Scientific Program

Keynote Talks

Abstract

In our society, states of stress and anxiety are frequently connected with binge eating disorder. Preferred foods tend to be chocolate, carbohydrates, milk and milk derivatives. These foods have a strong impact on the emotional gratification. Food abuse upsets intestinal balance and connected malt (oral, nasal, respiratory, etc…) to the extent of causing asthma and allergies. Binge eating disorders can and must be overcome without giving up the pleasure of eating. This is the very essence of Pneisystem. Pneisystem is a method of integrated diagnosis and systemic therapy based on alkaline diet, stress management techniques, state of the art supplementation, exercise and low dose therapies. We recently defined the “Pneisystem Zone” which describes a state of pshyco- physical wellbeing and empowering actitude towards food in general.

Biography

Maria Corgna completed her Ph.D in Medicine at the University of La Sapienza and Specialization in Endocrinology at the University of Tor Vergata. She extensively investigated Psychoneuroendocrinoimmunology since the year 2000 and created a method of integrated diagnosis and treatment known as Pneisystem. Pneisystem is based on epigenetics and considers therapy the result of 4 main types of intervention: stress management, nutrition, physical exercise and integrated therapies. It also considers Environmental Medicine essential.

Speaker
Maria Concetta Corgna / MD Specialist in Endocrinology
Teacher and Expert of Psychoneuroendocrinoimmunology
Italy

Abstract

Japanese centenarians were 153 in number in 1963, and 65,692 in 2016, and in 2030’s, it is expected that 80 % of the Japanese aged people will be able to live with keeping good health. The longevity secret is in life habit, i.e., dietary habit combined with aerobic exercise. Such life style leads to physical strength, intelligence, and vitality owing to active mitochondria in liver, muscles, brain, heart, and kidney. Most Japanese have dietary habit of eating seaweed “kelp” in various ways because it contains essential element for good health, iodine. About 100 years ago, doctor of pharmacy, Makino bothers and their physician group succeeded in using iodine element for remedy of all kinds of diseases. They developed iodide-ion containing oral medicines by getting a hint from iodine-containing human growth hormone. The late Medical Dr. Noboru Iijima, a physician, used the oral iodine medicine for medical treatment toward almost all diseases until 1978. Because of revised Pharmaceutical Affairs Law, the iodine-containing supplement called “organic iodine” or “Seiyoutan” is now on internet-sales or by word of mouth as a supplement for sustaining mitochondria activity.
Mitochondrion’s job is to produce chemical energy of ATP by reductive phosphorylation by superoxide anion radical (O2.-) that is produced from triplet oxygen molecules (3O2) and glucose from food. However, O2.- may happen to be converted into hydrogen peroxide (HOOH) by hydrogen abstraction from glucose. Increased HOOH production leads to increased production of hydroxyl radical (HO.), which causes mitochondrial damage and decrease in energy production. Computational molecule modeling, i.e., an artificial intelligence (AI) of physics and chemistry, successfully verifies and predicts what are happening in mitochondria. Excellent role of iodine element will be disclosed in view of mitochondria sustainability.

Biography

Shozo Yanagida is an active emeritus professor of chemistry, Osaka University. He got a PhD degree while he was an assistant professor of Osaka University (1970). The chemistry thesis entitled “Studies on nitriles with carbonyl dichloride” attracted much attention as one-pot synthesis of pyrimidine ring of nucleic acids Since he became professor (1980) of Graduate School of Molecular Process Engineering established newly in Osaka University, he challenged to researches for construction of artificial photosynthesis, and moved to researches on solar cells. At present, he engages himself in computational verification of iodine-based dye-sensitized solar cells (DSC) and perovskite solar cells (PSC) as research director of “Research Association for Technological Innovation of Organic Photovoltaics” (RATO) of University of Tokyo. He is a representative director of M3 Laboratory, Inc. established at ISIR, Osaka University.

Speaker
Shozo Yanagida / Osaka University
Japan

Abstract

As the discovery of new compounds simultaneously efficient, long lasting pharmacologically active and without/ few side effects have become one of the most interesting topics in pharmaceutical research, the nature became a valuable source for bioactive raw material of primordial importance. Keeping in mind this perspective and the richness and diversity of Romanian flora, ICCF, based on its tradition and expertise, develops a wide range of herbal products from the stage of idea to finished products by corroborating technological, analytical and pharmacological results. Medicinal plant research contributes also to the efficient valorization of the Romanian plant biomass by developing high added-value products and to a more accurate characterization of indigenous less studied plant species.
The relationship between the structure and function of plant compounds are basic conditions for drug-design activity and for the obtainment of high activity medicinal products, with a superior benefit/risk ratio.
The research subjects and directions are continuously updated; the research topics cover a wide range of forward-looking issues – from designing new drugs for modern society diseases (diabetes, inflammation, stress, premature aging) and isolation of active phytocompounds with various uses (serin-proteases inhibitors, antioxidant molecules, nanoproducts containing iridoids) to medicines for veterinary pathologies (endometritis in cows, periodontitis in pets).
Finished phytotherapeutic products and the corresponding technologies developed in ICCF are usually transferred to SMEs, assisting the implementation of developed processes ensuring product quality or reliability of technology.

Biography

Misu Moscovici is the President - General Director of the National Institute for Chemical -Pharmaceutical Research and Development, Bucharest. He has done his Doctor of Medicine, Technology University Gh. Asachi, Iassy, Romania, 1972. Doctor of Philosophy, Technology University Gh, Chemical engineer Antibiotics Company, Iassy, 1972-1974. Research engineer Antibiotics Research Center, 1974-1980. Researcher Chemical-Pharmaceutical Research Institute, Bucharest,1980-1990. Moscovici is a Senior researcher in Chemical Pharmaceutical Research Institute, since 1990, head biotechnology department, 1990-1994, general manager, since 1994. Areas of activity: Mainly, the institute carried out basic and applied research, technology development in the fields of chemical and pharmaceutical, biotechnology, medicine; running and production of small tonnage to support and enhance scientific research.

Speaker
Misu Moscovici / 3S-Pharmacological Consultation & Research GmbH
Germany

Abstract

The total of the herbal, animal and mineral knowledge, used in the maintenance of health treatment of illnesses is traditional medicine .Based on the World Health Organization statistics, more than 80% of world population resorts to herbal remedies. Herbal therapy in Iran also dates back to a long time ago and a number of writings regarding this issue are left by great physicians e.g. Avicenna and Razes. Silk Road, The route to the 1700s of the 15th century was the largest commercial network of trade routes that connected the many different civilizations of Asia, Middle East, and Europe in the world. Iran, as a country located in between, played a key role for traded, silk, paper, bamboo, grapes, raisins, cotton, dye for porcelain, tea, dried fruit, medicinal plants, horses, rugs, nuts. Iranian botanists have led to recognition of around 150 spontaneous families of Angiosperms containing 124 Dicotyledonous, 22 Monocotyledonous and 4 Gymnosperms families. Totally there are about 1450 genera and 8000 species which nearly 2000 species are endemic. Iranian traditional medicine had cited pharmaceutical dosage forms, e.g. powders, syrups, ointment, extracts, mucilage’s, nectars, etc. Our remedy with herbal is based on the temperament as well as the knowledge concerning types of effects of part or extraction of herbal species on the body. From my research work, going to presenting the natural constituents and traditionally patients consuming herbal remedies in Iran e.g, Allium spp is a genus of monocotyledonous flowering plants that includes hundreds of species, including the cultivated onion, garlic, scallion, shallot, leek, and chives, Sabzi khordan is a common side dish in Iranian and Armenian cuisines, which may be served with any meal, consisted of any combination of a set of fresh herbs and raw vegetables e.g, Basil, parsley, and radishes are among the most common ones. It is sometimes served with feta cheese and bread and also walnuts. So know days in the world, herbal medicine tread a multi-billion dollar, international industry, and the biomedical sector is increasingly investigating the potential of genetic resources and traditional knowledge. So it is necessary for a protected herbals and product to be provided with information on its ingredients, indications, dosage, pharmacology, contraindications and possible side effects before a rational decision on its use.

Biography

Mohammad Bagher Rezaee is an Iranian scientist who works on Photochemistry or chemistry (Ag). And up to know did lot of research on cultivation, extraction, formulation, and produce products out of medicinal and Aromatic plants, designed pilot of essential oil extraction. He has published 6 Book in Persian and so many international and national papers. He is working as signoras' scientist in Research Institute Forests and Rangelands (RIFRI) -Tehran-IRAN. Rezaee is also the Chairman of Union Medicinal plants of Iran (UMPI) and deputy of Iranian medicinal plants society (IMPS). He got three national awards about selected and important medicinal plant as natural product or instead of synthetic medicine and biological uses.

Speaker
Mohammad Bagher Rezaee / Chairman of Union Medicinal
Plants of Iran.
Professor, RIFRI

Abstract

Based on data on archaeobotany and ethnobotany of the Holy Land, survey of the use of medicinal plants in the Holy Land throughout history as well as at the present time , and a revision of the medicinal plant of Assyria we suggest a new list of the Medicinal Plants of the Bible. While Duke and Duke (1983) enumerated not less than 176 plant species as “Biblical Medicinal Plants” and Jacob (1993) only 54, in our survey we suggest reducing that figure to 37. The overlap between Jacob’s list and ours is 19 species in total. Our contribution is 18 “new” suggested Biblical Medicinal Plants. This discrepancy is due to three reasons: 1. Not less than 22 species in Jacob’s list are not recognized today (Amar, 2012) as valid Biblical plants names at all, or they are not related to specific species. 2. Several identifications from Campbell-Thompson (1949), the only Mesopotamian source used by Jacob, are no longer recognized by modern Assyriologists. 3. Several Mesopotamian plants were only recently identified in medical context. Only five species are mentioned directly as medicinal plants in the Bible: Fig (Ficus carica), Nard (Nardostachys jatamansi), Hyssop (Majorana syriaca), Balm of Gilead (Commiphora gileadensis) and Mandrake (Mandragora officinarum= M. autumnalis ). Not less than 18 medicinal plants, additional to the Bible, are mentioned in old Jewish post-Biblical sources. Most of these plants (15) are known also in Egypt and Mesopotamia while 3 only from Egypt. Seven of the BMP’S species are not mentioned in the Bible or in the old Jewish Post- Biblical literature but were recorded as medicinal plants from Egypt as well as from Mesopotamia, and it is quite logical to assume that they can be included as BMP's. According to our survey, all the 37 suggested BMP’s are still in medical use today in the Middle East and are subjected, at the 21 century, to an active research in attempts; to understand their chemical composition and/or Medical activity and/or Isolation of new compounds for new drug development. Shakya (2016) mentioned “Top 25 Bioactive Compounds of Medicinal plants”, his list includes also : Curcuma longa, Ricinus communis, Piper nigrum, Aloe vera, Nigella sativa, Artemisia absinthium and Allium sativa = 19% of our list of Biblical Medicinal Plants!! As written in the Bible: “That which has been is what will be, That which is done is what will be done, And there is nothing new under the sun”. (Ecclesiastes 1:9)

Biography

Amots Dafni completed his Ph.D. in Botany at the Hebrew University in Jerusalem. His research areas include: pollination ecology, medicinal plants and ethnobotany with special reference to plants role in human culture. His publications include 150 scientific papers and 20 books e.g. "Pollination Ecology: The Practical Approach", "Sacred Trees of Israel" and with S.A. Khatib, "Plants, Demons and Miracles – Plant Folklore in the Bible's Lands". His current research is related to: Medicinal plants through history, Bible's plants and the multicultural and religious aspects of ritual plants.

Speaker
Amots Dafni / Professor
Haifa University
Israel

Sessions:

Scientific Sessions

Abstract

More and more non-pharmacological interventions (NPIs) are prescribed by doctors for patients, as complementary or alternative paths to conventional treatments. NPIs extends every day especially in the areas of nutrition, e-health and psychological adjustment to the disease. The aim of this work was to present models of clinical validation and surveillance of these health solutions. Material and method We conducted a literature review on the validation and surveillance models of NPIs. Results We identified thirty three models of validation and surveillance, inspired by drug, behavioral interventions, engineering. We have also identified hybrid model. To date, any model are leading. Conclusion Patient expectations against NPIs reported by the media and the arrival in the health sector of industrial from new technologies and nutrition require a consensual model of clinical validation and surveillance of NPIs. To date, no model predominates. This lack may multiply prescription errors and the risk of misuse. We will presented a model. We need a common framework, Not just for us researchers, but also to insure patient welfare, better professional practices and an economic basis for reimbursement.

