Abstract

The objective of this work was it the synthesis and characterization of biopolymer-magnetic nanoparticles by the deposition layer by layer � LBL technique for encapsulation and controlled release of the curcumin. MnFe2O4 nanoparticles were obtained by alkaline coprecipitation with subsequent functionalization of their surface by the LBL technique, using chitosan and chondroitin sulfate alternately. The encapsulation of the curcumin in the nanoparticles occurred by addition of an ethanolic solution of curcumin (0.3 mg/mL) in the chitosan solution. The nanoparticles showed low PDI, hydrodynamic diameter in the range of 227 nm and zeta potential, depending on the pH and polymer added. The nanoparticles also were characterized by FTIR, Raman, XRD, XPS, magnetization, TGA, TEM, ICP-OES and magnetohyperthermia. The encapsulation efficiency of curcumin was evaluated by fluorescence spectroscopy, obtaining 59.5, 30.3 and 69.1 % in the layers 2, 3 and 4, respectively. The controlled release of the curcumin occurred gradually, by diffusion mechanism