Polymers for Cellular Control
Dr.Mark did his PhD at the University of Oxford, followed by post-doctorial studies at Harvard Medical School before being appointed a Royal Society University Research Fellowship. He was awarded a Professorship in Combinatorial Chemistry in 1996 aged 34. He has been elected to fellowships of the Royal Society of Chemistry and Edinburgh, and awarded a number of prizes including the Novartis Lectureship and the 2015 RSC Tilden Prize. He has published >350 peer reviewed papers, filed some 25 patents and is co-founder of Ilika Technologies (IPO 2010) and Edinburgh Molecular Imaging. Mark is director of Proteus an Interdisciplinary Research Collaboration supported by major investment from the EPSRC (£11.3M) and the three partner universities (£3M) (20 post-docs and 20- PhD’s). Interdisciplinary is at the heart of Proteus - linking together disciplines such as optical physics, chemistry, biology and engineering. He holds an ERC Advanced grant in the area of polymer chemistry.
Manufacturing a New Generation of Biomaterials for Healthcare
Professor Mohan Edirisinghe FREng holds the established Bonfield Chair of Biomaterials in the Department of Mechanical Engineering at University College London (UCL) and has served as a University of London professor for over 20 years. He was appointed to this UCL chair in December 2005 and prior to this he was Professor of Materials at Queen Mary University of London. He has actively pursued advanced materials processing, forming and manufacturing research, for over 25 years publishing over 450 journal papers with a H-index of 61 and over 12000 citations. In addition, his research has led to many inventions and patents and he has also delivered over a 100 keynote/invited lectures at many different international conferences and meetings worldwide, particularly in the USA (major recent meetings include: TMS, MS&T and MRS). He has supervised over 200 researchers, graduating 100 doctoral students (36 to date at UCL), and has been awarded grants to the value of over £25 million, with 43 UK Research Council grants including two Platform Grants which have given him the opportunity to adventurously explore novel avenues of forming and manufacture of advanced materials for application in key areas such as healthcare. His research has won many prizes including the Royal Society Brian Mercer (Innovation) Feasibility Award an unprecedented three times (2005, 2009 and 2013), the 2010 Materials Science Venture Prize and the 2012 Presidents Prize of the UK Biomaterials Society to recognise outstanding contributions to the biomaterials field. In 2017 he was the recipient of The Royal Academy of Engineering Armourers & Brasiers prize for excellence in Materials Engineering and the Premier IOM3 Chapman Medal for his distinguished research in the field of biomedical materials.
All-In-One Targeted Solutions for Biomedical Imaging and Therapy- Nanotechnological Approach
Dr. Jayasree is a senior scientist in Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala and heads the Division of Biophotonics and Imaging. She completed her Post graduation from CUSAT and PhD from Kerala University in Physics. She is a leading scientist with interest focused on the applications of Nanotechnology in the healthcare field. Specific areas include Biomaterials for imaging and therapy, spectroscopic techniques, nanophotonics and nanobiophotonics applied to health care field. Other than nano science, she also has high passion towards developing new methods of research and translate to clinics; like laser treatment for disc prolapse, osteoid osteoma, esophageal and bronchial tumor and varicose vein. Therapeutic aspects also include drug delivery, photodynamic therapy, photothermal therapy, hyperthermia etc. She also has exemplified flair in the design of biomaterials with desired properties for crossing BBB, drug delivery, cancer therapy and sensing. She is a fellow of Royal Society of Chemistry, London and Fellow of Academy of Sciences, Chennai. She is the recipient of MRSI Medal in 2017. She has also received PSN National Award for excellent R&D in rural technology in 2011, Endeavour Research Fellowship by the Australian Government, 2009 and was nominated as Australia Award Ambassador by the Australian High Commissioner to India during 2012 to 2015. She has more than 80 publications and 5 patents in the field of spectroscopy, material science and nanoscience.
Innovative Biomaterials for Orthopedic Tissue Disorders
Prof. Krishna Pramanik is Professor in the department of Biotechnology & Medical Engineering. Her research interests are Nanobiotechnology/Nano medicine, Fermentation, Bioprocess Engineering, Biomaterial & Tissue Engineering,Reaction Engineerin,Bio energy Modeling & Simulation of Biological Reactions,Environmental Biotechnology.Working at National Institute of Technology, Rourkela as Professor since July 2007.
Novel synthetic approaches to Innovative BioEngineering
Dr. Hala Zreiqat is a professor of biomedical engineering at the University of Sydney and both a National Health and Medical Research Council Senior Research Fellow (2016-2020); Director of the Australian Research Training Centre for Innovative Bio-Engineering; Co-Director of the Shanghai-Sydney Joint Bioengineering and Regenerative Medicine Lab at Shanghai JiaoTong; Honorary Professor Shanghai Jiao Tong University and Adjunct Professor Drexel University. She is the 2018 New South Wales Premier’s Woman of the Year. The King Abdullah II Order of Distinction of the Second Class - the highest civilian honour bestowed by the King of Jordan (2018). Her research is on the development of novel engineered materials and 3D-printed platforms for regenerative medicine, particularly in orthopaedic, dental, and maxillofacial applications. She has established national and international industry collaborations to translate her discoveries into approved medical devices. Her pioneering development of innovative biomaterials for tissue regeneration has led to one awarded (US) and 7 provisional patents, and several collaborations with inter/national industry partners. She has been awarded more than $17 M in competitive funding including from the NHMRC, ARC and the NSW Medical Devices Fund. She is the past president of the Australian & New Zealand Orthopaedic Research Society.