Biography

Gregory Ninot is a Professor at University of Montpellier, France and the Founder and Executive Director of CEPS Platform, a collaboirative academic platform, thinking non-pharmacological interventions (NPIs) assessement methods. Ninot holds a PhD degree in Sports Sciences applied to Health and in Health Psychology. He has spent the last 20 years working on the evaluation of the efficacy of NPIs for people affected by chronic disease. He has published 124 articles in international scientific and medical journals, 10 books and 17 book chapters. He works also at the Cancer Centre of Montpellier. He has created a blog (blogensante) from his passion for reading key scientific and medical research articles, and from his desire to share NPIs researches.

Speaker
Gregory Ninot / University of Montpellier
France

Abstract

The oldest known therapeutic systems used by humans to promote health and well-being are called Traditional Medicine (then linked to folk tradition) or Complementary and Alternative Medicine (TM / CAM).
TM / CAMs are increasingly used, even in a formal context within healthcare delivery systems. If you practice properly, TM / CAM can help protect and improve the health and well-being of citizens. For the proper use of TM / CAM therapies and products, however, some important issues need to be considered.
What will we talk about? We'll talk about What's important to do to gain more credibility and what a strategic plan to develop to promote health and well-being in society.
- Understand who we are, how we do our job and set goals (identity)
- Understand who we are around and who are our collaborators (create community and network)
- Be able to analyze the surrounding reality in order to understand how the socio-economic sphere moves to opt for current and useful context choices (having eyes and minds open to reality)
- Collect data, elaborate them and develop an economically advantageous budget (budget) - To be able to understand well what we offer for the improvement of society (know who we are and how we do it)
- Be able to communicate ideas and projects (through the latest social media and communication tools)
These and other management concepts can be very helpful for improving the status of complementary and alternative medicine in the world

Biography

Andrea Rizza Osteopath D.O. was born in Sicily 17/01/91 and work and live in Rome. He has completed his studies at C.R.O.M.O.N. School of Osteopathy and attended the Master 1 level in Sciences Osteopatiques with Universitèè Europeenne Jean Monnet of Bruxelles. He work like Teacher Assistent and Clinical Tutor of EDUCAM school. He has actively participated and co-ordinated with various projects in the emergency and socio-political and humanitarian field

Speaker
Andrea Rizza / EDUCAM CROMON
Italy

Abstract

This presentation will contribute to the fields of urban ethnobotany and ethnoparmacology by examining the use of traditional healing plants and herbs by diverse Latin American groups in the United States. Based on a 10-year ethnographic study in New York City (NYC), Viladrich will analyze the role of botánicas (healing-religious stores) as main providers of herbs and plants to a pan-ethnic Latino population.
The plant-based healing knowledge and practice of botánicas is shaped by what is called the globalocalization of ethnobotany, in which local access to a varied supply of herbs and plants—many of which are shipped from Central America and the Caribbean—is informed y culturally specific beliefs and practices. The variety of healing and religious traditions in NYC determines not only what Latino groups have access to particular plants and herbs, but also their novel forms of preparation and use.
Viladrich’s talk will also address what herbs and plants are used most often for a) healthrelated purposes, b) teleological aims (e.g., changes in destiny and life-paths), and c) magical-religious purposes (e.g., preparation of omieros as in Santeria ceremonies). Rather than being categorized as discrete categories, products sold by botánicas reveal a poly-functionality which—depending on their specific preparation and combination—are able to impact the physical, spiritual, and religious realms for the purpose of reestablishing a balance in people’s lives. Finally, the piece highlights the importance of developing holistic and multi-level conceptual models able to address Latinos’ elaborated etiologies of health and disease.

Biography

Viladrich’s vast research on alternative healing systems spans more than fifteen years. She has published extensively on Latinos’ folk healing practices, particularly in the United States. Viladrich is currently a Full Professor in the Department of Sociology (with a courtesy appointment in Anthropology) at Queens College, City University of New York (CUNY). She is also affiliated with the CUNY School of Public Health. A native of Argentina, she has a degree in Sociology (BA/MA) from the University of Buenos Aires, Argentina, an MA in Sociology from the New School University, and an MPH and PhD in Sociomedical Sciences (Medical Anthropology), from Columbia University (awarded with Distinction & the Marisa de Castro Benton Award).

Speaker
Anahí Viladrich / Queens College of the City University of New York
USA

Abstract

Although preclinical evidence suggest the protective potential of dietary supplementation with antioxidants, experimental studies in vitro have been rarely conducted to verify the actual efficacy and safety of their combinations. We have investigated the antioxidant/antineoplastic efficacy, as well as the anti-aging activity of a dietary supplement constituted by sulforaphane (SFN), a sulfur-isothiocyanate naturally present at high levels in broccoli, combined with the patented extract Fernblock-XP (FB), obtained from a tropical fern. We studied the effect of SFN and FB, alone or in combination, on migration ability, production of matrix metalloproteinases (MMP) involved in cell invasion, neoangiogenetic potential and activation of inflammasome pathway in human WM115 and WM266-4 melanoma cells. The effect of SFN and FB on MMP and IL-1β production, as well as on the production of reactive oxygen species (ROS), was also studied in human normal keratinocytes. The combination SFN/FB inhibited melanoma cell migration in vitro, MMP-1, -2, -3, and -9 production, as well as inflammasome activation and IL-1β production, more efficiently than each single compound alone. In normal keratinocytes, SFN/FB inhibited the production of both MMP-1 and MMP-3, as well as that of the pro-inflammatory cytokine IL-1β. The inhibition was higher than that obtained with SFN or FB administered alone, both in basal conditions and in the presence of a pro-inflammatory stimulus (TNF-α). These data suggest a potential use of supplements containing SFN/FB combinations both for the prevention of skin aging, and for an adjuvant use in advanced melanoma treatment.

Biography

Simona Serini is currently an Assistant Professor at the Catholic University of Sacred Heart, School of Medicine, Rome, Italy. She received a Post-graduate Diploma (Specialty) in “Clinical Pathology” in 2004, and a PhD degree in “Integrated Oncology” in 2009 at Catholic University. In addition to research, Serini teaches General Pathology and Physiopathology in different courses of the School of Medicine, Catholic University of Sacred Heart, Rome [Degree in Medicine and Surgery (in Italian language and in English language), Degrees in Nursing Sciences, Physiotherapy]. Serini’s professional interests are in the area of neoplastic and inflammatory disease research, with particular attention to the molecular bases of cancer and to the role of nutrition and natural antioxidants in the prevention/therapy of cancer. Serini has authored and co-authored over 50 publications in peer-reviewed international journals.

Speaker
Simona Serini / Catholic University of the Sacred Heart
Italy

Abstract

After being involved in a Traumatic Motor Vehicle Accident and Medicated Pharmacologically within 1 Year I developed and was treated for Fibromyalgia and Chronic Fatigue Syndrome. After 10 Years of Pharmacological Treatment I saw a dramatic decline rather than an Improvement to the Normal Human Functionality which I was previously accustomed to in my everyday Life.
Along with Chronic Pain when introduced to a Cool Damp Climate would trigger extremely painful Fiber Flares where I found that applying Heat Therapy would quickly remedy this Flares rather than waiting for Medications to take Effect. I went on to research Methods to introduce heat to the Hypoxic Myofacial Trigger Point areas designated with Fibromyalgia. I then went on to Patent a Utility Design utilizing Far Infrared Ray Fabric infused with Copper to resonate Heat to these effected Areas. I had a Prototype created in the form of a Vest utilizing Nanotech Far Infrared Ray Fabric. Current Far Infrared Ray Therapies are not only currently unexplored but also are not promoted and are actually discouraged and not made available for inexpensive Holistic means of detox and healing cellular communication and microcirculatory oxygen delivery with can help heal at a vibratory cellular Level in many Capacities.
In further Research I have discovered a plethora of conventional Diseases and Conditions that can be healed utilizing various forms of Organic Biophtotonic and other Light Energy Healing Methods and Modalities.
In Conclusion although Biophotonic Energy and the published Research is new, virtually unknown and not widely put into practical Application new Discoveries into the Ancient Methods are being brought forward and will prove astonishing Results as we head into the Future of Traditional Alternative Healing for Humanity.

Biography

Cathryn Turley is a Technical Analyst and a Consultant for prominent Leaders of National and Global Influence with a Zeal for Social and Humanitarian Wellness. Through her Research she has discovered how Ancient Methods of Healing and Spiritual Practices can heal Modern Humanity and allow us to move forward in the New Paradigm on our Planet. Her current Field of Study Biophotonic Energy and its healing Effects within our Human Body, our Mind and Spirit is a revolutionary recent Discovery and one of the exciting new Avenues for Wellness and Healing as we move into the Future. She has found we can utilize Properties that have been provided to us by our natural Earthy and Universal Elements. The Sun, our Earth and the Cosmic Energies that surround Us. Let there be Light!

Speaker
Cathryn Turley / LivingWell Naturally
USA

Abstract

The etiology of TMD is still consideThe temporomandibular joint (TMJ) is the joint which moves most in our body as compared to other joints. It is a bilateral articulation and when mandibula moves, both joints are moving at the same time. This joint movements depend on the changing positions of our body, changing positions of our head, speaking, swallowing, chewing, etc. The disorder of TMJ can cause pain in jaw and in the muscles which control jaw movement. The pain and the functional restrictions of the movements of the lower jaw are known with several names as Temporomandibular Disorders, Temporo Cranial – Cervical Syndrome , TMJ, etc. The pain is not only myofascial but it can be associated with cervical pain, bursitis, ear pain and some secondary disorders such as sleep disorders , secondary depression and migrena type of headache.
red to be idiopathic but gnatologists believe that dysfunctions of TMJ and also muscles that are inserted on the temporomandibular joint may be the cause of this disorder. There are also other causes of TMJ disoder such as injury to jaw, injury to the joint, injury to the muscles of head and neck, grinding or clenching teeth , TMJ disc displacements in various directions, arthritis of joints also stress which can cause tightening of facial and jaw muscles or clenching of teeth. Chronic pain caused by TMJ disorder has an enormous negative impact in the quality of life of patients suffering from this disorder. This presantation aims at evaluating the crucial importance of acupuncture in the protocol treatment for all the symptoms of TMJ disorder and TMD.

Biography

Suela Baruti is a doctor from Tirana, Albania.She holds a Bachelor degree in Western Medicine from Tirana Medical University and also a Master degree in Traditional Chinese Medicine(Acupuncture, Moxibustion and Tuina) from Shanghai University of Traditional Chinese Medicine.After finishing her Master's academic program she studied at Shanghai Institute of Acupuncture Research and Meridian completing her clinical practice with 1920 hours in acupuncture , moxibustion and tuina ..Suela studied herbs at Long Hua Hospital for 6 months completing her clinical practice with 620 hours .

Speaker
Suela Baruti / Owner acupuncture clinic
Albania

Abstract

Pulse diagnosis is a unique method in Chinese Medicine. More than two thousand years, it has always been the core diagnostic method recorded in the classics such as Huangdi Neijing (Yellow Empero’s Canon Internal Medicine), Nanjing (Classic on Medical Problems) and Shang Han Za Bing Lun. (Treatise on Febrile and Miscellaneous Diseases). However, the theory of pulse diagnosis in Chinese medicine is unable to be well explained in modern hemodynamics.
In 1991, our research team found that the phenomenon of resonance in the arteries which has always been missing in current dynamics. Subsequently in 1997, we derived a radial resonance equation to describe the property of the blood pressure wave propagating and transmitting in the arteries. From the resonance theory and the results obtained from both animal and clinical experiments, we verified the one-coin two sides aspects of the pulse diagnostic method and devised a pulse apparatus according to this principle.
Through the pulse diagnostic apparatus, we could quantitatively analyze the patient pathological excess or deficiency of the meridians and five zang-organs and six fu organs (pathological matrix). In addition, a series of pharmacology research analyses of acupuncture, Chinese herbs, herbs prescription formula and western medicine on the reinforcing or reducing effect of meridians were being carried out. Meanwhile, with matrix operation, we were able to simulate the whole make up function of several herbs in a prescription formula (pharmacological matrix).
In clinic, we found that the pathological indicator in pulse diagnostic apparatus-H.C.V. (Coefficient of Variations of Harmonics Magnitude) could quantitatively show the severity of diseases and evaluate the outcome of patients after treatment. Combined the pathological and pharmacological reverse pair matrixes, we could develop an AI system to identify the indication of the prescription formulae recorded in Shang Han Za Bing Lun, such as the white tiger and green dragon formula. The scientific study of the basic Chinese medicine is the basis of the integrative medicine.

