Abstract

Porphyrin has been proven to be an efficient photosensitizer for photodynamic therapy (PDT). However, the problem of undesired localization in non-tumour environments which causes prolong photosensitivity and requirement for more dose has lowered its therapeutic efficacy. To make porphyrin tumour specific, we have successfully conjugated a meso-substituted symmetric 4-hydroxyphenyl porphyrin (THPP) to superparamagnetic iron oxide nanoparticles-gold core-shell nanostructure (SPIONs-Au) via a facile green approach. The SPIONs were precipitated in an alkaline medium from a preheated mixture of glucose and ferric ion before coating with gold. The core-shell nanostructres were characterized using UV-Vis, FT-IR, XRD, TEM, HRTEM, SAED, EDS and vibrating sample magnetometry(VSM) while the conjugate was characterized using UV-Vis, Photoluminescence spectroscopy (PL), FTIR, DLS and Zeta potential. The as-synthesized magnetic porphyrin conjugate exhibited strong attraction towards external magnetic field and high singlet oxygen generation potential sufficient for the eradication of breast cancer cells in vitro