Effects of Nanoparticle Core on Cellular Activities Under the Controlled Shape, Size, and Surface Chemistries
Dr.Bing Yan got his Ph.D. from Columbia University in 1990 and carried out postdoctoral research at University of Cambridge, U.K. and University of Texas Medical School in Houston from 1990 to 1993. From 1993 to 2005, he was working on drug discovery research at Novartis, Discovery Partners International, and Bristol-Myers Squibb. He was a Full Professor and Director of High-Throughput Analytical Chemistry Center at Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital in Memphis, Tennessee from 2007 to 2012 and Changjiang Scholar Professor at Shandong University, Jinan, China since 2005. He served as Co-Editor-in-Chief for “Ecotoxicology and Environmental Safety” and Associate Editor for “NanoImpact” both published by Elsevier. He has published 11 books and more than 230 peer-reviewed papers
Enhanced Biodegradability of an Fe-Mn Alloy using a Microstructural Approach and by Modifying the Surface with Laser Ablation
Dr. Matjaž Godec has completed his Ph.D at University of Ljubljana, Slovenia, at Faculty of Natural Science and Engineering, Metallurgy in 1997. Since 2011 he has been a director of Institute of Metals and Technology in Ljubljana Slovenia. He has published more than 100 original scientific papers in reputed journals and more than 200 reports and expertise for industrial partners. He is also first assistant chief editor of the journal Materials Science and Technology and the main organizer of International Conference on Materials and Technology. Currently, he is a head of European project MARTINA, financed by Structural Funds, which value is around 10 M€ and brings together 16 partners from Slovenia. He is an expert member at the advisory body Steel Advisory Group within the Research Fund for Coal and Steel as the representative of Slovenia, which falls under the umbrella of the European Commission's Directorate general for Research and Innovation.
Advanced Engineering of Hydrogels for Wound Dressing and Healing
Jen Ming Yang is currently a Professor in department of Chemical and Materials Engineering at Chang Gung University, Research Fellow (joint appointment) of Chang Gung Memorial Hospital, Linkou, and Council of Tissue Engineering and Regenerative Medicine International Society-Asia-Pacific Chapter (TERMIS-AP). He has been serving as editorial board members of some journals. He has also presented keynote and invited speeches at many conferences and hosted international conferences.
Scalable and Cleavable Polysaccharide Nano-Carriers for Gene/Drug Co-Delivery
Hongjing Dou grew up in Henan, a province in the central part of China, where she obtained her BSc in Chemistry and M.E. in Polymer materials. She then moved to Shanghai in 2000 to pursue PhD under the supervision of Prof. Ming Jiang at Fudan University. Her work there focused on the synthesis of polysaccharides-based biomacromolecules and their co-assembly with synthetic polymers. After obtaining her PhD in 2003, Hongjing joined Shanghai Jiao Tong University (SJTU) as a lecturer, and was then appointed as an associate professor in 2008 and a professor in 2015. Between 2009 and 2010, Hongjing spent 14 months in Prof. Guojun Liu’s group at Queen’s University in Canada, where she worked on the self-assembly behavior of linear triblockterpolymers. In February of 2015, Hongjing was awarded the Marie-Curie International Incoming Research Fellowship to support her research as a visiting scholar in University of Bristol with the supervision of Profs. Ian Manners and Stephen Mann.
Biomimetic Materials and New Processes to Achieve Porous Scaffolds for Bone Regeneration
Dr.Simone Sprio,Born on 1970. M.Sc. in Physics, Ph.D. in Chemistry, Senior Researcher at the Institute of Science and Technology for Ceramics, National Research Council, ISTEC-CNR. Responsible of the research activity on Bioceramics for Regenerative Medicine at ISTEC-CNR. Main fields of investigation are: Nanomaterials and Nanotechnologies: ceramic-based biomaterials, nanoparticles and 3-D porous scaffolds with cell-instructive properties. Author of >100 peer-reviewed papers and book chapters. Inventor of 9 funded international patents, related to new materials and devices for medicine. More than 100 communications including 20 Invited Lectures at International Conferences. Scientific Responsible or WP Leader in several national and EC-funded projects.
Nature Inspires Smart Materials for Tissue Regeneration
Dr.Anna Tampieri, Chemist, 30 years of experience in Material Science, particularly addressed to biomimetic materials and devices for regeneration of hard and soft tissues and organs. She authored more than 200 scientific papers published on peer-reviewed Journals and about 20 book chapters (H index = 45 based on Scopus). She is inventor of 16 National and International patents, several of which are licensed to companies acting in the biomedical fields and translated to 7 commercial products. She is the tutor of 11 Ph.D, 14 M.Sc students, and more than 20 National and International fellowships. Coordinator of 8 EC-funded Projects belonging to the 6th and the 7th European framework programmes, and WP Leader in 6 EC-funded Projects. Coordinator of several national projects. Since 2009 she is member of the “European Technology Platform for Nanomedicine”. Since 2011 is Senior Affiliate Member at the Methodist Hospital Research Institute, Houston, U.S.A. Associated Professor in Medical Science and Applied Biotecnology, since 2014. Founder of the company FINCERAMICA Biomedical Solution S.p.A, she was the Idea-woman, then President and today is the Head of the Scientific Advisory Board. Awarded by the TIME Magazine for “from Wood to Bone” as the 30° research among the most important 50 researches in 2009. Awarded from Massachusetts Institute of Technology Review for the project GreenBone (biomimetic bone implants).Founder of the Start UP GreenBone Ortho Srl in 2014.
Smart Biomaterials in Health Care Technology
Dr.Hossein Hosseinkhani has broad experience in life sciences and is expert in nanotechnology, biomaterials, drug delivery, 3D in vitro systems, bioreactor technology, and bioengineering stem cells technology. He has long experience in both academia and industry in biomedical engineering research and development, which includes several years of basic science research experience in a number of premier institutions related to the structure and function of biomaterials, and in polymer-based and mineral-based medical implants development in the medical device industry.