Biography

Speaker
Yu-Cheng Kuo / Taipei Medical University
Taiwan

Abstract

Angelica sinensis, a well-known traditional Chinese herb, is widely used for relieving gynecological discomforts among women population. However, its hormone-like effects have raised great concern on whether it is appropriate to use in breast cancer patients. In this study, in vitro actions of Angelica sinensis extract were investigated on MCF-7 (estrogen receptor-positive) and MDA-MB-231 (estrogen receptor-negative) breast cancer cell lines. It was observed that Angelica sinensis could significantly promote cancer cell proliferation on MCF-7, while inhibit cell growth on MDA-MB-231. Angelica sinensis induced the expression of ERα, which plays a critical role in breast cancer progression. In in vivo studies, Angelica sinensis significantly induced MCF-7 xenograft tumor growth at 2.5 mg/kg without losing body weight. Furthermore, Tamoxifen significantly suppressed the Angelica sinensis-induced MCF-7 xenograft tumor growth in nude mice. Taken together, this study suggests that Angelica sinensis shows potential effect on estrogen receptor-positive breast cancer growth, which should raise special cautions when it is used on breast cancer patients.

Biography

Jianping Chen is a Chinese medicine doctor on Breast cancer and a breast cancer researcher. She Received the Chinese medicine and clinical herbs PhD from Chengdu University of TCM in 1996. From 2002-present she is Assistant Prof and Associate Prof, School of Chinese Medicine, The University of Hong Kong, and honor, visiting Prof. of SYSU, Chengdu University of Traditional Chinese Medicine. Her research fescues on the mechanism of Chinese medicine treatment breast cancer. Her team has developed stratagem for breast cancer, including new drug from Chinese medicine (herb), nano-Chinese medicine and ameliorating chemotherapy-induced toxicity by TCM and food. She has published over 163 research articles, review articles, 15 book and chapters. As principal investigator and co-investigator, Dr. Chen has been awarded grants in cancer and Chinese medicine by GRF, HHRF, ITF, Guangxi science and Technology Department, Fund for international collaboration (AB16450008,RMB27,000,00),NSFC, TDG and so on. She has been reviewing grant applications for many agencies including NSFC, MSFC etc. In 2017 She received Science & Technology Award from Chinese Association of the Integration of Traditional and Western Medicine

Speaker
Jianping Chen / University of Hong Kong
Hong Kong

Abstract

Our study aimed to determine whether a combination of Chinese herbs and acupuncture might affect sperm characteristics. The study group consisted on 12 patients, who failed to conceive in at least 3 previous intracytoplasmic sperm injection (ICSI) attempts. Couples were diagnosed according to the "8 principles" of the Chinese Medicine. Administration of herbs and acupuncture treatments, were given accordingly. Sperm analyses of each patient were compared before and during the treatment. Outcomes were compared with sperm characteristics of 19 patients of the control group, who underwent 2 sperm analyses during 4 months period of time. A higher rate of normal sperm morphology was noticed in the study group after a mean of 39.58+9.3 days of treatment using a paired T-Test (14.17%+6.4 vs 26.58%+11.7, respectively; t11=-3.365, p<.006. No change was noticed in the rate of normal forms in the control group (21.9%+10.4 vs 25.26% +10.29). A difference was also noticed in the volume of the ejaculate after treatment (1.5+ 0.56 vs 2.08+1.16 ml; t11=-2.184 p<0.05). Additionally, 6 pregnancies were achieved following our combined Chinese treatment with ART, 5 of which resulted in successful deliveries, 1still ongoing and one ectopic. We concluded that a combination of acupuncture and Chinese herbs may be a useful, supporting treatment for males and couples who failed to conceive in IVF, and intend to undergo further fertility treatments.

Biography

Tal Bello completed his Master of Oriental Medicine at Maryland Institute of Traditional Chinese Medicine and Advanced Studies at Changdu University of Traditional Chinese Medicine, China & Han Zhu Hospital China. He has published a Book “Undisturbed Journey \ Psychiatry and the mind in Chinese medicine” and many articles & papers. He is Co-founder of “Iyar Herbals” and Practice Acupuncture and Traditional Chinese Medicine in Tel Aviv, Israel.

Speaker
Tal Bello / Seminar Ha' kibbutzim College of Education \ Iyar Herblas
Israel

Abstract

The traditional strategy to reduce chronic oxidative stress is based on the supplementation with antioxidants such as vitamins, flavonoids and thiol containing compounds. However, it has been proposed that in aging, it is far more effective to actively increase the endogenous antioxidant capacity than flood the body with exogenous antioxidants. It is over 40 years in which deep investigation on the effects of use of the ozonated autohemotherapy (O3-AHT) have been conducted particularly thanks to Prof. V. Bocci and his team in Italy. Clinical findings have shown how the biological messengers derived by this treatment as ROS (Reactive Oxygen Species) and LOP (Lipid Oxydation Products), are delivered to the cytoplasm causing the release of the transcriptional factor Nrf2. Then this one is translocated to the nucleus and it binds to the Antioxidant Response Element (ARE) on DNA, thus allowing the up-regulation of the transcription of about 230 genes of antioxidants such as SOD, catalase (CAT), GSH reductase (GSH-R), GSH peroxidase (GSH-Px), HEME -Oxigenese-1, heat shock protein 7 (HSP70), phase II enzymes. Moreover it stimulates GSH regeneration via gamma-glutamylcysteine-synthetase, glutathione- and thioredoxin-reductase thus enhancing the GSH level (Ozone: A multifaceted Molecule with Unexpected Therapeutic Activity – Zanardi et Al).
Ozone oxidative preconditioning (O3-OP) can achieve this target via generating a number of messengers that can reach all the cells of the body and act to reverse the age-related chronic oxidative stress by readjusting the altered cellular redox balance.
In order to get these effects the ozonated autohemotherapy (O3-AHT)) as elective bio-oxidative pre-conditioning is the procedure that could be part of an integrated approach within preventative and personalized medicine protocols in the set – up of antiaging and wellness clinics.

Biography

Claudio Tavera since he was completing his MD degree in Italy, started to focus his interest on topics of Applied Human Physiology such as neurophysiology, physical exercise and nutrition. In 2004 he got the post medical degree specialty in Sport Medicine. Furthermore he investigated the pillars of Antiaging and Regenerative Medicine throught the certification training attended in USA with the A4M (ABAARM). Since about ten years he is working in famous Wellness Clinics in Italy and abroad targeted on holistic approach for body detoxification, weight-loss and stress management. He is involved in the activity of Italian Scientific Associations of Ozonetherapy.

Speaker
Claudio Tavera / MWS, Sport medicine specialist
Italy

Abstract

Traditional medicine, occasionally called alternative medicine or complementary medicine, is presently experiencing significant development in Algeria. In the health care markets, several practice categories are being expressed in the name of traditional medicine and prophetic medicine. These practices, known as «Rokya» and «Hijâma», are developing as a very fruitful business in Algeria. Many herbalists providing medical care, «Achchab» in Arabic, are appearing more prominently in the marketplaces. Arab Muslim medicine remains alive in the contemporary practices of traditional medicine. This review reflects an interest in the medicinal plant species and other material cited in the sacred texts and used currently in traditional medicine in Algeria. The use of several traditional medicine indications have been supported on the basis of their safety and efficacy. This review analyzes the importance of these practices between popular and religious beliefs. Proposals were made for the development of the traditional medicine in Algeria based on the recommendations of the World Health Organization (WHO).

Biography

Speaker
Amel Bouzabata / University Badji-Mokhtar
Algeria

Abstract

Chemotherapy is an important treatment option for cancers. However, chemotherapeutic agents have poor selectivity on cancer cells, likely causing damage to healthy cells. Squamous cell carcinoma (SCC) is a common tumor of head and neck with a high morbidity and mortality. In clinical settings, traditional Chinese medicine (TCM) has been employed to treat SCC. TCM is associated with fewer side effects than conventional chemotherapy agents. Hedyotis diffusa is a traditional Chinese herbal medicine and widely distributed throughout Northeast Asia. It exhibits many biological activities such as anticancer, anti-oxidative, anti-inflammatory, and neuroprotective effects. However, the anticancer potential of HDP in laryngeal squamous cell carcinoma has not been determined. The aim of this study is to explore the anti-tumor potential of Hedyotis diffusa polysaccharides(HDP) in human larynx squamous carcinoma. High performance size-exclusion chromatography analysis indicated the homogeneous nature of HDP. Total carbohydrate content in HDP was 97.3%, without contamination of protein and nucleic acid. HDP suppressed the proliferation of Hep2 human larynx squamous carcinoma cells in a time- and dose-dependent manner. Cell cycle analysis revealed that exposure to HDP (400 μg/mL) caused a G0/G1 cell cycle arrest. Moreover, treatment with HDP for 24h induced a significant apoptosis of Hep2 cells, which was accompanied by increased cleavage of caspase-3, caspase-8, and caspase-9 and reduced expression of Bcl-2 protein. Additionally, HDP inhibited cell migration and suppressed the expression of MMP-2 and μPA. HDP shows suppressive effects against the aggressive phenotypes of human larynx squamous carcinoma cells and may have therapeutic potential for this malignancy.

Biography

Zhenghui Wang has completed his PhD at the age of 32 years from Xi’an Jiaotong University and research fellow studies from Beth Israel Deaconess Medical Center of Harvard University. He is the Member of the Asia Pacific Plastic Surgery Committee. He has published more than 70 papers in reputed journals and has been serving as an editorial board member of seven international journals. Meanwhile he served as reviewer of many reputed journals . He has got many rewards in China and many funds from China government.

Speaker
Zhenghui Wang / Xi’an Jiaotong University
China

Abstract

Rationale. The acute coronary syndrome (ACS) included several situations where blood supply to the heart undergoes a sudden interruption. Electrocardiographic evaluation and analysis of serial blood samples to determine cardiac troponin I and T (cTnI, cTnT), CKMB, and myoglobin are used to diagnosis. The cTnI is the top of these indicators. Whereas necrotic cardiac muscle cells release these molecules, the earliest biomarkers are those who are now receiving more attention. Extracellular nanovesicles (ECNVs), also called exosomes, have acid nucleic molecules, proteins, and lipids as a cargo. Current paradigm concludes that exosomes act in cell to cell communication, so exosomes are produced by living cells, before necrosis state, allowing the exosomes could be detected before than plasmatic Troponin.
Objective. Main objective of this study is to quantify the plasmatic exosomes concentration present in an enriched fraction of extracellular nanovesicles (ECNV) and compare it with cTnI in ACS patients.
Methods. Plasma were obtained from emergency room (ER) patients. They were diagnosed as ACS and Control (without ACS). Plasma were filtrated (0,22μm) and the ECNV were analyzed by Nano-Tracking Analysis, to establish its association with ACS patients. We compared timing of cTnI and NVECs plasma concentration during 24hrs of observation.
Results, and Conclusions. The plasma concentration of total ECNV increased significantly in patients with ACS during the 24hours. The nanovesicles from 30-100 nm had plasma average concentration 14-fold higher than control patients during the 2 hours of hospital admission, and cTnI was later. The risk factors of ACS (DM2, HTA, dyslipidemia, age, or gender) did not contribute to plasma ECNV concentration. The in vitro hypoxia to primary cardiomyocyte cell cultures induced the ECNV from 15 minutes. The earlier elevation of plasmatic NVECs (2hrs) that cTnI suggests an opportunity window for therapy for better management of myocardial infarction.

