speaker
Umur Kayabasi Uskudar University
Turkey

Sessions:

Abstract

The present study explored the relationship overcoming destructive beliefs with the use of Rational Emotive Behavior Therapy among HIV patients. It was hypothesized that there is likely to be relationship between rational emotive behavior therapy to challenge the destructive beliefs among HIV patients. Repeated measure research design was employed and purposive sampling was used to draw a sample of 12 patients who had undergone treatment for HIV disease from Mayo hospital, Jinnah hospital and Services Hospital, Lahore. Demographic information sheet, history take examination, MSE and destructive beliefs measure by shortened general attitude and belief scale. The new and personal invention of the study is the pictorial presentation of REBT techniques give a better understanding and significant result. All the pictures were hand made and my mind invention. The finding of the study indicated a significant difference in irrational beliefs of HIV Patients before and after treatment. Based on the finding, it can be concluded that present research provides justification for irrational beliefs in HIV Patients.

Biography

Adeela Saba did M.S.C from B.Z.U, A.D.C.P from Sargodha University and NLP, Hypnosis from G.C university. She won three time best international research awards from OMICS and conference series research center 2015 and 2017 on the behalf of her research related to drug users and HIV patients. She also won two times Gold Model awards for her excellence performance in Global rehab center and AL-Fatah Clinic. She also the member of (APA) American psychological association. Now a days she is doing practice in ALFATHA clinic and Government Services Hospital in Pediatric Department and treat the HIV and AIDS Patients.

Speaker
Adeela Saba Clinical Psychologist & Consultant BCC in Services Hospital
Lahore, Pakisthan

Abstract

Alzheimer's disease (AD) is an incurable age-associated neurodegenerative disorder that is characterized by irreversible progressive cognitive deficits and extensive brain damage. The identification of candidate biomarkers before beta amyloid plaque deposition occurs is therefore of great importance for the early intervention of AD. Urine, which is not regulated by homeostatic mechanisms, theoretically accumulates changes associated with AD earlier than cerebrospinal fluid and blood. In this study, an APP (swe)/PSEN1dE9 transgenic mouse model was used to identify candidate biomarkers for early AD. Urine samples were collected from 4, 6, and 8 month old transgenic mouse models, and the urinary proteomes were profiled using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). The levels of 33 proteins differed significantly between wild type and 4-month old mice, which had not started to deposit beta amyloid plaque. Among these proteins, 16 have been associated with the mechanisms of AD, while 9 have been suggested as AD biomarkers. Our results indicated that urine proteins enable detecting AD before beta amyloid plaque deposition, which may present an opportunity for intervention.

Biography

Youhe Gao Professor Beijing Normal University. He received his MD from Peking Union Medical College, his Ph.D from University of Connecticut and postdoctoral training from Beth Israel Deaconess Medical Center, Harvard Medical School. He was the professor of Department of Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/ Peking Union Medical College from 2001-2014. His research interests include biomarker discovery in urine, urine biobanking, protein interaction methods and related bioinformatics.

Speaker
Youhe Gao Beijing Normal University
China

Abstract

In the Alzheimer Perales Association, we have started a work project with Alzheimer's patients and other dementias in August of this year 2017. After the first testing period, we have our team ready with The HTC Vive Virtual Reality Glasses. We are working on adapting users to this new equipment. For the moment, we are using the programs already created: Google Earth, Tilt Brush, or The Blue. In February, with phase I of the study of the effects of the Virtual Reality test on the real orientation in the street. Previously, women with a diagnosis of Alzheimer's disease have been selected, a score according to Folstein's Minimental Scale was taken as an indicator of the degree of cognitive deterioration, a score on the Hamilton Depression Scale and a level of deterioration of GDS. The Global Deterioration Scale for Assessment of Primary Degenerative Dementia The Global Deterioration Scale (GDS), developed by Dr. Barry Reisberg, provides caregivers an overview of the stages of cognitive function for those suffering from a primary degenerative dementia such as Alzheimer's disease. The first step will be the journey of the patient down a little known street to him, to a place where he goes daily, about 3 minutes. Your behavior will be recorded on video during the course, it will be necessary to intervene if you are exposed to any danger. Then we will proceed to the recording with the 360 degree camera that same route. For 8 weeks the user will make the journey as an essay with the Virtual Reality glasses, with a frequency of 2 times per week. The written record of the essays will be taken, in addition to the video recording of them. The ninth week will return to the same route with the user, in the same way as the first time, without any assistance, except in case totally necessary - if the user is put in some unsafe situation - and will return to register with the video. We will proceed with the trial with 2 women diagnosed with neurocognitive disorder due to Alzheimer's disease. A woman with the same diagnosis will act as a control person since she will go through all the conditions of the study, but without receiving the training with the glasses of that specific route. We know the limitations of the study, very few subjects, it agrees that they are only women and that we do not have experience with these concrete tests through Virtual Reality. We expect next year 2019 to make a second phase much more powerful and with a larger sample.