Prof. Gianfranco Peluso graduated magna cum laude and special mention in Medicine at the University of Naples, Italy. He has been Director of the Department of Experimental Oncology at the National Cancer Institute. Currently, he is Research Director at Italian National Research Council. His scientific activity and areas of interest include: nanoscience and nanotechnology applied to biomedicine, life science and food security, for: a) development of nanostructured polymers as novel delivery platform to minimize drug degradation upon administration, prevent undesirable side effects, and sustain and/or increase drug's bioavailability in a targeted area, and b) synthesis of biodegradable polymers for innovative food packaging to improve shelf life, microbiological safety and sensory properties of foods without affecting their organoleptic and nutritional characteristics.
Bagasse sustainable polymers for cellulose hydrogels in their properties of tissue regeneration and regenerative medicine
Takaomi Kobayashi has received his PhD in Osaka University, Faculty of Science. (1988). He worked in Nagaoka University of Technology (NUT) as research associate (1991). In 1995, he was visiting researcher in Emory University, USA and then associate professor and professor (2006) in NUT at Department of Materials Science and Technology and also Department of Science and Technology Innovation. Intelligent materials and their chemistry relating with bio-sustainable and environmental science and technology are his research interests. He has published more than 190 papers in reputed journals and serving an editorial book and book chapters.
Cholederm: a porcine cholecyst-derived bioscaffold for wound healing
Dr Thapasimuthu V Anilkumar is a registered veterinarian in India specialized in Pathology, (Diplomate ICVP), Laboratory Animal Medicine (Cert LAM) and Toxicologic Pathology (Fellow, IATP). He works for Sree Chitra Tirunal Institute for Medical Sciences and Technology which is an institution of national importance under the Government of India and an internationally accredited testing facility (ISO17025) for biomaterials and biomedical devices. He holds a PhD of the Imperial College School of Medicine at Hammersmith (1996, University of London) and the research interests include the use of mammalian cholecystic extracellular matrix for tissue engineering and regenerative medical applications.
Customized Biomimetic Dental Implants for Early Bone Regeneration: combined use of nano-diamond modified biodegradable hydrophilic polymeric coatings and 3D sintered Titanium elasto-progressive trabecular structures
Prof. Antonio Apicella has completed his PhD from the Engineering School of the University of Naples, Institute of Engineering Principles, Italy and postdoctoral studies from North Carolina State University and Washingthon University USA, and at the University of Naples, Italy. He is the director of Advanced Materials Lab, a premier Laboratory for studies on nano based hybrid biomaterials. He has published more than 250 papers in reputed journals and has been serving as an editorial board member of repute.
Application of Proteins in Drug Delivery Systems: An Example of Clinical Translation.
Dr. Dawei Ding obtained his master degree in pharmaceutics at Nanjing University in 2011, and his Ph.D. degree in Materials Science and Engineering at Nanyang Technological University in 2016. His research interests are to engineer biocompatible materials and explore their applications in biomaterials and drug delivery systems. He has published 13 scientific papers in the related fields, with some first-authored or co-first-authored ones appeared on Advanced Materials, ACS Nano, and Biomacromolecules.
Dr. Amany Mohamed Abbas work as a researcher in Veterinary serum and vaccine research institute as a quality Assurance Manager, technical manager deputy and head of virology unit in Quality Control Laboratory. Researcher of virology Department till now. Professional experience includes Preparation of tissue culture BHK21 ,VERO, MDBK cell lines and primary cell culture MDCK ,CEF,OS, Preparation and evaluation of attenuated and inactivated bovine viral disease Vaccines, Evaluation of different viral disease vaccines according to international protocols, Evaluation of post vaccinal immune response by using different serologicaltests, preparation of some nano- adjuvants, molecular RT-PCR, Formulating program of training courses in virology and immunology for veterinarians and technicians, training on Principals of Bioinformatics and Biological Data Analysis, ISO 17025: 2005- 2017, ISO 22000 lead auditor, Trained on molecular diagnostic at the Vector and Vector Borne Disease Research Institute, Tanga-Tanzania.
Nanohybrid composite from rice husk reinforced with zirconia:ahistrionic challenge?
Dr. Noor Huda Ismail is a specialist and lecturer at Prosthodontics Unit, School of Dental Sciences, UniversitiSains Malaysia (USM). She started as a Dental Officer at USM following her graduation with Bachelor of Dental Surgery (BDS) at University of Malaya. Then, she became a trainee lecturer before continuing her studies at University of Dundee in prosthodontic and graduated in 2012. She is a member of Malaysian Association of Prosthodontics (MAP). She is also a member of Royal College of Physicians and Surgeons of Glasgow for Introductory Module since in 2013. She has been actively participating in various national and international prosthodontic conferences and had published papers in local and international journals. The field of her main clinical interest and research includes fixed and removable prosthodontics, endodontically treated teeth and dental biomaterials. Currently, she is doing research on nanocomposite reinforced by zirconia and also nanohybrid composite luting cement from rice husk.
Metallic ionenhancingantibacterial activity on titanium implants
Dr. Shinn-Jyh Ding has completed his PhD from Department of Materials Science and Engineering at National Cheng Kung University, Taiwan. He is the director of Institute of Oral Scienceat Chung Shan Medical University, Taiwan. He has published more than 100 papers in peer-reviewed internationaljournals.The research interests include syntheses of bioceramics, development of biomimetic bone grafts for bone repair and regeneration, and surface modification of titanium and zirconia implants.
Comparison between natural and synthetic biomaterials for use in bone surgery.