Biography

Speaker
Carlos Irarrazabal / Universidad de los Andes
Chile

Abstract

Besides the numerous research and development in the conventional medicine to encounter severe diseases, most of people in the world population still practice the traditional medicine as one of the alternative and complementary treatment. Combinations of certain compound from the traditional medicines is a common recipe for the formulation. This combination may have an interaction between these compounds thus the safety dose or its toxicity should be measured. In the current study, the combination of Trigona itama honey, Nigella sativa oil and zamzam water were tested in the healthy male rats with dose administered according to the OECD 420 protocol with some modification to explore their suitable doses for pharmacological screening. The doses administered were 50mg/kg, 300mg/kg, 1250mg/kg, 2000mg/kg, 2500mg/kg and 5000mg/kg. Observation were made immediately and the results show no sign of toxicity in the parameters observed. In addition, there are no mortality recorded at the first ½ h, 1h, 4h, 24h and 48 hours regardless the doses administered. This conclude that the combination of Trigona itama honey, Nigella sativa oil and zamzam water is highly non-toxic even at high dose, 5000mg/kg.

Biography

Speaker
Nasir Mohamad / Universiti Sultan Zainal Abidin
Malaysia

Sessions:

Scientific Sessions

Abstract

BACKGROUND:
The problem of treating and rehabilitation of trauma pathology is very urgent. But there is a lack of rehabilitation programs providing complex application of medical therapy, including traditional Chinese medicine methods (TCM). It is known that acupuncture may improve neuromotor apparatus and help manage chronic pain associated with injuries.
OBJECTIVE:
Develop the scheme and bring out significance of complex approach in patients with trauma and in patients with trauma during post-surgery period. The aim is to decrease the intensity of long-term pain, and to improve the movement range of the injured limb by means of TCM.
METHOD:
25 patients took part in this research and treatment. They were divided into two groups: the first group consisted of 10 patients with arm trauma without operative intervention who had taken medical treatment in different health facilities; the second group consisted of 15 patients where all of them had undertaken operative intervention for treating trauma. A vast variety of TCM methods had been applied to treat patients of both groups including corporal and auricular acupuncture, moxibustion, Gua-Sha method, cupping, etc. MRI, CT, Electromyography, Ultrasonography and other modern methods of diagnostics had been applied before and after treatment in order to assess the efficacy of TCM complex therapy.
RESULTS:
After the treatment no complaints were recorded in patients of both groups. Movement range in the injured limbs had been restored to the fullest extent, adduction and flexion rates of the injured arms had significantly improved.
CONCLUSIONS:
The use of TCM methods as complex therapy to treat trauma seems to be a safe and reliable technique to achieve clinically significant results and could be applied as complementary therapy.

Biography

Lili Luzina-Chju completed her Ph.D. in Medical Practice at the First University of Medicine in Alma-Ata. She went on to defend her thesis on Biliary tract Dysfunction Treating with Acupuncture in Moscow and to have 200 publications, among them articles, abstracts; two tutorials; two monographies “Acupunture for some skin diseases”, “Complex reflexotherapy for the patients suffering from thyroid diseases” “The Basics of the Traditional Chinese Medicine”, 2009, 660 pages, ISBN 5-225-03395-4. She has 20 years of professional experience in acupuncture. Lili Luzina-Chju has been a member of the Moscow Association of cardiologists since 1991. She is Curator of Charity Boarding School for Children suffering from Cerebral Palsy for 15 years.

Speaker
Lili Luzina-Chju / Sin-Ya-Chju TCM Center
Russian Federation

Abstract

Objective: To evaluate, among women receiving chemotherapy for breast cancer, the efficacy of the Bali yoga program (BYP-BC) on their quality of life (QL) using an instrument based on life objectives instead of a health related QoL instrument (HRQL).
Method: 101 breast cancer women (BC) (stage 1-3) were randomly assigned to experimental (BYP-BC: n = 58) and control (waiting list: n = 43) groups. The BYP-BC started at onset of chemotherapy and lasted eight weeks. The control group received standard care for eight weeks before beginning the BYP-BC.
Measurements: Quality of life systemic inventory based on life goals measuring the gap between the patient’s condition and her goals in 28 life domains. Results: the two groups were compared with a groupXtime anova. The global score, the affective and physical health subscale scores improved (p = 0.001, p = 0.017, p = 0.008) in the BYP-BC group but not in the control group. The cognitive subscale score improved (trend) in the BYP-BC (p=0.068) and deteriorated in the control group (p=0.017). At post-test, the BYP-BC group showed a trend for better global and affective scores and a significant better cognitive score than the control group (p = 0.09, p=.085, p=.028). No significant results were obtained regarding the other subscales.
Conclusion: A measure of QL based on the capacity to reach one’s life goals is sensitive to the efficacy of the BYP-BC during chemotherapy. This type of tool is more holistic than HRQL tools which do not consider patients’ life goals and priorities.

Biography

Gilles Dupuis is a full professor in the Department of Psychology at the University of Quebec in Montreal (UQAM) since 1989. He is author of the Quality of life Systemic Inventory (QLSI©: www.qualitedevie.lepsyq.ca/fr), an instrument that allows to evaluate quality of life in different clinical settings, based on life priorities and goals attainment. He is specialized in statistics and health psychology. He gives doctoral seminars on yoga for physical and psychological health problems, teaches yoga to doctoral students and does research in this area. He is also a yoga professor since 12 years.

Speaker
Gilles Dupuis / University of Quebec in Montreal (UQAM)
Canada

Abstract

Health is an important aspect of life for all peoples. However, Canadian Indigenous cultural understandings of health and healing are distinctly different from biomedical understandings that have prevailed in most health care provider and research settings. These paradigm differences can form a barrier to effective health research and care for Indigenous peoples who seek services from biomedical professionals, including those who may be trained in cross-cultural sensitivity. Further, some experts (see Gone, Kirmayer, Stewart) suggest that treating Indigenous individual exclusively from non- Indigenous perspectives (i.e., biomedical perspective) is a form of continued oppression and colonization, as it does not legitimize the Indigenous paradigms of health and healing. The presentation shares results from a national study on Indigenous knowledges and health research ethics, in which 300 Canadian researchers in Indigenous health were surveyed about the role of traditional Indigenous knowledges in health research, ethics, and methodologies. Results include significance in terms of culturally safe and ethical practices in health research and implications regarding policy, training, and service for both researchers and healthcare service providers who use evidence based practices.

Biography

Suzanne Lea Stewart is a member of the Yellowknife Dene First Nation. She is a registered clinical psychologist and Associate Professor of Indigenous healing in Counseling Psychology at OISE/University of Toronto, where she is Special Advisor to the Dean on Aboriginal Education and Interim Director of the Indigenous Education Initiative. Research and teaching interests include Indigenous mental health and healing in psychology (homelessness, youth mental health, identity, and work-life development), Indigenous pedagogies in teacher education and higher education and psychotherapy practice/training. She is also Chair of the Aboriginal Section of the Canadian Psychology Association and is committed to advancing Indigenous healing issues through the discipline of psychology, and currently serves as the Acting Director of the Community Development Collaborative Program.

Speaker
Suzanne Lea Stewart / University of Toronto/ Waakibeness Bryce Institute for Indigenous Health
Canada

Abstract

Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD) are medical diagnoses classified under the Neuro-developmental Category of the Diagnostic and Statistical Manual of Mental Disorders (DSM-V). Literature has indicated a high percentage of comorbidity between SLD and DCD. Unfortunately, although 6-15% of the population confronting with SLD/DCD, this hidden phenomenon is largely unknown and misdiagnosed among physicians and the general public. The study aimed to find unique personal, health, body and daily function characteristics of adults diagnosed with SLD and DCD in comparison to those of controls. Participants were 60 adults aged 21 to 50. Thirty adults diagnosed with SLD and DCD and 30 controls matched for age, gender, socio-economic-status and years of education volunteered for the study. Participants completed the following questionnaires: (a) demographic and health questionnaire (b) Body function - Behavioral Rating Inventory of Executive Functions (BRIEF-A) (c) Activity and Participation - Time Organization and Participation (TOPS) and) d( Life quality - World Health Organization Quality Of Life questionnaire (WHOQOL-BREF). Results indicated that adults with SLD/DCD have unique characteristics concerning personal factors, health, body functions and activity performance. In addition, specific executive functions and time organization abilities predicted over 54% of the variance in their psychological life quality. This may partially explain the difficulties they experience in daily function and influence their life quality. The implications of these results to future theoretical and clinical developments for this population will be discussed.

Biography

Kineret Sharfi holds a PhD degree in Occupational Therapy and is an Occupational Therapist, expert in child development and daily functioning with learning disabilities and AD/HD across the life span. Sharfi is the owner and manager as well as a therapist in her private Clinique and a lecturer in Kaye educational college, Beer-Sheva.
Sara Rosenblum is a Professor, Head the Laboratory for the study of Complex Human Activity and Participation, with special interest in the characteristics of human daily function. Rosenblum aim to gain better insight into interactions between varied body functions (e.g., cognitive, motor, sensory), activity performance and participation abilities of people faced with functional deficits in everyday life.

Speaker
Kineret Sharfi / University of Haifa
Israel

Abstract

In recent years there has been a lot of talk about PNEI (Psycho Neuro Endocrino Immunology), reflecting on the wide range that this approach could have on the treatment of our patients. In fact, the PNEI is basically a change of perspective; to use a subphrases that will be appreciated by physics lovers, it is a different reference system. Knowledge slowly tends to increase, but in this case it is essentially the change of perspective that makes the difference. However, it is very complicated to have an overview of the pathophysiological dynamics of the patient, and as the specialization of the Professional increases this goal becomes even more complicated to achieve.
An acronym has been created that encompasses many areas together, but in fact there is little collaboration between the areas of competence. We believe that this happens because hyper-specialization has made the overall vision of the specialist less acute, making him short-sighted to the totality, and therefore less able to make connections and seek support, confirmations and comparisons with other professionals from different areas. On the contrary, we believe that the figure that should be at the centre of the PNEI interpretation scheme should be the Osteopath, both for his theoretical training and for his deep-rooted interpretation of the patient as a unitary body.
Today there are prerequisites for talking about PNEI-O Psycho Neuro Endocrino Immunology – Ostheopathy.
This is due to both: the formation of osteopaths and the pathophysiology of the most common disorders of patients.
In addition, there is a perfect example that best demonstrates the conviction of the role of the osteopath in the multidisciplinary team: inflammation - the PNEI process par excellence.

Biography

Paolo Flocco is a Physiotherapist graduated from the University of Rome "La Sapienza" with the highest marks. After various work experiences and different courses, he enrolled at CERDO, one of the most prestigious schools of Osteopathy in Italy, and after six years of training he became Osteopath D. O. For several years he has been working as a professional and dealing with study and research. He writes in national journals and blogs of scientific popularization. He is also a lecturer and member of the scientific committee of the most important post-graduate training company for physiotherapists in Italy. He is the founder of MAIT, a new approach to manual medicine that is about to face the global panorama.

Speaker
Paolo Flocco / MAIT
Italy

Abstract

The traditional Chinese medicine Niubeixiaohe (NBXH) is an effective anti-tuberculosis (TB) experience of prescription, which is made up of Bulbus Fritillariae Cirrhosae, Rhizoma Bletillae, Radix Platycodonis, Fructus Arctii, Herba Houttuyniae and Glutinous rice. Evaluation of clinical efficacy of NBXH prescription in the treatment of TB showed that the cure rate was 55.42% (46/83), obviously effective rate was 34.94% (29/83), effective rate was 7.23% (6/83), 2.41% (2/83) were invalid, the total effective rate was 97.59%. At 28 days after the culture, 1mg/ml NBXH extract could significantly inhibit the growth of MTB H37Rv compared to the negative control. Compared with the negative control, the proteome of MTB H37Rv in NBXH extract had 142 different protein spots, and in the INH group had 147 differential protein spots, there were total 149 different protein spots. Of 71 protein spots analyzed by mass spectrometry, 41 high confidence proteins were identified, in which 35 (7 up-regulated, 28 down-regulated) in the INH group and 39 (5 up-regulated, 34 down-regulated) in the NBXH extract group were identified, there were 33 same different proteins in these two groups. By analyzing of their biological functions, we found that NBXH extract could reduce the viability of MTB in macrophages by inhibiting the protein synthesis, energy metabolism and antioxidant stress of MTB, affect the latent infection of MTB, thus play anti-tuberculosis effect.

