Biography: Michał Michalik specializes in otolaryngology, head and neck surgery and aviation medicine. Founder of the first Snoring Center in Poland - Center of Snoring Treatment. For treatment of this disease introduced the technique of Coblation, radiosurgery, harmonic technique and implants used to correct the throat and soft palate. As the only one in Poland he also started the innovative Repose THS. In 2010 he was honored by two of the most prestigious sleep disorders associations - American Academy of Sleep Medicine and International Surgical & Sleep Society
The aim of this study was to investigate whether or not surgical biopsy of sinus tissue in chronic sinusitis, not responsive to treatment, would detect E. coli. We intended to evaluate E. coli virulence genes, therefore dispute the causal role of such an unusual microorganism in chronic sinusitis, as well as consider effective pathogen-targeted therapy. Patients with E. coli isolated by intra-operative puncture biopsy were included in the study. Genetic analysis of E. coli isolates, including phylogenetic grouping and virulence factor characteristics, were done by multiplex PCR. We identified 26 patients with chronic sinusitis, in which 26 E. coli isolates were cultured. The E. coli isolates belonged mainly to pathogenic phylogenetic group B2, and carried multiple virulence genes. Three genes in particular were present in all (100%) of examined isolates, they were (1) marker agn43 gene for forming biofilm, (2) type 1 fimbriae (fimG/H gene) and (3) yersiniabactin receptor (fyuA). Furthermore, a pseudo-phylogenetic tree of virulence genes distribution revealed possible cooperation between agn43, fimG/H, and fyuA in the coding of biofilm formation. Intra-operative-biopsy and culture-based therapy, targeting the isolated E. coli, coincided with long-term resolution of symptoms. This is the first report demonstrating an association between a highly pathogenic E. coli, chronic sinus infection, and resolution of symptoms upon E. coli targeted therapy, a significant finding due to the fact that E. coli has not been considered to be a commensal organism of the oropharynx or sinuses. We postulate that the simultaneous presence of three genes, each coding biofilm formation, may in part account for the chronicity of E. coli sinusitis
Senior Assistant in Department of Otolaryngology, Medical University of Lodz, Norbert Barlicki Memorial Teaching Hospital, Lodz, Poland Postgraduate qualifications: 05.06.2019 completed Ph.D - Awarded by university of: Medical Academy in Lodz, Poland Professional qualification: 2018 Medical license in Otolaryngology Date of graduation: 2005-2011 Faculty of Medicine of the Medical University of Lodz Published papers in reputed journals with and IF – 8,417; MNiSW – 140 pkt.
Background: The aim of the present study was to identify specific serum miRNAs (preoperative serum samples compared to healthy controls) as potential diagnostic markers for detection in laryngeal squamous cell carcinoma (LSCC). Serum samples obtained from 66 patients with LSCC were compared with 100 healthy control subjects. Additionally, miRNA levels were evaluated to identify possible correlations with clinicopathological features. Methods: The expression of 377 miRNAs (screening set) was evaluated by microarray screening. The most differentially expressed miRNAs were validated by high-throughput real-time quantitative polymerase chain reaction (RT-qPCR) in the group of LSCC patients and healthy controls. Receiver-operator characteristic (ROC) curve analysis was conducted to evaluate the diagnostic accuracy of the highly and significantly identified deregulated miRNA(s) as potential candidate biomarker(s). Results: According to the array analysis, eleven miRNAs revealed an altered expression profile. The levels of serum expression of miR-31, miR-141, miR-149a, miR-182 , LET-7a, miR-4853p, miR-122 and miR-33 were up-regulated, and those of miR-145, miR-223 and miR-133a down-regulated, in the LSCC group compared to healthy controls. ROC curve analyses revealed an AUC (area under the ROC curve) of 1.00 (95%Cl: 0.999-1.00; P<0.001) for miR-31 and LET-7a, 1.00 (95%Cl: 1.00-1.00; P<0.001) for miR-33 respectively, indicating that these three miRNAs had an additive effect regarding diagnostic value. No statistically significant differences were found between the serum levels of these eleven miRNAs and the tested clinicopathological features. Conclusion: Our findings outline a distinct miRNA expression profile in laryngeal cancer (LC) cases which can be used to diagnose LSCC patients with high sensitivity and specificity. Particular miRNA signatures (miR-31, LET-7a and miR-33) may be considered as novel, non-invasive biomarkers for LC diagnosis.
