Several genetic, molecular, epigenetic findings have been suggested to explain the role of dyanamic adaptations and alterations within the the cells and their outside nices. These network of genetic, molecular and epigenetic events have been central to various intricacies of life and death, cellular responses external clues. However, several questions are still remaining unsettled with reference to cellular signaling adaptations with reference to new forms of external clues in the form of social networking, which is completely different from the well studied environmental factors such as pathogens, chemical signals, physical signals and stress signals. Therefore, understanding the influences of social networking such as faceboo, internet, instagrams and many more based generated signals to shape up the adaptation of huma intra- and inter cellular signaling adapations may reveal new facets of crosstalk at the level og genetic, epigenetic and social networking driven adaptations.
Currently, it is not knwon and possibly clear evidences are lacking whether signals/clues emanating from scoial networking driving changes at the interface of molecular signaling, genetic and epigeentic level. Of couse, if there are any changes, then these changes in intra- and inter cellular signaling network could be linked to the pathophysiological state either pro-disease or anti-disease condition. It appears interesting to extend hypothesis to cancer pathophysiology and its treatment moudlations due to the possible crosstalk between social networking and intra- and inter cellular networking in a cancer patient. In future perspectives, state of the art tools and techniques to decipher alterations in the cellular signaling landscape at molecular, genetic and epigenetic landscape may provide answers to above proposed concept and could pave the way of better understanding of social adaptions of users of social networking tools, and if any impact on the human disease conditions for an example cancer pathophysiology. The author suggests that system biology, transcriptomics, proteomics and epigenetic tools could be performed on animal model or human model to observe changes in the cellular signaling wiring due to the social networking emanated clues/signals. The impact of this hypothesis and experimental apporcahes may help to achieve milestone towards personalized medicine. Since, in the current era of drug development, contribution of external signals and factors in the form of social networking should be highlighted and emphasized for any drug regimen to patients. In this hypothesis, we summarize the importance of social networking to drive intra- and inter-cellular signaling adaptations in the perspective of fundamental of evolution of human cellular organization, personalized medicine and biomarkers of if any disorders associated with the negative imptact of social networking.
Key Words: Epigenetic events, Life, death, Cancer, Gene, Epigenome, Environment, Social networking, Cellular signaling
"Dr. Nilesh Kumar Sharma is a Associate Professor, Department of ""Biotechnology in D.Y. Patil Biotechnology & Bioinformatics Institute, India. His area of specialization is DNA repair and drug resistance in cancer and his experimental methods are Human carcinoma, normal cell line and carcinoma patient tissue."