Biography

Xueqiong Wu is currently working as a researcher, Professor and vice head at the Army Tuberculosis Prevention and Control Key Laboratory, Institute of Tuberculosis Research, the 309th Hospital of Chinese PLA, Beijing 100091, China. Xueqiong Wu received her Doctoral degree on Chinese PLA Postgraduate Medical School, Masters degree on the Academy of Military Medical Science. She has authored many publications in various journals and books. Her publications reflect his research interests in tuberculosis. Dr. Wu is also an Associate Editor of Chinese Journal of Anti-tuberculosis. She is currently in charge of ongoing project on M. tuberculosis DNA vaccine.

Speaker
Xueqiong Wu / Institute of Tuberculosis Research, the 309th Hospital of Chinese PLA
China

Abstract

Medicinal plants are widely used against diabetes throughout the world and as well as in Pakistan. But, few of them have validated for scientific criteria, great diversity of animal models are being introduced to better understand the pathogenesis and new drug effects of diabetes. Diabetes mellitus is rapidly growing at an alarming rate. The attention is focussed to work on previously unexplored medicinal plants (such as Boerhavia procumbens, Corchorus depressus, and Farsetia hamiltonii) extracts from Choilstan Desert of region Bahawalpur in a standard scientific and systematic way. These medicinal plants are being traditionally used to cure devastating diabetes mellitus. The crude extracts would be subjected to a screening study to detect potential anti-diabetic activity.
Our experimental strategy involves collection of medicinal plants from the Cholistan Desert of Bahawalpur in different season. Consequently, chemical fingerprinting (bioassay-guided extraction, fractionation, purification and structural characterization of lead compounds through modern spectroscopic techniques) and biological fingerprinting (DNA-target analysis, HSA binding, or liposome-binding chromatography) have been under taken. Finally, studies also include toxicological profiling; followed by pre-clinical trials to cure diabetes in alloxan/streptozotocin induced diabetic rats.

Biography

Shazia Anjum is the Professor of the Chemistry Department and the Director of Cholistan Institute of Desert Studies, the Islamia University of Bahawalpur, Pakistan. Recently, she has been elected a Fellow of The Islamic World Academy of Sciences. She is experienced medicinal and natural product chemist. She has authored and co-authored more than 100 research papers, a US patent, has edited 08 books and has published 02 chapters in international books. She has accomplished the synthesis of several naturally occurring aminoglycosides- that can be used as antibiotics. As recognition of her contributions to science she has been awarded with 2 International awards from Ministry of Culture and Education, Spain and Third World Academy of Sciences Young Chemist Award, Italy. She is also recipient of several national awards.

Speaker
Shazia Anjum / The Islamia University of Bahawalpur
Pakistan

Abstract

The study was designed to evaluate the effects of Bombys batryticatus ethanol extract (BBE) on the viability and apoptosis of human hepatoma cell line (SMMC-7721) and to investigate its molecular mechanism. LC-MS was used to detect the related substances of BBE. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, morphological assessment, DNA fragmentation assay, flow cytometry analysis, western blot analysis and real time -PCR analyses were used to investigate the anticancer activity of BBE. BBE induced the SMMC-7721 cells apoptosis in a dose- and time-dependent manner. IC50 for the BBE was 0.1812mg/ml when the cells were treated for 30h. Annexin-V/PI double-staining assay identified early and late apoptosis morphology. A typical cell apoptosis with increased DNA fragments was found in BBE treated cells. Transcription and expression levels of Bax and P21 were increased whereas the synthesis of Bcl-2 was decreased. The results suggested BBE has strong anticancer activity in SMMC-7721 cells and provides a solid molecular base for developing new cancer treatment compounds from a natural insect product.

Biography

Wang is a Professor in Institute of Entomology in Northwest A&F University (NAFU). He completed his Ph.D in Entomology from Zhejiang University in 2005. Wang is Director for the Lab of Insect Related Resource at NAFU. He is a committee member of Insect Biochemistry and Molecular Biology in the Entomological Society of China and a committee member of Young Scientist Branch in Chinese Forestry Society and the committee member of Young Scientist Branch in Chinese Society of Plant Protection. He was granted as New Century Excellent Talent from Ministry of Education in China in 2006. Wang has the active research projects in the areas of insect biochemistry and molecular biology, biomaterials, molecular pharmacology for insect herbals. In addition to overall scientific responsibility for all projects, Dun is one of the senior investigators on selected core and collaborative projects in the Institute of Entomology in NAFU.

Speaker
Dun WANG / Northwest A&F University
China

Abstract

Indiscriminate use of antibiotics of microbial origin often results in the development of ‘side effects’ and ‘drug resistance’ in disease causing agents. This perception motivated the scientific community towards search for alternate sources for combating the infectious diseases. Consequently, discovery of new antimicrobials of plant origin, as safer source of antibiotics, is increasingly receiving attention. Medicinal plants, in particular, have traditionally played important role in socio-cultural, spiritual and medicinal arena of many societies, since antiquity. A number of tribal communities inhabiting the North-East (NE) region of India have strong knowledge base on the utilization of plants in form of traditional medicinal system.
The present study is based on the documentation of medicinal plants used in traditional medicine by three major tribal communties of NE India. A total of 54 species belogning to 37 families were recorded with Asteraceae being the most dominant (6 species) followed by Ranunculaceae, Solanaceae, Zingiberaceae (3 species each) and others. Different plant parts of these species are applied in treating various ailments including infectious diseases. The study revelead antimicrobial potential of various medicinal plants used in traditional medicine.
The documented traditional knowledge base is going to be an effective tool to support future research on ‘antimicrobials’, preferably in the well established area of ‘phytomedicine’. Prioritization of medicinal plants, based on the traditional knowkedge vis-à-vis the specific phytochemical compounds, is likely to result in the selection of antimicrobials rich plants. Inclusion of advanced technologies such as genomics, proteomics and metabolomics will further enrich this area of research.

Biography

Om Prakash Arya expertises in Chemical and Biochemical Engineering. His primary research involves documentation of medicinal plants and bioactive compounds including antimicrobials. He further specializes in optimization of extraction methods for better recovery of health promoting bioactive contents from medicinal and high value plants of NE India.

Speaker
Om Prakash Arya / G.B. Pant National Institute of Himalayan Environment and Sustainable Development
India

Abstract

The term « cosmetopoeia » refers to plants and their traditional uses for bodycare and well-being in regards to a specific region and its local population, as part of its cultural heritage. Although it remains a newly coined concept, its definition is far more ancient. Rather than a reductive notion, it entails a multidisciplinary approach encompassing a variety of complementary fields such as ethnobotany, biodiversity assessment, ABS (Access to genetic resources and traditional knowledge and Benefit Sharing)… Such compiled data, including the phytochemical content and biological plant properties, highlight their interests in further valuation as natural cosmetic ingredients.
Plants have been used for centuries in Polynesia but also in various parts of the world, to treat skin ailments, prevent hair loss or as perfumes, to name a few properties. Nurturing one’s body is an important practise in French Polynesia where many plant-based treatments and ointments like monoï are still used to beautify skin and hair, for personal care as well as intimate hygiene. We aim to bring a better understanding of the chemistry behind the studied plant biological activities, put together monographs and further highlight cosmetic uses. An ethno-oriented investigation of Polynesian plants listed in the Inventory of Existing Cosmetic Ingredients in China (IECIC 2015) coupled with phytochemical data was helpful to select a dozen plants belonging to genera such as Gardenia, Calophyllum, Adenanthera... The most interesting among them, regarding their cosmetic potential, will be further proposed as candidates for the development of skin and hair care products.

Biography

Kristelle Hughes is currently a PhD student in Natural Products and Phytochemistry at the University of French Polynesia. She is part of Prof Raharivelomanana’s team working on Cosmetopoeia. Her PhD project under Prof. Raharivelomanana and Dr. Ho’s supervision, focuses on plants traditionally used in French Polynesia as cosmetics with an end goal to achieve the development of innovative cosmetic ingredients and products.

Speaker
Kristelle Hughes / University of French Polynesia
French Polynesia

Abstract

The use of extracts from brown desert truffles Terfezia claveryi was already mentioned in Coran and it has a well-established role in traditional medicine of several countries with desert areas. (i.e. Syria, Jordan, Afghanistan). Antibiotic activities were already described from various authors without identifying a molecule responsible. Pleased by results observed in popular medicine it has been started the development of a formulation prepared under standardized conditions aiming to obtain a product to be registered as medicine.
The preparation technique has been kept as simple as possible, standardizing the conditions of pH, osmolarity and purifying the product by ultrafiltration; chemico-physical criteria have been defined for quality control in the future.
Following this stage, toxicity studies have been performed “in vitro” and “in vivo” showing that the product has adequate characteristics to enter clinical studies. At the meantime, microbiological tests have been performed on different bacterial strains to verify the antibacterial activity of this product and its stability in different conditions of storage and handling: the activity profile proved to be interesting and the stability confirmed. As a consequence, a phase I study has been carried-out showing a good ocular tolerance without systemic toxicity. Preliminary PK data have been also obtained to verify the absorption of components coming from the eye drops, excluding systemic absorption.
Following these findings it has been decided to develop further this product and a phase II study is now under preparation to confirm, in a controlled clinical setting, the well-known activity reported in traditional medicine.

Biography

Luigi Silvestro graduated in Medicine in Turin (Italy) in 1984 and specialized in Pharmacology in 1988. From 1989 he is applying HPLC-MS in quantitation of bioanalytical samples as well as identification of drug metabolites. In 1996 he has co-founded 3S-Pharmacological Consultation & Research GmbH, a consultation company and CRO, in Germany and is still actively involved in the development of innovative analytical methods. From 1998 the company has expanded the activity in East Europe (Romania, Moldavia) creating an analytical laboratory in Romania (Bucharest). In his scientific activity he has contributed to more then 60 articles in international scientific journals.

Speaker
Luigi Silvestro / 3S-Pharmacological Consultation & Research GmbH
Germany

Abstract

The concept of aging is deeply connected with inflammation, oxidative stress and matrix acidity. In order to evaluate matrix inflammation, skin parameters such as ph, sebo, elasticity and hydration can be very useful. These parameters reflect also the state of health of the body which is related to lifestyle, environment and genetics. Aging has a lot to do with hormones whose production starts to drop after 35 years of age. Women tend to age prematurly depending on thinner skin, hormonal unbalance and tendency to develop expression lines. Skin inflammation can be handled through systemic interventions as in Pneisystem: antioxidant nutrition, nutraceuticals and anti-stress techniques which globally promote youth and stop aging.

Biography

Maria Corgna completed her Ph.D in Medicine at the University of La Sapienza and Specialization in Endocrinology at the University of Tor Vergata. She extensively investigated Psychoneuroendocrinoimmunology since the year 2000 and created a method of integrated diagnosis and treatment known as Pneisystem. Pneisystem is based on epigenetics and considers therapy the result of 4 main types of intervention: stress management, nutrition, physical exercise and integrated therapies. It also considers Environmental Medicine essential.

Speaker
Maria Concetta Corgna / MD Specialist in Endocrinology – Teacher and Expert of Psychoneuroendocrinoimmunology
Italy

Abstract

Background and Objectives: Citrullus colocynthis is an annual plant, also called bitter apple or bitter cucumber, hairy-stemmed perennial vine of the gourd family (Cucurbitaceae), native to the Mediterranean region. The colocynth grows in sandy, coastal, or desert soils and commonly spreads vegetatively. The plant has small, pale greenish yellow flowers, forked tendrils, and hairy, deeply cut leaves. The rounded yellow or green fruits have a bitter taste and yield a strong purgative sometimes used in medicine. Also it grows in the south, center, and east areas of Iran.
Methods: This study is a review-research article and data collected by investigating the traditional medicine reference books and the findings that are extracted from databases such as Pubmed, Google Scholar and internal academic database.
Results: It is recognized by different pharmacologic activities in traditional Persian medicine; consist of purgative, anti-inflammatory, antidiabetic, analgesic, abortifacient, and antiepileptic. Some of these activities were confirmed in modern phytotherapy.
Conclusion: According to our experiences the Abu Jahl watermelon and Hanzal in Traditional Persian Medicine, they are the same and they match with Citrullus colocynthis. The paper reviewed Citrullus colocynthis in traditional Iranian medicine as a great promise for development of novel drug with the wide range of pharmacological activities, which could be utilized for horrible human disease, because of its effectiveness.