Biography

In the Alzheimer Perales Association, we have started a work project with Alzheimer's patients and other dementias in August of this year 2017. After the first testing period, we have our team ready with The HTC Vive Virtual Reality Glasses. We are working on adapting users to this new equipment. For the moment, we are using the programs already created: Google Earth, Tilt Brush, or The Blue. In February, with phase I of the study of the effects of the Virtual Reality test on the real orientation in the street. Previously, women with a diagnosis of Alzheimer's disease have been selected, a score according to Folstein's Minimental Scale was taken as an indicator of the degree of cognitive deterioration, a score on the Hamilton Depression Scale and a level of deterioration of GDS. The Global Deterioration Scale for Assessment of Primary Degenerative Dementia The Global Deterioration Scale (GDS), developed by Dr. Barry Reisberg, provides caregivers an overview of the stages of cognitive function for those suffering from a primary degenerative dementia such as Alzheimer's disease. The first step will be the journey of the patient down a little known street to him, to a place where he goes daily, about 3 minutes. Your behavior will be recorded on video during the course, it will be necessary to intervene if you are exposed to any danger. Then we will proceed to the recording with the 360 degree camera that same route. For 8 weeks the user will make the journey as an essay with the Virtual Reality glasses, with a frequency of 2 times per week. The written record of the essays will be taken, in addition to the video recording of them. The ninth week will return to the same route with the user, in the same way as the first time, without any assistance, except in case totally necessary - if the user is put in some unsafe situation - and will return to register with the video. We will proceed with the trial with 2 women diagnosed with neurocognitive disorder due to Alzheimer's disease. A woman with the same diagnosis will act as a control person since she will go through all the conditions of the study, but without receiving the training with the glasses of that specific route. We know the limitations of the study, very few subjects, it agrees that they are only women and that we do not have experience with these concrete tests through Virtual Reality. We expect next year 2019 to make a second phase much more powerful and with a larger sample.

Speaker
Ana Maria Perales Blasco president of the Alzheimer Perales Association
Spain

Abstract

Demyelination affects highly myelinated structures like Corpus Callosum (CC). CC is unique in function that it connects right and left hemisphere. It synchronises bimanual or bipedal activities. Affecting CC can disturb synchrony between the two hemispheres will affect bimanual and bipedal tasks. The aim is to see if speed of clapping (bimanual activity) can reflect the involvement of CC in Multiple Sclerosis. Consecutive 70 Multiple Sclerosis patients from Outpatient clinics and Home visits were tests for bimanual hand function (clapping) Exclusion criteria are upper limb power <3/5 MRC scale, Pain, Visual impairment, Intentional tremors, Stroke or Cognitive impairment. Study period started from 01 09 2016. Comparison of speed between rapid supination/pronation of left and right hand separately and then clapping of both hands (supination/pronation of each hands alternatively). Patients had to do as fast as they could. Noticeable slowing of clapping comparing to single hand supination/pronation was taken as a sign slowing down of conduction through CC. 31 patients were excluded, 34 patients showed no noticeable difference, 2 patients were difficult to make conclusions and 3 patients showed definite slowing down in clapping. Positive patients will have difficulties in doing bimanual activities like using two sticks for mobility, typing using keyboard, pushing wheel chair bimanually etc. etc.. It is possible to detect CC involvement by doing above bedside test and can be used in Rehabilitation Setting. Sample size is not large enough and larger studies need to follow to validate the finding.

Biography

Dr. Khin Bo is involved in NeuroRehabilitation over 20 years. He is also a Lecturer (Hon) in Hull and York Medical School teaching 4th Year Medical Students in CNS and Musculoskeletal Blocks. He is doing Botulinum Toxin injection in Spasticity, Dystonia and Involuntary Movement disorders over 15 years and done Poster presentations and Oral Presentations in International NeuroRehabilitation Conferences. He is also involved in using Functional Electrical Stimulation (FES) over 10 years and presented regularly in International FES Conferences. He is working on developing Hypertonic Hand Monitoring Scale. He recently Published another Bedside Test In Neurology (Finger Nose Proprioception Test).

Speaker
Khin Bo North Lincolnshire & Goole NHS Foundation Trust
United Kingdom

Abstract

The present study explored the effectiveness the Rational Emotive Behavior Therapy in disputing the irrational beliefs persons with substance use disorder. It was hypothesized that there is likely a negative relationship between rational emotive behavior therapy exposures and the irrational beliefs in person with substance use disorder. Repeated measure research design was employed. Purposive sampling was used to draw a sample of 12 patients who had undergone treatment for substance use disorder from addiction ward. PIMH and Fountain House, Lahore (Demographic information sheet, history take examination), and MSE were used to rule out others psychiatric illness. After the careful examination, diagnosis of the substance disorder’s irrational beliefs was measured by shortened general attitude and belief scale. The new and personal invention of the study is that pictorial presentation of REBT techniques gives a better understanding and significant result. All the pictures were hand made and mind invention. The present study was able to find out the effectiveness of REBT in disputing irrational beliefs in substance use disorder. The finding of the study indicated a significant difference in irrational beliefs of persons with the substance use disorder before and after the treatment. Based on the finding, it can be concluded that present research provides justification for irrational beliefs in persons with the substance use disorder.