University Hospital of Crete Oral and Maxillofacial surgery. Greece
Introduction: Solar cheilitis (SC) or cheilosis or actinic cheilitis is a well known premalignant condition of the lip skin (vermilion). In SC of the lower lip, the potential to develop into squamous cell carcinoma (SCC) is increased compared to the upper lip, due to higher risk of sun exposure. Aim: to present case series of SCC or SCC associated with SC, which were excised by vermilionectomy. Material - methods-results. During an 18 months’ time period between 2010 and 2012, 9 cases of SCC of the lower lip were treated. In 3 of them coexisted clinically severe SC. After Dermatologic, ENT examinations, incisional biopsy and histopathologic evaluation in all 9 patients, vermilionectomy was performed by V(on 6) or W(on 3) patients respectively. In one patient a superficial second primary SCC at the area of vermilionectomy, was found. Moreover on 3 patients severe epithelilal dysplasia was discovered. The operations performed under local anesthesia with anesthesiology support by using proper doses of Remifentanyl and Midazolam. No complications were encountered during the procedures. Conclusions. Vermilionectomy is a safe, useful quite simple operation, which should be in the armamentarium of the physician who deals with vermilion neoplasms. SCC or second primary malignancies could coexist with SC due to the field cancerization phenomenon. Vermilionectomy is recommended for the removal of epithelial dysplastic disorders or SCC on the lips decreasing the risk of recurrences. Local anesthesia in conjunction with modern anesthesiology procedures could be more than enough in such operations. No relapse or new malignancy development was seen during the24 months close follow-up of our patients.
Wondu Reta has completed his BSc and MSc degree from Jimma University. He is the researcher and lecturer of Anesthesiology and Medical Physiology at Jimma University, Institute of health. He has published many papers in reputed journals and also serving as reviewer and editor at different journals related to his profession.
Cardiac arrhythmias are common in COPD patients and are a major cause of morbidity and mortality. The present study aimed to determine the prevalence of cardiac arrhythmias among patients with COPD. The study was conducted on COPD patients visiting chest clinic of Jimma Medical Center (JMC) located at Jimma town, South west Ethiopia; from May 18 to August 18, 2017 G.C. A hospital based cross-sectional study was conducted among 80 sampled COPD patients; and an investigation for 12 Lead resting supine ECG was performed. The prevalence of arrhythmia accounted for 50% and the magnitude of its types were classified as Sinus origin arrhythmia (30%) specifically [Sinus bradycardia (16.3%), Sinus tachycardia (8.8%) and Sinus arrhythmia (5.0%)], Ectopic arrhythmia (20%) specifically [Premature ventricular Contraction (7.5%), Atrial fibrillation (6.3%), Premature atrial contraction (3.8%), Atrial flutter (1.3%) and Multi focal atrial tachycardia (1.3%)], Conduction block arrhythmia (23.8%) specifically[Bundle branch block (17.5%) for instance: Complete right bundle branch block (3.8%), Complete left bundle branch block (5%), Incomplete right bundle branch block (7.5%), Incomplete left bundle branch block (1.3%), Hemi fascicular block (5%)] and Atrioventricular block (1.3%)], and Other arrhythmia (11.4%) like Prolonged QTc interval (8.8%) and Preexcitation syndrome or Wolf Parkinson white syndrome (2.5%) as a single COPD patient presented with more than one arrhythmias. Thus routine ECG investigation should be performed at the setup to screen and initiate early management of Cardio vascular diseases including cardiac arrhythmias for better prognosis COPD patients which was inevitable and very common.
Kharoubi Smail, professor - ENT head and neck surgery & ORL. Department of ENT head and neck surgery. Dr. Dorban- Hospital. Chu Annaba -Faculty of Medicine - University of Badji Mokhtar Annaba 23000 Algeria. His research interests are Rhinology, olfactology, reconstructive surgery, pediatric ENT, rare tumors in ENT, genetics and ENT, robotics and ENT.
We report an observation of a 63-year-old patient who had consulted for progressive right nasal obstruction, epistaxis and deformity of the nasal pyramid. The clinical examination shows edema with widening of the root of the nose. The palpation notes a depression of the area of nasal bones with elastic sensation. Nasal endoscopy shows obstructive tumor of gray color in the right nasal fossa pushing the nasal septum towards the contralateral side. The cervical examination does not find cervical lymphadenopathy. The CT scan shows an tissue density lesion with imprecise limits of 37 X 24 mm in the anterior part of right nasal cavity. This lesion is raised heterogeneously after injection of contrast. There is nasal bones osteolysis with integrity of the neighborhood structures. Endonasal biopsy noted a moderately differentiated squamous cell carcinoma. The pre-therapeutic assessment is without particularities. The patient is operated by lateral rhinotomy. There is an40X25 mm ovalar tumor easily cleavable with septal implantation. The anatomopathological study of the surgical specimen has showed a pleomorphic adenoma of the nasal septum. The pleomorphic adenoma is a benign tumor most often located in the main salivary glands. It's location in the nasal cavity is exceptional. Surgery is the best therapeutic choice. Management of the pleomorphic adenoma of the nasal cavity most to be considerate the tumoral site, the aesthetic complications and evolution in future of this tumor. Long-term following is necessary because risk of recurrence or malignant degeneration.