Biography

Mohammad saeed has completed his MD at the age of 25 years from Yazd Shahid Sadoghi University of Medical Sciences, Iran. His thesis was the “prevalence of eye complications of marfan syndrome” with the very good degree. He is the PHD student of Persian medicine of Yazd Shahid Sadoghi University of Medical Sciences, Iran, now. His main research interests are in the traditional medicine, alternative medicine and herbal medicine.

Speaker
Mohammad Saeed Kalantari Meybodi / Yazd Shahid Sadoghi University of Medical Sciences,
Iran

Abstract

Background: Obesity (Samane-e- Mufrat/ Farbahi) has become a serious public health problem now days. Despite tremendous development in the medical science, several diseases are still challenging to human being & efforts are continued to conquer them. Although certain level of weight gain is a good sign of health but if it exceeds normal limit it becomes dangerous. The available synthetic pharmacological therapies have their own side effects and limitations.
Objective: The objective of this study was to explore the obesity & its management with Unani System of Medicine.
Methods: Review of literature was done from Unani Pharmacopeia of India, Bangladesh National Formularies of Unani Medicine, ND Health facts & PubMed, internet data from inception to 01 November, 2017, observational data relating to Unani Medicine and Obesity & its treatment, prevention.
Results:. This paper gives information on herbs and its mechanism of action for weight reduction. Evidence suggests that dietary modification, foods, lifestyle modification also play good role to prevention & control of Obesity.
Conclusions: In light of the results of the present review study, it can be concluded that these information can help our knowledge to enrich us regarding how & which approaches of Unani system of intervention are to use to prevent & control & treatment of Obesity.

Biography

Md. Shahjalal Chowdhury has completed his MPH (Epidemiology) from ASA University Bangladesh, (BUMS or Bachelor of Unani Medicine & Surgery) under the University of Dhaka, Bangladesh. He is the lecturer of Hygiene & Community Medicine, Hakim Said Eastern Medical College & Hospital 37, Nimtoly, Dhaka-1000, Bangladesh, a concern of Hamdard Foundation Bangladesh. He has published more than 15 papers in reputed national journals in Bangladesh.

Speaker
Md Shahjalal Chowdhury / Hakim Said Eastern Medical College & Hospital
Bangladesh

Abstract

The people of mountainous terrains depend on folk therapies to combat their ailments; however the absence of plant based research and geographical constraints set the traditional knowledge on jeopardy. Present study is the first ethnobotanical documentation on medicinal plants of Shigar valley, Karakorum Range, Northern Pakistan along with the drug description and administration. Ethnobotanical data were from 84 respondents using semi structured questionnaire approach. Quantitative indices i.e. relative frequency citation (RFCs) and fidelity level (FL) were calculated to evaluate the importance of medicinal plant species. In total 84 plant species belonging to 36 families and 72 genera were recorded. Fabaceae was dominant family with 7 species, followed by Asteraceae, Lamiaceae and Rosacea (6 species for each). Leaves, root, flowers, seeds and fruits were frequently utilized plant parts, whereas decoction ranked first in drug formulations with a contribution of 49%. Majority of the plant species were documented for abdominal disorders, respiratory disease and dermal problems (31, 12 and 12, respectively). RFCs value was ranged 0.477 to 0.11 for Tanacetum falconeri and Allium carolinianum, respectively; while 100% FL was calculated for Hippophe rhamnoides and Thymus linearis. Comparative assessment revealed that 26% of the reported species such as Hedyserum falconeri, Aconitum violoceum var. weileri, Arnebia guttata, Biebersteinia odora, Clematis alpine var. sibirica, Corydalis adiantifolia and Saussurea simpsoniana were newly reported. Present investigation exposed endemic medicinal plant species and traditional knowledge of Balti community living in extremely high mountains area. However, more work is required; to drive the existing knowledge in market circuit with sustainable collection and to evaluate economic potential of the plant species of the area. Further social livelihood could be strengthen by establishing collection sites, transformation and drying centres for micro and macro marketing of medicinal plant species.

Biography

Arshad Mehmood Abbasi (PhD) is working as Assistant Professor of Environmental Sciences at COMSATS Institute of Information Technology, Abbottabad, Pakistan Since 2013. He received his PhD from Quaid-i-Azam University, Pakistan in 2013. His primary research and professional activities have been in ethnobotany, ethno- medicines, medicinal plants biodiversity, forest food resources, phytochemistry, nutraceuticals and functional foods. He has published a number of research articles in the Journals of international repute on these areas and also author of two books title “Medicinal Plant Biodiversity of Lesser Himalayas-Pakistan” published by Springer, USA in 2012; and Wild Edible Vegetables of Lesser Himalayas: Ethnobotanical and Nutraceutical Aspects (Volume-1) published by Springer, USA in 2014. Abbasi is also the member of editorial board of the: Journal of Ethnobiology and Ethnomedicines and reviewer of many international scientific Journals. He has been awarded “Outstanding research award in best paper category” for the year 2010-2011, in best book category for the year 2012&2015 in 2015 and 2017 by Higher Education Commission Government of Pakistan.

Speaker
Arshad Mehmood / COMSATS
Pakistan

Abstract

The process of food digestion, is one of the most important physiologic processes in human body. In this review article, we are seeking the views of Avicenna, the most distinguished Persian medical scholar about digestion and indigestion. Avicenna’s view was basically based on the humoural theory. Avicenna has focused scrutiny on the process of digestion. He divided this process into four phases including gastric, hepatic, intravascular and intra-organ digestion. A defect in any of these phases can lead to disturbance in other stages. Avicenna approached the problem of indigestion through factors of diet, lifestyle and inherent structural characteristics of digestive organs. Quantity and quality of meals, eating habits and lifestyle parameters such as physical activity, sexual activity, mental situation, sleep and even climate are among the issues that Avicenna considered them in the approach to indigestion. The description of the digestive process and the organs involved in digestion, nutritional recommendations and the key role of proper digestion process in maintaining body health which are explained by Avicenna, have evidence in modern medicine. Given the importance of digestion from the view of Avicenna and support of a large part of its teachings by modern medical findings, it seems rational to consider the medical approaches recommednded by him for future studies in the field of digestive disorders in order to promote public health with safe, affordable and efficacious recommendations.

Biography

Alireza Derakhshan has completed his MD from Mashhad University of Medical Sciences and currently he is a PhD candidate in Persian medicine at Shahid Beheshti University of Medical Sciences. His research interests are complementary and alternative medicine, allergy and microbiota.

Speaker
Alireza Derakhshan / Shahid Beheshti University of Medical Sciences
Iran

Abstract

 The remedy used in this observational study- Bacillinum
 Bacillinum, a Nosode is a homoeopathic remedy prepared from tubercular sputum by a specialized process of potentisation wherein natural extracts go through ultra-dilution making it non-toxic for consumption.
 INDICATIONS OF BACILLINUM:
1) Chronic Catarrhal conditions of Lungs.
2) Tubercular Meningitis
3) Ringworm, Pityriasis
4) Constant disposition to take cold
5) Enlarged / tender glands of the neck .
6) Eczema of margins of eyelids
7) When best selected remedy fails
8) Intercurrent Remedy
 Renowned Homoeopath Dr. Burnett says: Ringworm of the scalp and pityriasis versicolor on the body are indications of tubercular diathesis and they respond well to this remedy.
Another marked feature recorded by Burnett was ringworms. Burnett was of the opinion that ringworms commonly formed upon those who had inherited phthisis. He thought it was a sign of approaching phthisis, that it was a very common feature or those who have inherited phthisis; and he used the Bacillinum 200th. He used it somewhat as a routine remedy on every child with ringworm.
 We have been prescribing Bacillinum 200 to patients suffering from skin complaints mainly ringworm/pityriasis, eczema, psoriasis and dermatitis for last few years.
 A retrospective observational study was conducted in our clinics and camps (CSR activities) to find out the effectiveness of Bacillinum in treatment of skin diseases.
 The usefulness of Bacillinum 200 in treating skin diseases like ringworm/pityriasis, eczema, psoriasis was re-proved through our studies.

Biography

Sujata Naik M.D.( Homoeopathy) from Mumbai University, India specializes in chronic diseases with Atopic Eczema, Psoriasis and Autoimmune disorders. She lives and practises homoeopathy in Mumbai with patients spanning across the globe. She has been instrumental in promoting homoeopathy at grass root level. Her visits to rural community hospital (where the Bacillinum study was conducted) draw huge crowds. Sujata Naik is a well known writer and excellent orator. Her book promoting health and wellness, ‘The Wellness Shots’ has made it to the bestseller list by Notion press. She has been awarded the 1st prize for her research poster on PCOS at the recently concluded 1st International Conference on Alternative Medicine (AYUSH, Dubai).

Speaker
Sujata Naik / Dr. Sujata Naik’s Homoeopathy Clinic
India

Sessions:

Scientific Sessions

Abstract

In the current age we understand that information is senior to matter and energy. Information encodes matter and energy. The old idea that information needs a matrix (such as a book, brain or computer) is obsolete.
Keith Scott-Mumby will bring forth three separate proofs that information in biological systems and chemical substances (therefore in drugs and remedies) needs no material presence.
The first proof is the phenomenon of cyclotron resonance (CR), in which a variable signal in a fixed magnetic field (in this case the Earth’s geomagnetic field) can convey the signature therapeutic properties of a substance such as lithium (exceptional proof from a US Naval science laboratory, in which no lithium was present, but the pharmacological effect via CR was demonstrated).
The second proof is from homeopathy where substances have a biological effect (very strong evidence for this), despite no actual molecules of the opriginal substance being present. Even homeopaths do not argue that beyond the Avogadro number than can be no physical substance present. But information is still carried (as in the “memory of water”).
The third proof is the demonatrsation by Jacques Benveniste and Nobel-laureate Luc Montagnier that the ecltromagnetic encoding of information signals at homeopathic levels has a demonstrable biological effect. Such electromagnetic “signatures” of substances have been sent across the internet and decoded locally, no physical substance being present.
This marks a new era which Keith has christened “Medicine Beyond” (beyond physics). He has written a book of that title.

Biography

Keith Scott-Mumby obtained his medical qualifications first in the UK (MB ChB), then an international MD. He is a certified doctor of homepathic medicine in the state of Nevada (HMD) and board-certified in chelation from the American College For The Advancement of Medicine. His doctorate thesis (Colombo) was an investigation of the non-material nature of substances. He is author of over 20 books on holistic health, one-time associate professor of psychiatry at the former Capital University of Intergative Medicine and a member of the Nevada Homeopathic licensing Board.

Speaker
Keith Scott-Mumby / Certified doctor of homepathic medicine
United States

Abstract

Every symptom and every cause is an expression of unresolved stress. Due to the current pace of society and the extensive complex societal stress loads worldwide, Traditional Medicine, and her many forms, have been forced to acquiesce the foundational root-based principles, that made Traditional Medicine potent and effective, in favor of the Westernized model of medicine which is system and symptom-focused. This acquiescence has resulted in a new species of medicine called “Naturalized Medicine” - which acts as a bridge between Traditional and Westernized Medicine by shifting the focus from cause to symptom.
Humans want immediate relief from the expression of their symptoms without ever having to consider the impact that their daily complex stressors and/or their lifetime accumulated stress loads are having on their health and well-being.
An amplified focus in the Traditional Medicine community must be on patient educational platforms. “Knowledge is power” is now being amended to “applied knowledge is power.” This implies that, in order to empower individual patients, we must educate them first. And to affect global change, educating patients must be at the forefront of our focus. This will help to break the Westernized medical model of dependency between patients and practitioners which limits the Traditional Medicine community’s ability to establish an interdependent relationship between patient and practitioner.
High-stress states narrow perception and influence choice. Low-stress states widen perception and influence choice. One of the future focuses of Traditional Medicine will have to be on dispersing the lifetime-accumulated stress loads that are amplifying the effects of daily stress. A de-stressed, wellness-focused, educated patient inspires others towards change.