Dr.Hassane Oudadesse graduated from the Blaise Pascal University of Clermont-Ferrand France. Since 2001, he works in the University of Rennes 1 as Full Professor in the ISCR UMR CNRS 6226. His works concern the conception, synthesis and physicochemical studies of new biomaterials for applications in orthopaedic surgery. He is author of more than 150 papers published in international journals and 70 international conferences. Professor Hassane Oudadesse is a Head of the research unit on Biomaterials since 2001, Vice President of University of Rennes 1, human resources 2008-2012, Director of Master 2 Solid Chemistry and Materials since 2006. He was the President of the Chemical Department from 2002 to 2004 and the President of the specialists commission CNU 33 (Materials Chemistry) 2003- 2008.
Medical Biopolymeric film.
Dr.Jalil K. Ahmed has completed his PhD at the age of 37 years from Baghdagd University and Martin Luther University , Germany . I have over 50 publications and eight patents were registered with 3 books. 2016 reviewer for John Wiley & Sons .2015 a Member of the American Scientific Publishing Group. 2012 My name appeared in the Encyclopedia of Chemistry Scientists . I received the Science Day Award for the years 2009 -- 2012. 2013 I received the Medal of Scholars from the Government of Iraq on my research "Using of chlorophyll as absorbent Gamma radiation to protect the children of Iraq from cancer." 2014, I became a member of the Who is Who Network. 2016, 2017 and 2018 Participated in the QS World University Rankings (QS) for world universities. 2018 Qualified for Marquis Who is Who Award in America. 2018 Received a high honor certificate from the United Nations Commission on Human Rights (OHCHR) for my Bioresearchs in the service of humanity.
Polymer-Free Cyclodextrin Based Nanofibers in Regenerative Medicines.
Dr. Bahijja Raimi-Abraham is a pharmacist and Lecturer in Pharmaceutics at King’s College London where her research group focuses on drug development and molecular pharmaceutics in Ageing and Global Health. Prior to her current position at King’s College London, Dr. Raimi-Abraham held positions at University College London (UCL) as an EPSRC postdoctoral researcher and at the European Medicines Agency (EMA) as a seconded Quality National Expert. Dr. Raimi-Abraham is the first graduate of the University of East Anglia School of Pharmacy to be awarded a Ph.D and more recently won the Outstanding Woman in STEM Precious Award.
Effect of Adding Two Levels of Organic Selenium and Selenium Nanoparticles in the Diet on the Productive Performance of Broiler Chickens Ross 308
Will update soon...
Herbal plant extract based synthesized metal nanoparticle enhances anti-tumorpotential.
Dr.Pramod Kumar Gautam had completed his Ph.D. and Post-Doctoral studies form Banaras Hindu University, Varanasi, India. He has awarded DST Inspire faculty award in 2016. He is currently working in the reputed organization AIIMS, New Delhi as an Assistant Professor. He is working in the Immunology, and drug discovery. He has published more than 20 papers in reputed journals and has been serving as a reviewer board member of repute. He has supervising 2 Ph.D. student and running 3 project.
Pharmaceutical Biomaterials; a coherent combination of medical basic sciences, pharmaceutical sciences, and innovational engineering.
Ismaeil Haririan received the Pharm.D in Pharmacy by working on SAR (structure-activity relationship) of drug molecules from state University of Tabriz (Iran) in 1986 and got his Ph.D in pharmaceutics and physical pharmacy (1989-1994) from London School of Pharmacy (UK). Returning back to his country, he joined to Tehran School of Pharmacy as an assistant professor in 1994. He was promoted to associated professor in 2000 and to full-professor in 2011. Apart from some significant works on novel drug delivery systems, his scientific attempts was focused on biomaterials and nanotechnology. His contribution can be seen in more than 100 papers and conference articles and training of many graduate and postgraduate students. Professor Haririan is the founder of Pharmaceutical Biomaterials as a novel Ph.D field and director of the center for research in Medical Biomaterials (MBRC), as well as the director of Department of Pharmaceutical Biomaterials at TUMS.
Polymeric Biomaterials for Health Applications
Dr. Marya Ahmed is an assistant professor in department of chemistry and Faculty of sustainable design and engineering at University of Prince Edward Island, Canada. She acquired her PhD in chemical engineering, from University of Alberta, with expertise in synthesis of polymeric vectors for gene delivery. As postdoctoral fellow, at California Institute of Technology USA, she worked with antibody-targeted nanoparticles as anticancer therapeutics. During her postdoctoral fellow at University of Toronto, she was introduced to the field of peptide drug conjugates for antibacterial therapies. Ahmed research program at University of Prince Edward Island is focused on the development of well-defined polymers and peptide polymers hybrids to overcome drug resistant disorders.
Evaluation of biological additives for enhanced durability properties of in situ subsurface soil.
Dr. Santosh Ramchuran has over 20 years of experience in the Biotechnology sector having held positions at African Explosives and Chemical Industry (AECI), SA Bio-products, CSIR, the Biotechnology Regional Innovation Centre - LIFElab and CellRx in the UK. He is a successful leader in science and technology with proven abilities in developing, implementing and commercializing innovative technologies, products and bio-processes in South Africa and internationally. He is also the Founder of JVS BioTech (PTY) Ltd a company which focuses on Bioprocess Development and Bio-manufacturing of high-value recombinant proteins. Santosh holds a PhD in Biotechnology from Lund University in Sweden and is currently completing a MBA. He is the author and contributor of several peer reviewed papers in the fields of applied microbiology, bioprocessing and recombinant proteins. He has expertise in developing and implementing strategic and operational plans, developing and nurturing key industry, academic and public strategic technology innovation and business partnerships that deliver value to the organization and stakeholders. His expertise in innovation management include: technology transfer, technology innovation investment, technology & business incubation, and project & portfolio management. He is adept at building and motivating high performing teams, enhancing operational effectiveness and leading cross-functional projects and teams to achieve organizational goals. He serves as a chairperson, moderator and assessor on various research and evaluation panels at the National Research Foundation in South Africa and was appointed as a Mentor for Biotech Start-ups at the Innovation Hub in 2015. He is currently the Research Group Leader for the Bioprocess Development Group at the Council for Scientific and Industrial Research which focuses on the development, optimization and bio-manufacturing of various disruptive bio-based products and technologies for adoption and implementation in South African industries. He also holds a Research Fellow position at the University of KwaZulu Natal and is a member of the South African Council for Natural Scientific Professions.