Biography

Adeela Saba did M.S.C from B.Z.U, A.D.C.P from Sargodha University and NLP, Hypnosis from G.C university. She won three time best international research awards from OMICS and conference series research center 2015 and 2017 on the behalf of her research related to drug users and HIV patients. She also won two times Gold Model awards for her excellence performance in Global rehab center and AL-Fatah Clinic. She also the member of (APA) American psychological association. Now a days she is doing practice in ALFATHA clinic and Government Services Hospital in Pediatric Department and treat the HIV and AIDS Patients.

Speaker
Adeela Saba Clinical Psychologist & Consultant BCC in Services Hospital
Lahore, Pakisthan

Abstract

A decline in the ability to process facial expression of emotions has been reported in individuals with Alzheimer’s disease (AD). However, the low number of participants and the lack of diversity in the tasks being used in previous studies leaves a gap in our knowledge about this issue. gap, wWe recruited 169 participants including healthy older adults (HOA), participants with mild cognitive impairment (MCI) and AD patients at different stages of the disease (mild to moderate). Four tasks including recognition, selection, matching and declarative knowledge about facial expression of emotions were used. Face identification was used as a control task. Our results revealed that compared with HOA, MCI participants did not show any significant deficits in none of the tasks. AD patients did not show any impairment in the control task. However, they were impaired in the processing of facial expression of negative emotions across all four affective tasks. Interestingly, recognition and selection of happiness were intact in AD patients at the mild stage of the disease. Our findings suggest that despite the pathology affecting distributed areas in the brain, the less challenging aspects (recognition and selection) of the ability to process the facial expression of happiness were preserved at the early stage of the disease. By recruiting a large number of participants together with several different tasks our study provides a comprehensive picture of the disorders of facial emotion processing in Alzheimer's Disease. Our findings have significant implications for improving the AD patients’ quality of life and the quality of their social interaction with others. Future studies might start to investigate the processing of emotions in AD patients in other modalities rather than visual.

Biography

Will be updated soon...

Speaker
Zahra Moradi University of Oxford
United kingdom

Abstract

This talk will discuss the premise that older African-Americans with anhedonia (reduced ability to experience pleasure) may be particularly susceptible to faster cognitive decline. We will present on a study designed to investigate whether older African-Americans can be trained to up-regulate empathic happiness (i.e. vicarious happiness) as a means to reduce anhedonia measurable with functional magnetic resonance imaging (fMRI). Thus, the brain correlates of empathy subtypes will be investigated using fMRI in a sample of predominantly African-American psychiatric and neurological patients (including Treatment Resistant depressed/preclinical dementia, schizophrenic/schizoaffective, demented, Parkinsons disease) who are also clinically anhedonic—using a previously validated empathy induction paradigm. Specifically, empathic happiness, will be elicited in this patient sample versus age- and premorbid IQ matched healthy controls (and a non-anhedonic neurological control group made up of patients diagnosed with multiple sclerosis), by having each participant watch video clips extracted from the television show Extreme Makeover: Home Edition while fMRI data is recorded. Participants will watch passively and be instructed to up-regulate empathy at different times. The neural signature of empathic happiness has already been elucidated in a previous fMRI pilot study utilizing healthy adults; our aim here will be to investigate whether patients with psychiatric/neurological disorder and anhedonia show deficits in fronto-striatal reward circuitry previously shown to be active when healthy adults empathize with the positive emotion of another. It is expected that the frontostriatal network will show diminished activity across the anhedonic patient group compared to the healthy control group/non anhedonic neurological group during the passive condition, and this will be mediated by reduced nucleus accumbens/globus pallidus & prefrontal cortex, and insula activity; based on these regions known association with typically developed vicarious positive affect. It is expected that this reduced frontostriatal activation pattern will map onto the patients (1) self reported, and (2) task based anhedonia scores. The purpose of this study is to determine whether patients can overcome these deficits in the up regulate condition, after being trained to up-regulate empathic happiness which if successful, may help alter disease trajectory in this high-risk group.

Biography

Dr. Sharee Light completed her PhD from University of Wisconsin-Madison, USA and her postdoctoral studies from the University of Michigan Medical School, USA. She is currently the director of the Positive Affective Neuroscience Laboratory. She has published peer-reviewed papers in reputed journals such as the Proceedings of the National Academy of Sciences and Biological Psychiatry.

Speaker
Sharee Light Georgia State University
United States

Will be updated soon...


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