Biography

Christopher Lee Maher is a self-taught innovator in the alternative healing arts. For more than 18 years his sole focus has been on creating systems to relieve and transform the levels of complex stress that interfere with normal biological, energetic, psychological and emotional function. He is a published author, Free for Life. He is also the founder of True Body Intelligence, LLC, a company focused on building educational platforms to help individuals seeking to elevate wellbeing and increase human potential through dismantling inappropriate stress states.

Speaker
Christopher Lee Maher / True Body Intelligence
United States

Abstract

Based on traditional and folk medicines, mushrooms have been developed into anticancer therapeutics. A brief overview is given about the most important medical mushroom species and their specific anti-cancer functions and mechanisms. Taiwanofungus camphoratus (Antrodia cinnamomea) is selected as example of a medical fungus in order to illustrate the general process from ethnomedicine to developing new products for the market based on scientific, analytic, and experimental evidence. The bioactive compounds have indirect effects in cancer treatment by benefiting the immune system as well as having direct cytotoxic effects on cancer cells.
Taiwanofungus camphoratus is a fungus endemic to Taiwan and is one of the most popular known alternative remedies for liver cancer in that country. To date more than 150 liver cancer patients have survived using T. camphoratus. Not only has tumor shrinking been seen to occur but is some instances it disappeared altogether. The ratio between male and female patients has been almost equal, with ages ranging between 20-79 years, and the most effective candidates between the ages of 40-60 years.
The complex mixture of bioactive compounds in natural fruit bodies is a challenge for artificial production in vitro. Particular problems in developing T. camphoratus into therapeutics for the global market are its rarity in nature and its close dependence on an endemic tree in Taiwan. These challenges initiate new solutions which could be transferred to other medical fungi in the future

Biography

I-Shu Lee obtained his PhD in biology from Kassel University in Germany. He joined the staff at the Academia Sinica in Taiwan to investigate the fungus T. camphoratus for its bio-activity and the biochemical mechanism of its anti-cancer properties. Lee is the Standing Supervisor of Antrodia cinnamomea Association of Taiwan Treasure. In 2017, he participated in the writing of textbooks: Functional Foods and Cancer: Functional food in Integrative Oncology: Volume 5. He is also the Director of Research and Development at Taiwan Innovative Technology, a biotechnology company.

Speaker
I-Shu Lee / Antrodia cinamomea Association of Taiwan Treasure
Taiwan

Abstract

Mistletoe extract, including Fraxini, has been used to treat cancer, including hepatocellular carcinoma (HCC), in Europe. However, the mechanism(s) underlying the effect of Fraxini in HCC is(are) inconclusive which hampers its optimal use for the treatment of HCC. We previously reported that mistletoe extracts including Fraxini, Iscador Q and M exerted strong antiproliferative and pro-apoptotic activities in Hep3B cells through targeting c-Myc protein. In current study, we examined the efficacy of Fraxini in HCC bearing animals and further investigated the mechanism by which Fraxini down-regulates c-Myc protein. The c-Myc protein half-life was measured using the cycloheximide chase assay. The antitumor efficacy of the Fraxini was tested in the Hep3B mouse xenograft model and Fraxini was administered subcutaneously. We found that Fraxini dose dependently suppressed the c-Myc protein expression, but did not affect c-Myc mRNA level in Hep3B cells, suggesting Fraxini downregulates c-Myc through post-translation regulation. Fraxini reduced half-life of c-Myc protein from control (40 minutes) to 27 minutes. By inhibition of 26S proteasome activity using MG-132 in Hep3B cells, Fraxini induced downregulation of c-Myc was notably antagonized, suggesting that Fraxini downregulated c-Myc by promoting its proteasome degradation. Fraxini decreased phosphorylation of S62 (stabilizing c-Myc) while slightly increased p-cMycT58 (destabilized c-Myc) in Hep3B cells. When we treated Burkitt’s lymphoma Raji cells, which are known to host T58 mutation on c-Myc and result in c-Myc stabilization, with Fraxini, Fraxini (up to 20 µg/ml) exerted minimum antiproliferative activity, augmenting that Fraxini is acting on c-Myc phosphorylation which resulted downregulation c-Myc and elicited anticancer activity in HCC. Additionally, Fraxini injected (s.c.) to mice carrying Hep3B cell xenograft tumors for 2 weeks significantly reduced the average tumor volume (71.8  22.2 mm3) compared to that in the control treated mice (179.0  36.3 mm3, p < 0.05) and lead to reduction of c-Myc protein. Intriguingly, we also observed that mistletoe lectin, a bioactive component in Fraxini, appears to be most effective in inhibiting the proliferation of c-Myc expressing HCC Hep3B cells compared to that of PLC/RF5 cells with limited expression of c-Myc as well as reduced almost 90% c-Myc protein expression in Hep3B cells. In conclusion, since c-MYC is required for hepatocyte proliferation and liver tumorigenesis, Fraxini and mistletoe lectin through targeting c-Myc may have great therapeutic potential for patients with advanced HCC and warrant further investigation.

Biography

Speaker
Peiying Yang / The University of Texas MD Anderson Cancer Center
United States

Abstract

Asparagus racemosus is belonging to family Asparagaceae and one of the well-known medicinal plants in Ayurveda which has abundant medicinal effects. Physico, chemical and nutritive properties depend on their habitat due to variation of soil, climate, water quality and ecological conditions. Therefore it is important to compare the physico, chemical and nutritive properties of A. racemosus grown in Sri Lanka and India to detect any variations. The objective of present study was to compare the roots of Sri Lankan and Indian grown A. racemosus by physico-chemical, phytochemical and nutritional profiles using WHO guidelines and standard protocols respectively. The analysis of physico-chemical parameters showed that the roots of A. racemosus in Srilankan origin were consisted of 9.7 0.2% total ash, 4.4 0.2% water soluble ash and 0.5 0.0% acid insoluble ash. It was showed that 6.20.1% total ash, 1.90.0% water soluble ash and 1.70.0% acid insoluble ash in Indian origin A. racemosus . Total ash and water soluble ash were significantly higher in Sri Lankan origin A. racemosus that of Indian grown plant. The levels of tested heavy metals (Hg, As, Cd and Pb) were below the WHO acceptable limits and microorganisms including Staphylococcus aureus, Escherichia coli, Coliforms, Salmonella and yeast and moulds were not present in both samples in Srilankan and Indian origin. It was revealed that saponins, tannins, flavonoids, terpenoids, phenols and steroids are present in both the root extracts. However, saponins, tanins, flavonoids and phenols were more prominent in Indian origin A. racemosus.. Twelve prominent spots were appeared in both TLC fingerprint profiles with slight variations in Rf values. Crude protein and crude fiber were significantly higher in Sri Lankan grown A. racemosus that of Indian grown plant. However, carbohydrate content was significantly lower in Sri Lankan origin A. racemosus than that of Indian origin. In conclusion, Srilankan grown A. racemosus has more therapeutic value because the root content significantly high amounts of total ash, water soluble ash, crude protein and crude fiber compared to that of Indian grown A. racemosus.

Biography

Speaker
Y.A.U.D. Karunarathne / Institute of Indigenous Medicine, University of Colombo
Sri Lanka

Abstract

We predicate that during a period of stress, the body’s cells will tend to block anything that it’s exposed to during that period, in order to avoid re-exposure of that same substance in the future. Every substance vibrates with its own unique vibrational frequency, referred to as an electromagnetic fingerprint or “signature”. When exposed to a given substance, the body, will either recognize its signature, or it won’t recognize its signature.
During periods of stress, the cell’s state of vulnerability to discordant frequencies increases. Electro magnetic fields such as mobile phones, microwaves, Wifi, computers, household wiring etc., can enter cells through the cell membrane and alter the cell’s Bioelectrical balance, thus altering the cells recognition of the given substance.
Based on our 17 years experience working with BioEnergetic Intolerance Elimination (BIE), we found it’s able to assist the body in identifying and eliminating stressors. The GSR-120 Bio-resonance unit is utilized to electronically “match” and imprint the electromagnetic signatures back into various points on the body. This allows for recognition and adaptation of stressor(s), in order for the body to heal itself and return to homeostasis. We aren’t treating medical disorders or diseases, we’re simply assisting the body’s cells to correctly identify substances and impart each substance accordingly, in order for the healing process to commence.

Biography

Robert Tomilson, DNM, R.BIE, is co-founder of The Institute of Natural Health Technologies (INHT) and the co-founder of BIE. He began his research in the field magnetic therapy in 1980. Robert's devotion to the field of allergy research, immunology, electromagnetism and biophysics has given him insight into the root causes of disease. Precisely, a disruption in bioenergetic fields resulting in abnormality/pathology. Robert and his partner Silvana Fazzolari DNM, D.Ac., RhA, conduct BioEnergetic Intolerance Elimination (BIE) training programs across North America. Robert is a Doctor of Natural Medicine and an Acupuncturist. His studies include: quantum and biophysics, Acupuncture, Traditional Chinese Medicine, Herbology and Holistic Nutrition. He is a member of the Canadian Association of Natural Nutritional Practitioners.

Speaker
Robert Tomilson / The Institute of Natural Health Technologies Inc
Canada

Abstract

Chronic inflammation is characterized by production of pro inflammatory cytokines: Tumour Necrosis Factor (TNF-α) and Interleukin (IL-1β) by cells involved in inflammatory process particularly monocytes, macrophages and dendritic cells. Inhibition in production of TNF-α and IL-1β by Lipopolysaccharide (LPS) stimulated monocytes/macrophages/dendritic cells represent an important model for screening of anti-inflammatory molecules. Ayurvedic medicines, Guggulu thiktha gritham, Varanadi Kashayam and Yogaraj guggulu vatika, which are used in ayurvedic form of medicine for treatment of various types of pathologic condition associated with chronic inflammation were evaluated for their ability to inhibit production of TNF-α and IL-1β by LPS stimulated monocytes/macrophages. THP-1 monocytic cell lines and THP-1 derived macrophages were used for the study. Cells were pre-incubated with different solvent fractions, prepared by fractionation of the ayurvedic medicine with different solvents, prior to treatment with LPS. Following incubation, levels of TNF-α and IL-1β secreted by cells into the media were analysed by ELISA. TNF-α and IL-1β levels were quantified and compared with positive control Rolipram and Dexamethasone. Bioactive molecules present in the most active fraction were determined by UPLC QToF/MS. Identified molecules were then docked with TNF-α convertase enzyme (TACE) and Capase-1 which are involved in secretion of soluble TNF-α from membrane bound TNF-α and maturation of IL-1β respectively.

Biography

Prakash Kumar B completed his doctoral degree from Sree Chitra Tirunal Institute For Medical Sciences and Technology, India and is presently working as Professor in Biochemistry at School of Biosciences, Mahatma Gandhi University, Kerala, India. He is also the Director of the College Development Council and is a member of the University Research Committee. He has published 21 papers in Journals of repute.

Speaker
Prakash Kumar B / School of Biosciences, Mahatma Gandhi University
India

Abstract

Eight rare class of dimeric napthoquiones namely; di-naphthodiospyrol A (1), di-naphthodiospyrol B (2), di-naphthodiospyrol C (3), di-naphthodiospyrol D (4), di-naphthodiospyrol E (5), di-naphthodiospyrol F (6), di-naphthodiospyrol G (7) and di-naphthodiospyrol H (8) were isolated from the chloroform fraction of Diospyros lotus. Their structures were elucidated by spectroscopic analysis including 1D and 2D NMR experiments such as HSQC, HMBS, NOESY and J-resolved. Compounds (1-8) were also assessed for their effects on the reversion of multidrug resistant (MDR) mediated by P-glycoprotein using rhodamine- 123 exclusion screening test on human MDR1 gene transfected mouse gene transfected L5178 and L5178Y mouse T-cell lymphoma. The compounds (1-8) were also assessed for antiproliferative effect on L5178Y mouse T-lymphoma cell line. Di-naphthodiospyrol A (1) Di-naphthodiospyrol B (2) exhibited promising antiproliferative and MDR reversing effect in a dose dependent manner against mouse T-lymphoma cell line. All isolated compounds (1-8) were also screening for urease inhibition potential which showed good activity.