Li Li is PhD student from Southwest Jiaotong University, majoring in material science and engineering. My research mainly involves the surface modification of cardiovascular materials, multifunctional microenvironment construction and in-situ endothelialization.
Will be updated soon
THE EFFECT OF VEGF ON PROLIFERATION OF EUTOPIC AND ECTOPIC ENDOMETRIUM.Biography
Dr.Sung-Tack Oh is working as a Professor at Dept. of Ob/Gyn, Chonnam University Medical School, Gwangju, Korea. He also served as a Chairman (2009-2013) and Director (2005-2009) for the Department. He is a member of many esteemed Organization including AAGL (American Association of Gynecologic Laparoscopy and Minimally Invasive Surgery). He is also President of KES (Korean Society of Endometriosis)Abstract
There were many reports that various angiogenic factors, growth factors and cytokines related to progression of endometriosis. However the effect of vascular endothelial growth factor(VEGF) is still unclear. Therefore the purpose of this study was to determine the effect of VEGF on proliferation of endometrial stromal cell in utopic and ectopic endometrium. Methods: The utopic endometriums were obtained from 10 normal women by endometrial curettage, and 10 cyst walls (ectopic endometrium) of histollogically proven endometrioma were by laparoscopic cytectomy. The effect of VEGF on stromal cell proliferation was studied by culture with VEGF 0, 10, 50 and 100 ng/ml and by autoradiography with 3H-thymidine. Results: The addition of VEGF into endometrial stromal cells stimulated the proliferation of stromal cells in both utopic and ectopic endometrium. However there was no statistical differences among stimulation effect of growth after adding VEGF. Conclusions: VEGF plays an important role on proliferation of endometriotic lesion and normal endometrium.
Fabrication of Alginate/Honey Scaffolds by 3D bio-printing and studying their Mechanical, Morphological and Cell Viability Properties for in-situ Skin Tissue Engineering ApplicationsBiography Abstract
3D bio-printing process is a very rapid and vigorous process which is used for fabricating the in-vitro biological functional tissues. For printing an effective scaffold, it is very imperative that the printed structure must have an adequate strength and stiffness for keeping structural veracity. Alginates is such a biomaterial which can be used as a bio-ink for printing the 3D biological scaffolds. Also, the bio-ink gel must not be very strong enough as because more viscous results huge shear force for extruding the bio-ink from the nozzle which may result in cell fracture and death. Alginate is such a biocompatible and healthy material for cell. There are many applications of the alginate bio-ink in bone, adipose tissue engineering and in vascular field. Honey is a conveniently available natural material, known for its role in wound healing and skin tissue regeneration. However, honey blending to improve biological response of alginate-based bio-printed scaffolds has not been yet reported. In the present work, honey-alginate bio-inks were evaluated for their printability property (shape fidelity). It was found that honey blending reduced alginate viscosity, which gradually affected bio-printing fidelity. Therefore, the concentration that provides for acceptable bio-printing along with improvement in cell proliferations is determined. It is concluded that honey blending improves cell response of alginate bio-inks and can be a facile approach to obtain bio-inks especially for in situ skin tissue engineering applications.
Porcine cholecyst derived scaffold as a cardiac-patch for myocardial repairBiography
Ms. Reshma S. Nair is a Senior DST-INSPIRE Fellow pursuing PhD at the Sree Chitra Tirunal Institute for Medical Sciences and Technology, an institute of national importance under the Government of India. She completed MSc in Biotechnology from University of Calicut with DBT Fellowship (2013). She had also qualified the Junior Research Fellowship (2015) of the Council of Scientific and Industrial Research (Government of India) and Graduate Aptitude Test in Engineering (GATE Biotechnology, 2013).Abstract
Ischemic heart disease due to obstruction of blood flow to myocardium is a leading cause of death. Among the various strategies employed for the treatment, the emerging field of cardiac tissue engineering aims to repair the infarcted myocardium using cells, scaffold and growth factors. This study explores the potential of a cardiac-patch fabricated out of decellularised porcine cholecyst to heal induced myocardial infarction in a rat model. Sub-acute myocardial infarction (MI) was induced under general anesthesia in Sprague Dawley rats by ligating the left anterior descending coronary artery and the cardiac-patch was grafted over the infarcted site within 15 minutes. On the 14th day, the rats were euthanized by CO2 inhalation and heart was explanted. The nature of healing reaction in the graft-assisted and the non-assisted myocardium was compared by histomorphology. The graft-assisted healing was characterised by minimal collagen deposition and increased angiogenisis. It was concluded that decellularised porcine cholecyst is a potential biomaterial for fabricating cardiac-patch for assisted healing of infarcted myocardium.
