1Department of Oncology of Grodno State Medical University, Belarus 2Department of Biochemistry of Yanka Kupala Grodno State University, Belarus On the basis of the experimental data we suggest that the differences discovered in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostics of primary cancerous growth as well as in estimation of the efficacy of specific cancer treatment. Clinical studies on biological fluids and tumors of 1,495 patients with cancer of the mammary gland, lungs, prostate, ovaries, bladder or digestive tract showed significant changes in physiological concentrations of amino acids which either directly or indirectly regulate processes of antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a targeted effect on the functional and metabolic relationships which are changed in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application of their regulatory effects in oncology was discussed.
studies: 2012 - present: Subintern of Department of Oncology of Medical Faculty of Grodno State Medical University, Belarus. The fundamental scientific activities is studying molecular mechanisms of metabolic regulation with a design of novel medicinal preparations based on highly purified L-amino acids, their derivatives and compositions. Participation at about 7 scientific meetings. Author of 10 articles and academic publications in journals in general and applied oncology. Current research interests related with mechanisms of realization of antitumor drugs, amino acid pool formation and clinical applications of amino acids.. Karavay P. Metabolic comfort in oncology and free amino acids: perspectives for the use of their regulatory actions in physiological concentrations