Biography

Abdur Rauf has completed his PhD from Insitute of Chemical Sciences, University of Peshawar, KPK, Pakistan. He is the Assistant professor of Natural Products Chemistry, in the Department. He has published more than 200 papers in reputed journals having more then 215.31 impact factors and has been serving as an editorial board member of sevreal repute journal.

Speaker
Abdur Rauf / University of Swabi
Pakistan

Abstract

Many classical drugs are claimed to have blood sugar lowering properties that make them valuable for people with or at high risk of type 2 diabetes. Vijaysar (Pterocarpus marsupium) and Gaumutra (Indian cow urine) both have been shown antidiabetic property since primordial time and both shows synergistic effect in combination for hypoglycaemic activity. The study was undertaken to investigate the hypoglycaemic and anti-diabetic effects of the combination of Vijaysar and Gaumutra which is a classical preparation mentioned in Ayurveda named as Pramehari ark. Rats with Type 2 diabetes which is induced by streptozotocin (STZ, 35mg/kg) given a high-fat diet for one month and compared with normal rats. Diabetic rats showed raised level of body weight, triglyceride (TG), total cholesterol, HDL, LDL, and D-glucose concentration and other serum, cardiac and hypertrophic parameters in comparison of normal rats. After treatment of different doses of drug the level of parameters like TG, total cholesterol, HDL, LDL, and D-glucose concentration found to be decreased in standard as well as in treatment groups. In addition treatment groups also found to be decreased in the level of serum markers, cardiac markers, and hypertrophic parameters. The findings demonstrated that Pramehari ark prevented the pathological progression of type 2 diabetes in rats.

Biography

Speaker
Riddhi Hiteshbhai Shukla / Department of Pharmaceutical Sciences, Saurashtra University
India

Abstract

Achyrathus aspera, Saturaja punctata, Rumex abysinicus, Chenopodium murale and Aloe pulcherrima are among medicinal plants traditionally employed to treat urolithiasis and various ailments in Ethiopia. The present study was aimed to assess acute and sub-acute toxicity of 70% ethanol plant extracts in rats. Albino Wistar female rats were treated with extracts using a fixed oral dose of 2000 mg/Kg per body weight to determine acute and sub-acute toxicity. The rats were sacrificed at day 14th (acute) and day 21th (sub-acute) treatment for hematological and histopathology studies. The results were computed statistically using one-way analysis of variance followed by Tukey’s multiple comparison test. In both toxicity studies, there was no mortality and significant variations in body weight. In acute toxicity test, C. murale extract reduced the mean corpuscular haemoglobin concentrations (MCHC) compared with control groups (P < 0.05). Similarly, hematocrit (HCT) level significantly declined among groups that received test extracts of C. murale and the combination (P<0.05) in sub-acute study. All plant extracts significantly reduced the platelet distribution width (PDW); mean platelet volume (MPV); and platelet larger cell ratio (P-LCR) in treated groups compared with control group (P<0.05).The results of liver histopathological studies demonstrated that C. murale was profoundly toxic at given dose revealing focal periportal hepatitis. But, the rest of the extracts showed normal architecture. The extracts of C. murale and the combination (Ra+Sp+Aa) showed a patch of acute tubular injuries for kidney histopathology. In comparisons with control group, rats treated with A. aspera, S. punctata and R. abysinicus revealed mild injury. C. murale extracts revealed toxicity at the given dose for both tests. Liver and kidney histopathological evaluations showed that this extract provoked cellular alterations.This was supported by declined hematological values of HCT, PDW and MPV. Although there is a problem of extrapolating animal study data to humans, the rest plant extracts seems relatively safe. Further chronic toxicity studies and phytochemical characterizations of active compounds is required to gain a better understanding of the safety profile of the extracts.

Biography

Tilahun Alelign has completed his Msc in Biomedical Sciences since 2010 from Addis Ababa University, Ethiopia. He has about 6 publications , and presented some of this papers in scientific conferences of Ethiopia. His research interests include searching natural products to cure kidney stone, kidney failure, related kidney disorders, and various ailments. Currently, he is attending PhD studies at Addis Ababa University, Ethiopia. His research project focuses on traditional medicine to come up with alternative treatment options for kidney calculi.

Speaker
Tilahun Alelign Wassie / Addis Ababa University
Ethiopia

Abstract

Multiple sclerosis is one of the most salient degenerative disorders of CNS with dysregulated immune process that resulted in axonal damage and demyelination. Gender differences in epidemiological, clinical, and pathological features of multiple sclerosis (MS) have been observed for many years establishing a foundation for more recent progress in our understanding of the role of hormones on the disease. We aimed in the present investigation to find the etiology of MS on the basis of their 5 years hormonal abnormalities and sexual histories in women. The serum levels of testosterone were assessed in women who were struggling with multiple sclerosis (MS). Also, the levels of omega-3, vitamin D, and the irregular menstruation in women 5 years before the onset of MS symptoms were surveyed. Although the levels of omega-3 and vitamin D in MS women patients were not significantly less than the healthy ones, they were significantly less in the whole population of MS patients (both genders). Moreover the MS patients experienced more irregular menstruation some years before the onset of MS with the lower serum levels of testosterone. Based on the presented findings, it might be said that the vitamin D intake has significant protective role in women and men MS patients unlike the omega-3 that had significant protective role just in men. The low level of testosterone and vitamin D consumption increase the neural damage and pro-inflammatory pathways in MS patients, and the difference among the investigations is related to the long-standing history of MS that influences severity of damage to the neural cells and biomolecules and complicate its recovery. In this talk several therapeutic approaches will be proposed using exogenous hormones and herbals in both genders according to our recent studies. Nevertheless, the study of gender and hormones is rich with potential for new insights into MS pathogenesis, and thus, new approaches to treatment in the future which could be provided by herbal medicine.

Biography

Sepideh Arbabi Bidgoli, Pharm.D., Ph.D is Prof. of Toxicology, President of Iranian Environmental Mutagen Society (IrEMS), director of Pharmaceutical Sciences Research Center at Islamic Azad University, Pharmaceutical Sciences Branch, Director in charge of the Journal of Water and Environmental Nanotechnology ,Editor in Chief of Journal of Pharmaceutical and Health Sciences and official member of Asian Council of Science Editors. She has served as the Secretary General of Iran NanoHealth Committee with a demonstrated history of working and consulting in the pharmaceutical industries, regulation of NanoHealth products, research in the field of cancer and toxicology sciences and education of Toxicology, Pharmacology, Ethics, Research Methods and Scientific writing as the official license of Tim Albert Method in Iran . With more than 100 papers and more than 50 lectures as invited speaker in international prestigious conferences, more than 15 international and national awards, 0 pharmaceutical circular guidelines and advising more than 120 pharm D., MSc and PhD students, she is well skilled in Toxicology and Pharmacology, Cancer Biomarkers, Nanotoxicology , reproductive toxicology and herbal toxicology . She is now focused in Genetic Toxicology of susceptible populations in Iran using new test methods by close national and international collaborations . Using art therapy, music therapy and alternative medicine are her future strategies for conducting the rest of her professional activities.

Speaker
Sepideh Arbabi Bidgoli / President of Iranian Environmental Mutagen Society (IrEMS)
Iran

Abstract

Inflammation leading to cells necrosis is the response of lungs tissues to Mycobaterium tuberculosis invasion and immune reactions during tuberculosis infection. The success in tuberculosis resistant treatment showed that one of the great challenges is to find new antibiotics which target both multiresistant and extensive drug resistant strains and even more aid to repair tissues damages. Plant essential oils are mixtures of natural components with multipotential activities can acting by inhibiting bacterial invasion and metabolism disorders related to illnesses such as inflammation. The designed study assesses in vitro anti-inflammatory and antimycobacterial capacity of Echinops giganteus Roots essential oils. The essential oil is obtained by hydrodistillation using Clevenger apparatus and chemical composition of essential oils was determined simultaneously by Gas Chromatography (GC) and Gas Chromatography coupled to Mass Spectrometry (GC/MS). Anti-inflammatory activity of Echinops giganteus roots essential oil was performed by using bovine serum albumin denaturation and inhibition of anti-proteinase action methods. The anti-mycobacterial activity of these essential oils was evaluated against three isolates of Mycobacterium tuberculosis (one sensitive to all drugs, one multiresistant and one extensively drug resistant) using the microdilution method. The chemical analysis of the essential oils showed the presence of silphiperfol-6-ene (27,40%), silphiperfolan-6--ol (11,30%), persilphiperfol-7-ène (7,40%) 7-épi-silphiperfol-5-ene (6,02%) et caryophyllene (6,96%). The essential oils exhibited anti-inflammatory activity by proteinase inhibition action and BSA denaturation with respective IC50 of 2.99 μg/mL and 3.43 μg/mL. Echinops giganteus roots essential oil exhibited good antimycobacterial activity with minimal inhibitory concentration of 52.08 μg/mL against sensitive and multiresistant isolate and 39.06 μg/mL extensively drug resistant isolate. the results showed good mycobacterial inhibition growth and potent inhibitory activity against the adverse effects of the inflammation such as tissue damage and protein denaturation during Mycobacterium tuberculosis infection.

Biography

MONI NDEDI Esther Del Florence completed her Master degree from Biochemistry department of University of Yaounde I, Cameroon. She is now A PhD student in microbiology department in the same University and work as Temporarly assistant. She has published 04 papers.

Speaker
Moni Ndedi Esther Del Florence / University of Yaounde I
Cameroon

Abstract

Traditional medicinal plants have been used as an alternative medicine in many parts of the world, including Ethiopia. Studies also reveal anti-Quorum Sensing potential of selected medicinal plants. To our knowledge, however, there is no report on the anti-Quorum Sensing activities of traditional medicinal plants from Ethiopia. As many of the opportunistic pathogenic bacteria depend on Quorum Sensing (QS) systems to coordinate their virulence expression, interference with microbial cell-cell communication (QS) could be a novel approach to control bacterial infections. The aim of this study was, therefore, to evaluate extracts of selected medicinal plants from Ethiopia for their antimicrobial activities and interference with cell-cell signaling in bacteria. Antimicrobial activities of the crude extracts were evaluated following standard agar diffusion techniques. The minimum inhibitory concentrations (MIC) of potent extracts were determined using 96 well micro-plates and an ELISA plate reader for optical density measurement. Interference in Quorum Sensing of extracts was determined using E. coli based reporter strain. Petroleum ether extract (PE) of seed of Nigella sativa exhibited the highest activity against both the laboratory isolated Bacillus cereus [inhibition zone diameter (IZ), 44 mm] and B. cereus ATCC 10987 (IZ, 40 mm). Similarly, oil from mature ripe fruit husk of Aframomum corrorima and mature unripe fruit of A. corrorima revealed promising activities against Candida albican (IZ 35 mm) and Staphylococcus aureus (IZ 25 mm), respectively. PE extracts of seed of N. sativa and oil from husk of A. corrorima exhibited better antimicrobial activity than the control antibiotic (Gentamycin sulfate). Of the total eighteen extracts, assessed in this study, two of the extracts interfered with cell-cell communication most likely through interaction with the signaling molecules (N-acylated homoserine lactone), specifically the N-(ß-ketocaproyl)-L-homoserine lactone (3-oxo-C6-HSL) used in the growth medium along the reporter strain. Traditional medicinal plants from Ethiopia could continue serving as potential source of alternative medicine for the local community and priority area of research for the scientific community in searching for alternative drug to cope up with the current challenges due to emergence of antibiotic resistant pathogens. Furthermore, the quorum quenching activities observed in two of the plant extracts calls for more comprehensive evaluation of medicinal plants for control of many of bacterial processes and phenotypic behaviors such as pathogenicity, swarming, and biofilm formation.

Biography

Speaker
Ketema Bacha / Jimma University
Ethiopia

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