Composite hydrogels of cholecystic extracellular matrix and polyethylene glycol diacrylate for skeletal muscle tissue engineering.Biography
Reshmi Raj is a research scholar from Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology. She completed her masters in Biotechnology from Cochin University of Science and Technology. She also obtained M.Phil. in Biomedical technology from Sree Chitra Tirunal Institute for Medical Sciences and Technology. Her academic achievements include first rank in M.Sc. from Cochin University, Research Fellowship from Kerala State Council for Science, Technology and Environment (KSCSTE), Govt. of Kerala (2014). She has two research publications in peer reviewed journals. Her research work is based on choleystic extracellular matrix hydrogels for skeletal muscle tissue engineeringAbstract
Extracellular-matrix (ECM) based hydrogels, prepared from decellularized mammalian tissues have recently emerged as scaffolds for tissue engineering applications. Porcine cholecystic ECM (C-ECM) is a novel decellularized scaffold that have been shown to have several potential biomedical uses. However, similar to other protein-based hydrogels, the C-ECM hydrogels also possess limited range of mechanical properties. This study aims to modulate the properties of ECM hydrogels by incorporating with a polymer (polyethylene glycol diacrylate, PEGDA) to create a C-ECM-PEGDA composite hydrogel. For this, different concentrations of PEGDA (0.2%, 0.5%, 1% and 2% w/v) and C-ECM (1% w/v) were blended to form four different formulations of C-ECM/PEGDA. Gelation was induced through redox-crosslinking by addition of ammonium persulphate and ascorbic acid. The conjugation of PEGDA with C-ECM was confirmed by infrared spectroscopy. The ‘storage modulus’ was consistently higher than ‘loss modulus’ for all hybrid formulations compared to the C-ECM-hydrogel, indicative of gelation. When evaluated by scanning electron microscopy, the hydrogel formulations maintained the original mesh like fibrous architecture of the native C-ECM. All the hybrid systems had significantly low degradation rates compared to the C-ECM. In vitro biocompatibility studies on skeletal myoblast cells (C2C12) revealed that, hydrogels with lower concentrations of PEGDA (0.2% and 0.5%) was non-cytotoxic. The rate of cell proliferation was also high in the hydrogel systems with lower PEGDA concentrations. The study demonstrated that blending of PEGDA to C-ECM can be acheived by redox cross-linking and that the hybrid C-ECM/PEGDA with regulated content of PEGDA has potential use in skeletal-muscle tissue engineering.
Coating of a porcine cholecyst derived scaffold with cell adhesion molecules improves angiogenesis.Biography
Ms. Manjula Puthuparambil Mony completed Bachelors degree (1st rank) and Masters degree (2nd rank) in Biochemistry from Calicut University, India. She obtained her MPhil in Biomedical Technology from Sree Chitra Tirunal Institute for Medical Sciences and Technology(SCTIMST) Thiruvananthapuram, India. Currently she is a Research Scholar at SCTIMST by availing the research fellowship from Council of Scientific and Industrial Research (CSIR), India and she is working on graft assisted healing of diabetic wound. She has received a Trainee Award at World Biomaterial Congress (WBC-2016), held at Montreal Canada.Abstract
The use of tissue engineering scaffolds prepared from extra-cellular matrices (ECM) of mammalian organs has been evolved as a promising approach for diabetic wound healing applications. The host laboratory uses an ECM scaffold namely porcine cholecyst derived scaffold (PCDS), prepared by a non-detergent/enzymatic method for wound healing applications. The present study explores the potential of PCDS for diabetic wound healing application. The ability of a tissue engineering scaffold to promote angiogenesis is an essential biomaterial property which contribute to diabetic wound healing. Considering this, attempts were made to modify the PCDS by cell adhesion molecules gelatin, fibronectin or CCN1, that support the growth and proliferation of endothelial cells. The coating of the molecules on PCDS facilitated the enhanced growth of human keratinocytes (HaCat) in comparison with an unmodified scaffold. The coating also promoted the adhesion, viability and proliferation of HUVEC (human umbilical vein endothelial cells). It can be concluded that the coating of PCDS with cell adhesion molecules may be a useful strategy for enhancing the potential of PCDS in healing of diabetic wound.
Preparation and characterisation of an injectable hydrogel from porcine extracellular matrix.Biography
Mr. Pratheesh K.V. is a research scholar from the Division of Experimental Pathology, from Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), India. He has completed his Bachelor’s and Master’s degree in Biochemistry from the University of Kerala. He also obtained his MPhil in Biomedical Technology from SCTIMST, India. He holds a Junior Research Fellowship of the Council of Scientific and Industrial Research (CSIR), Government of India. He has published an article in the International Journal of Pharmacy and Pharmaceutical Research (IJPPR).Abstract
Injectable hydrogels are gaining great attention in the field of tissue engineering. They are ideal biomaterials for various biomedical applications including drug delivery and bioink for 3D bioprinting technology because of the ease of tunability and biomolecule retention. Hydrogels in biomedical use are made of a polymer alone or in combination with biological materials. Various natural and synthetic crosslinkers have been used for the preparation of such hydrogels. These cross linkers ensure stability and sufficient mechanical properties.. This study aims to develop a hydrogel from porcine cholecyst extracellular matrix (C-ECM) by using a synthetic cross linker, polyethylene glycol (PEG). Results of the physicochemical and biological characterisation of the C-ECM hydrogel indicated excellent biocompatibility and ensured satisfactory biomaterial properties as an injectable hydrogel. The retention of the key original biomolecules of the C-ECM in the formulation, provides cues for its projected biological functions. Thus, the developed C-ECM-PEG hydrogel may have end use application as an injectable hydrogel for biomedical applications.
109Cd and 131Cs radionuclidies for radiotherapy in biodegrading biopolymer granulesBiography
In 1982 Abdisamat Vasidov defended his PhD degree at the Institute of Nuclear Physics of Uzbekistan Academy of Sciences (INP UzAS). Scientific directions include the activation analysis on the charged particles of a cyclotron and on neutrons of the nuclear reactor and radon monitoring by means of solid state track detectors and others. He has published 3 monographs and more than 100 articles in journals and collected papers. At present he is a leading staff scientist at the INP UzAS and works on obtain technology of the X-ray radioisotopes for radiotherapy.Abstract
In this work there were presented obtaining methods of X-emitter radionuclides of the 109Cd and 131Cs, after long irradiations targets of cadmium and barium at nuclear reactor. On base of 109Cd and 131Cs radionuclides have been created X-emitter biopolymer granules with biocompatible and biodegrading properties. The chitosan sorbent that synthesized from cocoons of a silkworm was used with various modified additives. For the 109Cd and 131Cs has been enriched more 50% and 98% sorption coefficients. The chitosan solution by adding to mix of potassium ferro (II) cyanide (K4[Fe(CN)6]) with copper and other chloride additives. The X-emitter granules have been formed by using setting bath, where the radioactive drops from syringe were passed through air layer and through solutions of the xylene and alkali sodium. The granules have been crosslinking with glutaraldehyde solution for hardness and hermeticity. The diameters and radioactivities of 109Cd and 131Cs granules have been regulated within 0.5 – 1.0mm and 2.0 – 10.0mCi.
Antimicrobial peptides for prevention of bacterial biofilm formation on the surface of bone cementBiography
Dr. Václav Čeřovký has completed his PhD from Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences and postdoctoral studies from IUPUI, Indianapolis, USA and Cornell University, Ithaca, USA. Then he was awarded with the Alexander von Humboldt fellowship to work in Leipzig University, Germany and in Forschungszentrum Jülich, Germany. At present he works as the leader of a research group dealing with antimicrobial peptides. He has published around 70 original papers listed in Web of Science.Abstract
Antibiotic-loaded polymethylmethacrylate-based bone cement has been implemented in orthopaedics to cope with implant-related infections associated with the formation of bacterial biofilms. This cement is commonly used in the form of beads or spacers for antibiotic release to the localized sites of infection and as a means for the fixation of joint replacements. With a view to emerging bacterial resistance to current antibiotics, we examined here the efficacy of short linear α-helical antimicrobial peptides (AMPs) incorporated in bone cement. These peptides composed of 12 amino acid residues, when released from model implants made of polymethylmethacrylate-based bone cement, significantly reduced bacterial adhesion and subsequent biofilm formation on the implants’ surfaces when exposed to growth media containing various bacteria. In addition, we assessed the formation of microbial biofilm on the surface of bone cements loaded with AMPs or unloaded when these were implanted into the infected spongy part of bone sample. As a result, biofilms did form on control implants made from the plain cement, while AMPs loaded in bone cements prevented formation of bacterial biofilm on their surface. The effect of the peptides was proven against methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli. The experiments showed that studied AMPs were more efficient in preventing biofilm formation than the antibiotics such as vancomycin or gentamicin, and the peptides exhibited broader specificity than did these antibiotics. Considering the problematic nature of antibiotic resistance, the AMPs show promise as a supplement to, or substitute for, antibiotics loaded into bone cements.
Biocompatibility of a novel ultrahigh-purity Iron and its practical applicationBiography
Luqman Khan currently works at the Graduate School of Life Sciences, Tohoku University, Japan. He does research in Zoology, Human Genetics, and Drosophila Genetics. His current research interest is “Biocompatibility of a novel ultrahigh-purity Iron and its practical application”Abstract
Metals and metal alloys are generally used as prosthetic materials for bone and tooth tissue reconstruction. The most common materials are cobalt-chromium-nickel, titanium-aluminum-vanadium, and commercially pure titanium. Iron is an essential mineral for all organism, however too much iron is extremely toxic. One of the co-authors, Dr. Kenji Abiko succeeded in purifying 10 kg ingot of ultrahigh-purity (UHP) iron of 99.9989 mass % (Abiko et al. 1998 Phys. Stat. Sol. 167, 347-356. Abiko 2002 Encyclopaedia of Materials: Science and Technology ISBN: 0-08-043152-6, pp. 1-9). The chemical nature of UHP-iron is quite different from that of conventional pure iron (cp iron). It hardly corrodes in hydrochloric acid. We, therefore, conducted experiments using cultured cells on the biocompatibility of UHP-iron. The growth of mammalian cells (i.e. MDCK, C2C12, and MSC cells) was inhibited by increasing 0.01 mM FeSO4 concentration and the presence of cp-iron plate (0.5 mm x 0.5 mm). In contrast, the growth was not inhibited in the presence of UHP iron plate (0.5 mm x 0.5 mm). Intriguingly, the cells adhered and proliferated well on the surface of UHP iron plate, as similar to on the surrounding plastic areas. Moreover, the C2C12 myoblast and MSC stem cells could be normally differentiated to myotube and osteoblast on the surface of UHP iron plate, respectively. In addition, as compared to UHP iron plate, the adhesion and proliferation were much lesser on the surface of commonly used cobalt-chromium-nickel and titanium-aluminum-vanadium metal plates. These results strongly suggested the possibility that UHP iron would be a novel biocompatible prosthetic material.
Magnesium Alloy-Like Fibers Fabricated Using Electrospinning and Heat TreatmentBiography
Hilal T. Sasmazel has completed her BS, MSc and PhD from Hacettepe University, Turkey. She is an Associate Professor of Metallurgical and Materials Engineering Department at Atılım University, Turkey since 2007. She has published more than 30 papers in reputed journals and has been serving as a Management Committee Member in European Cooperation in Science and Technology (COST) Framework Actions MP1101, MP1206, FP1405, CA16122 and CA16119 as well as Branch President of Executive Council of ModTech (Modern Technologies in Industrial Engineering) Professional Association, Scientific Committee and/or Editorial Review Board Member of IRC (International Research Conference), ModTech and several other journals.Abstract
Metallic structures are conventionally fabricated with high temperature/deformation processes resulting the smallest possible microscopic structures in the order of several hundreds of micrometer. Therefore, to obtain structures with fibers smaller than 100 µm, those are unsuitable. In this study, electrospinning, a fiber fabrication technique commonly used for polymers, was adopted to fabricate a WE43 magnesium alloy-like fibrous structure. The aim is to adopt metallic WE43 alloy to regenerative medicine using tissue engineering approach by mimicking its composition inside of a fibrous structure. The solution required for electrospinning was obtained with water soluble nitrates of elements in WE43 alloy, and PVP or PVA were added to obtain a spinnable viscosity which was pyrolised away during heat treatment. Electrospinning parameters were optimized with naked-eye observations and SEM as 1.5 g salts and 5 wt.% PVA containing solution prepared at 90°C and electrospun under 30 kV from a distance of 12-15 cm with a feeding rate of 5 µl/min. Then the samples were subjected to a multi-step heat treatment under argon to remove the polymer and calcinate the nitrates into oxides which was designed based on thermal analyses and reaction kinetics calculations as 6 h at 230°C, 8.5 h at 390°C, 5 h at 465°C, 80 h at 500°C and 10 h at 505°C, consecutively. The characterizations conducted in terms of structure, composition and crystallinity with XRD, XPS, EDX and SEM showed that it is possible to obtain MgaYbNdcZrdOx (empirical) fibers with the same composition as WE43 in sub-millimeter sizes using this approach.
Engineering oral mucosal polymeric patches for the treatment of childhood on-set schizophrenia.Biography
Miss Laura Modica de Mohac is a pharmacist and a Ph.D. postgraduate researcher at the University of Palermo and at King’s College London under the supervision of Dr. Mariano Licciardi (U. of Palermo) and Pr. David Taylor (King’s College London) Dr. Bahijja Raimi-Abraham (King’s College London). Laura’s current research interests sit in increase research communication between pharmaceutics and clinical to improve therapy efficacy in childhood onset schizophrenia and treatment-resistant schizophrenia. Laura graduated with a Pharmacy degree (MPharm) from the University of Palermo, in 2016 and then registered with the Italian Pharmacist Federation as a pharmacist in December 2016. During her Masters, Laura also conducted a six months Erasmus Plus research project at University College of London under the supervision of Dr. Bahijja Raimi-Abraham.Abstract
Schizophrenia is a chronic and severe mental health conditon with a neurobiological background with prevelance in mainly adults and around 1% of paediatric populations worldwide. Childhood-onset schizophrenia (COS) is commonly diagnosed at adolescenece (~13 years of age) and treatment focuses on the identification of the most appropriate antipsychotic agents that will provide optimal efficacy without causing adverse events. The most significant clinical challenges in COS is non-adherence and poor patient compliance highlighting the need to develop appropriate (for the patient demographic) and tailored dosage forms to address this challenge. In our study, we have developed a novel oromucosal polymeric patch using two preparation methods namely solvent casting and solution electrospinning with excellent patient acceptability and suitability to be a delivery system for poorly water soluble drugs such as clozapine. Using the polymer α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA) which offers simultanous mucoadhesion and solubilisation combine with polyvinyl-alcohol (PVA) to create solid microcrystalline dispersion, the drug release mechanism from the patches are modified depending on polymer concentration and based on the method of preparation. The formulated films and nanofibres have been characterised in order to detect drug physicochemical properties through SEM, FTIR, XRD, DSC and permeation studies. The in vitro dissolution behaviour of films and nanofibres generated systems have then been compared as well as muco-adhesive properties on the buccal mucosa in AFM studies. Overall,both films and nanofibres increased clozapine release achieving a fast dissolving rate however, the nanofibers showed to have better muco-adhesive properties due to their high surface area.
Tunable surface properties of polycaprolactonecontainingmesoporous bioglassparticles membranesfor bone tissue engineeringBiography
Mr. Yu-Lun Chiang is a master degree student of the Graduate Institute of Biomedical Engineering of Chang Gung University in Taiwan. His research topic focus on surface modification for biomedical applications.Abstract
Interfacial interaction is the first contact between a medical device and a biological system. Scientists agree that the success of biomedical devices depends on their surface properties. Well-designed surface physical and chemical properties, such as the texture, net charge, and hydrophilicity, can enhance cell attachment to the surface or antifouling. Today there is worldwide agreement that the major factor determines successful ofbiomedical devices, ranging from implantable medical devices to cell culture tools and diagnostic devices, depends on their surface properties. A broad range of surface modification methods have been developed to modify the surface of biomedical devices. The present study describes a water-based surface modification method that has the ability to alter any substrate materials. Numerous of approaches have been developed to improve wettability, to create a friendly interface for cells and to functionalize surface. The present modified process is a green process because no any organic solvents, initiators and catalysts be used.In this work, mesoporous bioglass(MBG) nanoparticles distributed inPCL films were surface modified by polymerisation of aminomalonitrile (AMN) with 3,4,5-trihydroxybenzaldehyde (THBA). Results indicated that substrate surface with a layer of AMN/THBA polymer enhanced hydroxyapatite formation compared with non-treated ones. Besides, osteoblast cells expressed lower extension and mineralization levels on non-treated substrate than on AMN/THBA modification mambranes. Together our results demonstrated that present work provide a simple method to alter surface properties.